La Crosse Encephalitis: An Adult Case Series

Teleron, Amy Lynn A.; Rose, Brandon; Williams, David M.; Kemper, Suzanne; McJunkin, James E.

doi:10.1016/j.amjmed.2016.03.021

Cited by 23 publications

(21 citation statements)

References 3 publications

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“…Interspecific interactions among Aedes mosquitoes in southern Appalachia are of medical importance because they may influence the transmission of La Crosse virus (LACV) to humans (Bevins 2008). Although LACV‐infected adults are often asymptomatic (Wurtz and Paleologos 2000, Teleron et al 2016), LACV infection can lead to paralysis, seizures, and death in pediatric patients (Balkhy and Schreiber 2000, Hardin et al 2003, Lambert et al 2015). Few La Crosse encephalitis cases were diagnosed in southern Appalachia prior to the discovery of the invasive Ae.…”

Section: Introductionmentioning

confidence: 99%

Aedes albopictus oviposits with other Aedes species in artificial oviposition cups: a case study in Knox County, Tennessee, U.S.A.

Dixson

Jackson

Rowe

et al. 2020

Journal of Vector Ecology

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Interspecific associations between two mosquito species can lead to effects such as competition, species displacement, and species stability. To better understand Aedes albopictus (Skuse) and other Aedes species, we monitored eggs in artificial oviposition cups (ovitraps) within Knox County, TN, U.S.A., during the 2016 and 2017 mosquito seasons. In 2016, one black and one white ovitrap were placed at 18 sites for 21 weeks, while in 2017 black and white ovitraps baited with grass‐infused or deionized water were placed at 11 sites for nine weeks. Eggs were identified to species and resulting counts were used to determine the degree of interspecific association using Cole's coefficients (C7) and the degree of heterogeneity across space and time using generalized linear mixed models (GLMM). Here, Aedes mosquitoes are generally ovipositing in black cups with grass‐infused water, and Ae. albopictus eggs co‐occurred with other Aedes species more often than would be expected. Finding a positive significant interspecific association between Ae. albopictus and other Aedes eggs suggests that methods used to control Ae. albopictus may also control other Aedes mosquitoes. Finding that Ae. albopictus co‐occurs with other Aedes mosquitoes warrants additional research to evaluate outcomes associated with co‐occurrence within the study area.

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Section: Introductionmentioning

confidence: 99%

Aedes albopictus oviposits with other Aedes species in artificial oviposition cups: a case study in Knox County, Tennessee, U.S.A.

Dixson

Jackson

Rowe

et al. 2020

Journal of Vector Ecology

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“…In a case series of 10 adult patients, LACV encephalitis was associated with altered mental status, prolonged ICU stay, and a high rate of disability. 119 LACV encephalitis may mimic HSV encephalitis, as both may present with pleocytosis in the CSF, hemorrhagic features, and epileptiform activity in the temporal lobe. 118,120 Mortality occurs in less than 1% of cases.…”

Section: Family Phenuiviridae (Group V)mentioning

confidence: 99%

Emerging Viral Infections and Their Impact on the Global Burden of Neurological Disease

et al. 2018

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Emerging viral infections of the nervous system represent a major global public health concern in the 21st century. They are caused primarily by RNA viruses and are mostly associated with acute or subacute encephalitis. The spectrum of associated central or peripheral nervous system disorders is broad, and results either from a direct viral effect or due to the host immune responses against the infection. Emerging viral infections impose substantial neurological morbidity and mortality, particularly in low- and middle-income regions. In the past five decades, vector-borne viruses primarily transmitted by arthropods, or arboviruses, have been responsible for epidemics with a high burden of neurological disease, like the 2015-2016 Zika virus epidemic in the Americas. Viruses that have become neurovirulent for humans after geographical expansion include West Nile, Dengue, and Zika viruses. Factors such as animal migration, disruption of ecological niches, and cross-species contact have caused old viruses to reappear and cause neurological disease, as is the case of Ebola virus. In addition to these biological challenges, current preventive strategies, vaccination, and diagnostic and therapeutic approaches remain limited. We review the clinical-virological features and global impact of the most relevant emerging viral infections of the nervous system as they are projected over the 21st century.

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“…Highly seasonal, the majority of LACE cases have an onset of illness during the months of July through September [3]. Although most LACE cases are reported in children younger than 15 years of age, adult cases are also occasionally recognized [8].…”

Section: La Crosse Encephalitismentioning

confidence: 99%

La Crosse Encephalitis: A Persistent Arboviral Threat in North Carolina

Byrd¹

2016

North Carolina Medical Journal

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Mosquito-borne diseases remain a significant cause of economic, social, and health burdens in North Carolina. Although recently overshadowed by emerging threats such as chikungunya virus and Zika virus, La Crosse virus and other endemic arboviruses remain persistent environmental health hazards. Indeed, La Crosse virus, West Nile virus, and Eastern equine encephalitis virus accounted for more than 98% of the reported human arboviral diseases acquired in North Carolina in the past decade. Arbovirus infection is increasingly prevalent in Western North Carolina, with La Crosse encephalitis being endemic in this area. While infections are often asymptomatic and seldom fatal, the long-term neurologic sequelae of La Crosse encephalitis represent a significant burden.

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La Crosse Encephalitis: An Adult Case Series

Cited by 23 publications

References 3 publications

Aedes albopictus oviposits with other Aedes species in artificial oviposition cups: a case study in Knox County, Tennessee, U.S.A.

Aedes albopictus oviposits with other Aedes species in artificial oviposition cups: a case study in Knox County, Tennessee, U.S.A.

Emerging Viral Infections and Their Impact on the Global Burden of Neurological Disease

La Crosse Encephalitis: A Persistent Arboviral Threat in North Carolina

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