“…The American Heart Association (AHA) has recently introduced the concept of Cardiovascular-Renal-Metabolic Syndrome (CRMS), providing a significant opportunity to improve multidisciplinary approaches and early intervention in the risk stratification, prevention, and treatment of this complex syndrome. This framework recognizes the interplay of cardiovascular, renal, and metabolic risk factors, exacerbated by cardiovascular diseases (including HF, atrial fibrillation, coronary artery disease, stroke, and peripheral artery disease), CKD, and type 2 diabetes, with excessive or dysfunctional adiposity as the underlying issue ( 4 , 5 ). Three publications within this Research Topic establish a solid foundation for a conceptual and actionable framework by examining the interrelationship between obesity and glomerular hyperfiltration and hypertrophy and exploring the causal relationships between kidney function and cardiovascular diseases, as well as between metabolic syndrome and kidney disease.…”