La dysplasie fibreuse de l’extrémité proximale du fémur chez l’enfant et l’adolescent

Durand, Sébastien; Hamcha, H.; Pannier, Stéphanie; Padovani, J; Finidori, G; Glorion, C.

doi:10.1016/s0035-1040(07)90199-3

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…Therefore the operation was canceled, although, in the literature, authors showed that prophylactic osteosynthesis in fibrous dysplasia was necessary. This case approved that in severe cases, biphosphonate was useful [33]. Some authors were also afraid of the PF deformity and advised operating to avoid arthrosis [34,35].…”

Section: Discussionmentioning

confidence: 76%

Case series study: the diagnosis and treatment of fifty tumors and pseudotumors at the proximal femur

Van¹,

Cao²

2022

MedPharmRes

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Introduction: Tumor and pseudotumor (TP) at the proximal femur (PF) can seriously affect mortality, extremity function, and body integrity. However, reports often focused on a specific tumor, not regional lesions. This study focuses on clinical findings, imaging, micro-pathology, and the treatment of all TP at the site. Methods: The study involved all patients who had a confirmed tumor or pseudotumor diagnosis at the PF. The clinical findings, X-ray, and biopsy were recorded and analyzed. Treatment was optional depending on the patient's situation and available condition of the hospital. The functional outcome, bone healing were defined at the last examination or two years of follow-up. Results: Fifty patients were involved in the study. Twenty-four patients had apparent tumors. TP at the PF, neck-trochanter, trochanters, and neck were 21 (42%), 16 (32%), 9 (18%), and 4 (8%) cases, respectively. There were 29 (58%) pathologic fractures. Biopsy was made for all patients. Twenty-three cases (46%) were malignant, and 8 (16%) cases were giant cell tumors. Thirtythree patients suffered from an operation. Ennerking's functional score was excellent, good, fair, and poor in 24 (48%), 5 (10%), 1 (2%), and 20 (40%) patients, respectively. For the last outcomes of 33 operated patients, 17 healed, three unchanged, one worse, and two dead. Conclusions: For the PF TP, the rate of malignant and pathological fracture was high. The giant cell tumor was not rare. The resection of the TP combined with grafts using ordinary fixation devices was satisfactory.

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Section: Discussionmentioning

confidence: 76%

Case series study: the diagnosis and treatment of fifty tumors and pseudotumors at the proximal femur

Van¹,

Cao²

2022

MedPharmRes

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“…La dysplasie fibreuse est habituellement divisée en trois formes cliniques principales: la forme monostotique, la forme polyostotique et la forme avec endocrinopathie (syndrome de Mc Cune-Albright). Les formes polyostotiques ont une symptomatologie plus marquée et se révèlent plus précocement que les formes monostotiques [ 2 ].…”

Section: Discussionunclassified

“…Certains auteurs ont démontré l'efficacité des bisphosphonates sur la diminution du nombre de fractures et sur l'amélioration de la qualité de l'os dans les formes associées ou non à un syndrome de Mc Cune-Albright [ 2 ]. Il faut noter la place actuellement validée des bisphosphonates de nouvelle génération, tel que le pamidronate intraveineux, qui ont montré leur efficacité sur les douleurs et la reprise d'une densité osseuse satisfaisante [ 3 ].…”

Section: Discussionunclassified

“…La dysplasie fibreuse osseuse initialement décrite par Jaffe et Lichtenstein est un néoplasme bénin non transmissible du squelette osseux secondaire à une mutation activatrice du gène GNAS1 [ 1 ]. Il s'agit d'une affection tumorale bénigne, une néoformation intra-osseuse fibreuse pouvant toucher n'importe quelle segment osseux et entraîner un amincissement des corticales et donc une fragilisation osseuse [ 2 ]. Deux formes sont décrites selon le nombre de localisations: à la rare forme polyostotique s'oppose la classique forme monostotique qui représente 88% [ 1 ].…”

Section: Introductionunclassified

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Dysplasie fibreuse polyostotique unilatérale du membre supérieur

Boufettal¹,

Azouz²,

Mahfoud³

et al. 2014

Pan Afr Med J

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La dysplasie fibreuse est une maladie osseuse sporadique rare d’étiologie inconnue qui représente environ 2,5% des maladies osseuses et 7% des tumeurs osseuses bénignes. Cette lésion bénigne pseudotumorale se caractérise par la présence dans l'os d'une prolifération de tissu fibreux et de tissu osseux immature dépourvu de couronne ostéoblastique. Elle peut atteindre un ou plusieurs os; l'atteinte du membre supérieur est rarement décrite, nous rapportons ici un cas rare de dysplasie fibreuse polyostotique unilatérale du membre supérieure.

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“…A retrospective study from the DuPont Institute that included twenty-two subjects, all of whom were younger than eighteen years of age at presentation, found that curettage and bone-grafting using either morselized allograft or autograft did not improve the surgical results beyond what was achieved by mechanical fixation 15 . Additional reports of bone-grafting in fibrous dysplasia have included case reports and small series with short followup and sometimes included bone diseases other than fibrous dysplasia in the analysis [17][18][19][20][21][22][23][24] . Important factors in comparing the outcomes in these studies are the extent of fibrous dysplasia (monostotic fibrous dysplasia or polyostotic fibrous dysplasia), the age of the subjects, and the presence or absence of concomitant endocrine dysfunction as part of the McCune-Albright syndrome.…”

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confidence: 99%

Bone-Grafting in Polyostotic Fibrous Dysplasia

Leet¹,

Boyce

Ibrahim

et al. 2016

The Journal of Bone and Joint Surgery

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Bone-grafting, including both allograft and autograft, is of limited value in ablating the lesions of fibrous dysplasia. The expectations of patients and surgeons should include the high probability of graft resorption over time with return of bone characteristics of fibrous dysplasia, particularly in younger patients. This suggests the maintenance of normal bone mechanics with implant support should be the priority of any surgical intervention.

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La dysplasie fibreuse de l’extrémité proximale du fémur chez l’enfant et l’adolescent

Cited by 8 publications

References 14 publications

Case series study: the diagnosis and treatment of fifty tumors and pseudotumors at the proximal femur

Case series study: the diagnosis and treatment of fifty tumors and pseudotumors at the proximal femur

Dysplasie fibreuse polyostotique unilatérale du membre supérieur

Bone-Grafting in Polyostotic Fibrous Dysplasia

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