Abstract:Aim:The aim of the present work was to predict the bioavailability (BA) of poorly soluble drug. In vitro dissolution of selected BCS Class II drug was conducted in different dissolution media to identify the discriminatory behaviors of the dissolution media. Further, the development of physiology-based pharmacokinetic modeling performed using GastroPlus ® for BA predictions of formulation showing enhanced dissolution. Study Design: Using GastroPlus® software (Simulations Plus, Lancaster, CA), a physiology-base… Show more
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