La Biosynthègse Induite Des Enzymes (Adaptation Enzymatique)

Monod, Jacques; Cohn, Melvin

doi:10.1002/9780470122587.ch3

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2018

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Cited by 27 publications

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“…The lactose repressor (LacI) regulates the expression of a set of genes involved in lactose metabolism in the bacterium Escherichia coli . LacI was one of the first gene-regulatory proteins discovered 1 and is well studied. 2 The structure has been determined to have four main regions: the tetramerization region (TR), regulatory domain (RD), hinge-helix linker region (HH), and DNA-binding domain (DBD) 3 , shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Price of disorder in the lac repressor hinge helix

Seckfort

Pettitt

2018

Biopolymers

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The Lac system of genes has been pivotal in understanding gene regulation. When the lac repressor protein binds to the correct DNA sequence, the hinge region of the protein goes through a disorder to order transition. The structure of this region of the protein is well understood when it is in this bound conformation, but less so when it is not. Structural studies show that this region is flexible. Our simulations show this region is extremely flexible in solution; however, a high concentration of salt can help kinetically trap the hinge helix. Thermodynamically, disorder is more favorable without the DNA present.

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Section: Introductionmentioning

confidence: 99%