La chémérine

Reverchon, Maxime; Ramé, Christelle; Dupont, Joëlle

doi:10.1051/medsci/20153105010

Cited by 9 publications

(3 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemerin is involved in the regulation of blood pressure, inflammation, immune responses, adipocytes differentiation, and carbohydrate metabolism and plays a key role in metabolic diseases, such as obesity and diabetes [ 202 ]. GPR1 knockout mice fed with a high-fat diet developed serious glucose intolerance and a test of pyruvic acid tolerance suppressed glucose-stimulated insulin levels that consequently increased glycaemia [ 203 ].…”

Section: Chemerinmentioning

confidence: 99%

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Mellouk

Ramé

Barbe

et al. 2018

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species.

show abstract

Section: Chemerinmentioning

confidence: 99%

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Mellouk

Ramé

Barbe

et al. 2018

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The region with the largest proportion of variance contains the RARRES2. Previous studies documented that RARRES2 regulates lipid metabolism and adipogenesis and mediates hormone secretion through gonadal functions in mice and humans (Goralski et al, 2007;Reverchon et al, 2015). Previous literature supported that the SNT occurrence may result from the abnormal secretion of hormone (Brka et al, 2002;Hotchkiss et al, 2007).…”

Section: Discussionmentioning

confidence: 98%

Genetic parameters and weighted single-step genome-wide association study for supernumerary teats in Holstein cattle

Wen

Luo

Yang

et al. 2021

Journal of Dairy Science

View full text Add to dashboard Cite

Supernumerary teats (SNT) are a common epidermal abnormality of udders in mammals. The SNT negatively affect machine milking ability, udder health, and animal welfare and sometimes act as reservoirs for undesirable bacteria, resulting in economic losses on calves and lactating cows due to the cost of SNT removal surgery, early culling, and low milk yield. This study aimed to analyze the incidence and genetic parameter of SNT and detect SNT-related genes in Chinese Holstein cattle. In this study, the incidence of SNT was recorded in 4,670 Chinese Holstein cattle (born between 2008 and 2017) from 2 farms, including 734 genotyped cows with 114,485 SNPs. The SNT had a total frequency of 9.8% and estimated heritability of 0.22 (SE = 0.07), which were obtained using a threshold model in the studied Chinese Holstein population. Furthermore, we calculated approximate genetic correlations between SNT and the following indicator traits: 12 milk production, 28 body conformation, 5 fertility and reproduction, 5 health, and 9 longevity. Generally, the estimated correlations, such as 305-d milk yield for third parity (−0.55; SE = 0.02) and age at first calving in heifer (0.19; SE = 0.03), were low to moderate. A single-step GWAS was implemented, and 10 genes associated with SNT located in BTA4 were identified. The region (112.70-112.90 Mb) on BTA4 showed the highest genetic variance for SNT. The quantitative trait loci on BTA4 was mapped into the RARRES2 gene, which was previously shown to affect adipogenesis and hormone secretion. The WIF1 gene, which was located in BTA5, was also considered as a candidate gene for SNT. Overall, these findings provide useful information for breeders who are interested in reducing SNT.

show abstract

“…Lack of RARRES2 or CMLKR1 expression in vitro abrogates adipogenesis [1]. Recent studies showed that RARRES2 and CMKLR1 are expressed in the reproductive tract and could regulate gonadal functions [12]. Recombinant RARRES2 was found to suppress both basal estradiol secretion in granulosa cells (GC) from normal rats and FSH-induced progesterone and estradiol secretion in cultured preantral follicles and GC in vitro, suggesting the possible involvement of RARRES2 in the regulation of ovarian follicle growth and function [13, 14].…”

Section: Introductionmentioning

confidence: 99%

Possible involvement of the RARRES2/CMKLR1-system in metabolic and reproductive parameters in Holstein dairy cows

Mellouk

Ramé

Diot

et al. 2019

Reprod Biol Endocrinol

Self Cite

View full text Add to dashboard Cite

Background In dairy cows, the energy cost of milk yield results in a negative energy balance (EB) and body fat mobilization that impairs reproductive efficiency. Emerging evidence suggests that the novel adipokines, Retinoic acid receptor responder protein 2 (RARRES2), and its main receptor, Chemokine-like receptor 1 (CMKLR1) are involved in the regulation of metabolic and ovarian functions. So, we investigated in a first experiment the plasma RARRES2, and RARRES2 and CMKLR1 mRNA expression levels in subcutaneous adipose tissue (SAT) and granulosa cells (GC) at different times of body fat mobilization in dairy cows (4, 8, 20 and 44 weeks postpartum, wk. pp. for SAT and 8, 20 and 44 wk. pp. for GC). Then, in a second experiment we examined the effect of high (HE) and low energy (LE) diets on the RARRES2 system and its links with metabolic and reproductive parameters. Methods The first experiment included 9 animals fed with HE diet from 4 to 44 wk. pp. and the second one included animals fed either a HE diet ( n = 8) or a LE diet ( n = 8) from − 4 to 16 wk. peripartum. In both experiments, various metabolic and reproductive parameters were determined and associated with plasma RARRES2 as measured by bovine ELISA. RARRES2 and CMKLR1 mRNA expression levels were analyzed by RT-qPCR in SAT after biopsy and GC after aspiration of follicles. Results Plasma RARRES2 levels were higher at 4 wk. pp. as compared to 20 and 44 wk. pp. and they were positively correlated with body fat mobilization and milk yield. RARRES2 and CMKLR1 mRNA expression levels increased from 4 to 8 wk. pp. (fat mobilization, EB < 0) and remained unchanged at 20 and 44 wk. pp. (fat reconstitution, EB > 0) as compared to 4 wk. pp. in SAT. RARRES2 and CMKLR1 mRNA levels decreased from 8 to 44 wk. pp. in GC from small follicles. In the second experiment, plasma RARRES2 increased from − 4 to 8 wk. peripartum similarly in both LE and HE cows. In addition, the area under of plasma RARRES2 curve was highly negatively associated with the number of small follicles obtained in HE animals during the cycle before the first artificial insemination. In SAT of HE cows, RARRES2 mRNA expression decreased at 1 wk. pp. compared to − 4 and 16 wk. peripartum whereas opposite expression patterns were obtained for CMKLR1. Similar results were observed for CMKLR1 mRNA expression in LE cows while there was no variation in RARRES2 mRNA expression. Moreover, RARRES2 mRNA was higher expressed in LE than in HE cows at 1 wk. pp. Conclusions The lactation-induced fat and energy mobilization influenced plasma RARRES2 profile and mRNA expression pattern of RARRES2 and CMKLR1 similarly in both SAT and GC. In addition, the energy content of the diet did not affect plasma RARRES2 but it altered RARRES2 mRNA expression in SAT and the area under the curve of plasma RARRES2 that was negatively associated to the number of small follicl...

show abstract

La chémérine

Cited by 9 publications

References 53 publications

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Genetic parameters and weighted single-step genome-wide association study for supernumerary teats in Holstein cattle

Possible involvement of the RARRES2/CMKLR1-system in metabolic and reproductive parameters in Holstein dairy cows

Contact Info

Product

Resources

About