La 8.ª edición de la clasificación AJCC-TNM: nuevas aportaciones a la estadificación del cáncer de la unión esofagogástrica

Sos, Javier Escrig; Quiles, Luis Gómez; Maiocchi, Karina

doi:10.1016/j.ciresp.2019.03.006

Cited by 9 publications

(1 citation statement)

References 10 publications

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“…The objective of this study is to evaluate diagnostic accuracy in the clinical staging of localized esophageal cancer. For this purpose, clinical staging was compared with the anatomopathological staging (8 th edition of the TNM classification) 11 .…”

Section: Introductionmentioning

confidence: 99%

Staging accuracy in resecable esophageal cancer. Observational retrospective study

Andrés-Imaz,

Martí-Gelonch,

Eizaguirre-Letamendia

et al. 2024

CIRUE

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Objective: To assess the accuracy of the diagnostic tests for a correct clinical tumor staging in localized esophageal cancer (EC).Method: Retrospective observational study of patients who underwent esophagectomy for cancer in a referral hospital between January 2003 and September 2019. Those patients who received neoadjuvant treatment were excluded in order to avoid bias from downstaging effects. The preoperative stage was compared with the pathological stage of the surgical specimen. Computed tomography (CT), endoscopic ultrasound (EUS) and positron emission tomography (PET) were evaluated. The pT stage was correlated with the tumor length described in the esophagram (EG). Results: Among the 63 patients included, the clinical staging was correct in 16 (global accuracy 25.4%), it was overstaged in 21 (33.2%) and understaged in 26 (41.3%). For cT staging, the accuracy of EUS was higher than that of CT (46.6% and 34.9%, respectively), specially for early stages. EG tumor length correlated with pT stage (p < 0.05). For cN staging, PET had the highest sensitivity (50.0%) and negative predictive value (75.0%). Conclusions: Despite the multiple diagnostic tools used, the global accuracy of clinical staging in localized EC is still a challenge. The lack of a test that stands out significantly from the others reinforces the need to use them in a complementary way.

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Section: Introductionmentioning

confidence: 99%

Staging accuracy in resecable esophageal cancer. Observational retrospective study

Andrés-Imaz,

Martí-Gelonch,

Eizaguirre-Letamendia

et al. 2024

CIRUE

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Increased STX3 transcript and protein levels were associated with poor prognosis in two independent cohorts of esophageal squamous cell carcinoma patients

Shinozuka,

Kanda,

Sato

et al. 2023

Cancer Medicine

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BackgroundSome conventional prognostic biomarkers for esophageal squamous cell carcinoma (ESCC) have the disadvantage that they have only been investigated at the level of either mRNA or protein levels or only in individual cohorts. Associations between Syntaxin 3 (STX3) expression and malignancy have been reported in several tumor types but not in ESCC. Here, we investigated the levels of both STX3 mRNA and protein, and its prognostic potential in two independent cohorts of patients with ESCC.MethodsSTX3 mRNA levels were examined in surgical specimens by quantitative PCR in a cohort that included 176 ESCC patients. STX3 protein levels were investigated in surgically resected ESCC tissues by immunohistochemistry using tissue microarrays in a different cohort of 177 ESCC patients. Correlations were analyzed between the expression of STX3 mRNA and protein with clinicopathological factors and long‐term prognosis.ResultsQuantitative PCR indicated a significant association between high level of STX3 mRNA expression and lymph node involvement, pathological stage, and poor overall survival. The multivariate analysis demonstrated that high STX3 mRNA expression was independently associated with poor overall survival outcomes. Immunohistochemistry revealed that STX3 protein expression in ESCC tissues and high STX3 protein expression were also significantly correlated with unfavorable overall survival.ConclusionsOverexpression of STX3 mRNA and protein may serve as potential prognostic biomarkers for ESCC patients.

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En bloc mesoesophageal esophagectomy through thoracoscopy combined with laparoscopy based on the mesoesophageal theory

et al. 2022

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La 8.ª edición de la clasificación AJCC-TNM: nuevas aportaciones a la estadificación del cáncer de la unión esofagogástrica

Cited by 9 publications

References 10 publications

Staging accuracy in resecable esophageal cancer. Observational retrospective study

Staging accuracy in resecable esophageal cancer. Observational retrospective study

Increased STX3 transcript and protein levels were associated with poor prognosis in two independent cohorts of esophageal squamous cell carcinoma patients

En bloc mesoesophageal esophagectomy through thoracoscopy combined with laparoscopy based on the mesoesophageal theory

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