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Abstract

Background: Two groups patients of TYPE 2 DM were treated with Repaglinide and voglibose in postprandial hyperglycemia in newly diagnosed patients of different age groups and in both sexes. Methods: 250 patients were taken in to study, and they are divided in to 2 groups, group A and B. A group was treated with Repaglinide 1mg and B group was treated with voglibose .3mg. Blood sugar was analyzed, both fasting and postprandial by auto-analyzer by oxidase methods and hbA1c was analyzed by capillary electrophoresis method. Results: hbA1c analyzed in both A and B groups before treatment, and after 3 month of the treatment. And mean values of both groups treated with different drugs (Repaglinide and voglibose) had significant p value (P<0.01). In FBS before treatment and after 3 month of the treatment in both groups were highly significant mean value (P<0.01).In comparative Study of PPBS before treatment and after 3 months in both groups were highly significant statistically (P<0.01). BMI was raised in group A (Repaglinde) as compared to group B (voglibose) and least adverse reactions were observed in patients of group A (Repaglinide) Conclusion: Although both drugs were equally effective in controlling post prandial hyperglycemia but Repaglinide proved to be better because of its least adverse reactions.