¿La exposición crónica al alcohol induce neurodegeneración en el Sistema Nervioso Central de la rata?

Abstract

BackgroundChronic alcohol exposure is associated to neurotoxic and neurodegenerative mechanisms that lead to several cognitive and memory dysfunctions. Alcohol-induced damage depends on ethanol consumption patterns. Prolonged alcohol exposure induces damage in distinct brain regions (prefrontal, perirhinal, entorhinal and parahippocampal cortices, thalamus, hypothalamus, hippocampus and cerebellum) in both alcoholic patients and animal models of alcoholism. However, brain areas of the drug reinforcement and reward circuit have not been investigated.

Bioactive potentialities of Grewia flavescens root extract in the treatment of alcohol dependence: Preliminary phytochemical study

“…Regarding the antidepressant action of flavonoids, note that this is reported in the works of [34]. This author reported the antidepressant activity of Rutin, a Flavonoid, in rats and through co-administration experiments with Serotonin and Noradrenaline inhibitors.…”

“…This author reported the antidepressant activity of Rutin, a Flavonoid, in rats and through co-administration experiments with Serotonin and Noradrenaline inhibitors. According to [34], several studies that show the antidepressant role of Flavonoids have been published, and recently we can cite those of [35,36,37].…”