La balance bénéfices–risques du traitement hormonal de la ménopause : cancers et mortalité. RPC Les femmes ménopausées du CNGOF et du GEMVi

Poudou, Caroline; Baffet, Hortense; Nadeau, C.; Rolland, A.-L.; Catteau-Jonard, Sophie; Robin, Geoffroy

doi:10.1016/j.gofs.2021.03.031

Cited by 2 publications

(1 citation statement)

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“…Thus, estrogen replacement therapies, which improve menopause symptoms, could have the ability to induce telomerase mRNA expression in menopausal women [40 ▪▪ ], therefore, increasing telomere length [41]. However, these therapies are controversial because of their side effects, particularly concerning cancer risk [42].…”

Section: Ovarian Agingmentioning

confidence: 99%

Telomeres, aging and reproduction

Córdova-Oriz

Chico-Sordo

Varela

2022

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewWomen's fertility decay starts at the mid 30 s. However, the current delay of childbearing leads to ovarian aging and the need of assisted reproduction technologies (ART). Telomere biology is one of the main pathways involved in organismal aging. Thus, this review will focus on the knowledge acquired during the last 2 years about the telomere pathway and its influence on female fertility and the consequences for the newborn.Recent findingsNew research on telomere biology reaffirms the relationship of telomere attrition and female infertility. Shorter maternal telomeres, which could be aggravated by external factors, underly premature ovarian aging and other complications including preeclampsia, preterm birth and idiopathic pregnancy loss. Finally, the telomere length of the fetus or the newborn is also affected by external factors, such as stress and nutrition.SummaryRecent evidence shows that telomeres are implicated in most processes related to female fertility, embryo development and the newborn's health. Thus, telomere length and telomerase activity may be good biomarkers for early detection of ovarian and pregnancy failures, opening the possibility to use telomere therapies to try to solve the infertility situation.

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Section: Ovarian Agingmentioning

confidence: 99%