La expresión de 8-hidroxi 2’-desoxiguanosina en el cáncer

Abstract

The production of reactive oxygen species
 (ROS) takes place in all organisms. ROS regulate the cell
 cycle and other biological phenomena that make them
 essential for life. However, when there is a ROS excess
 and/or the antioxidant system is reduced, oxidative stress
 is induced. During this process, ROS can attack various
 biomolecules and generate oxidative damage. The hydroxyl
 radical is a highly reactive ROS that can react with guanine
 in deoxyribonucleic acid (DNA), generating the molecule
 8-hydroxy-2’-deoxyguanosine (8-OHdG), a marker of
 oxidative damage to DNA. Some research have shown that
 cancer patients or mouse models of cancer have elevated
 levels of 8-OHdG in serum, urine, saliva, and tissues. This
 literature review summarizes the main findings of 8-OHdG
 in several types of cancer and shows the evidence for the
 potential use of 8-OHdG as a biomarker of oxidative DNA
 damage in cancer.

Polimorfismo <i>Ser326Cis</i> de la 8-oxoguanina ADN glucosilasa 1 (OGG 1) en hombres con teratozoospermia

“…Las oxidaciones al ADN espermático son más frecuentes en las bases nitrogenadas, de las cuales la guanina es la más afectada 8 . Estas reacciones a la guanina crean una base modificada denominada 8-hidroxi-2'-desoxiguanosina (8-OHdG); esta molécula se considera un marcador de daño oxidativo confiable 9 . El organismo tiene mecanismos de protección contra la 8-OHdG mediante una reparación a cargo de la enzima 8-oxoguanina ADN glucosilasa 1 (OGG1).…”