La hipótesis de Pedersen no es suficiente: Otros nutrientes además de la glucosaexplicarían la macrosomía fetal enpacientes diabéticas gestacionales consobrepeso y buen control glicémico

Olmos, Pablo; Martelo, Grettel; Reimer, Verena; Rigotti, Attilio; Busso, Dolores; Belmar, Cristián; González, Rogelio; Goldenberg, Denisse; Samith, Bárbara; Santos, José Luís; Escalona, Manuel; Quezada, Thomas; Faúndez, Jorge; Nicklitschek, Ian

doi:10.4067/s0034-98872013001100011

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…This conclusion was reached on the basis of a lower free fatty acids AUC for the HC/LF(CHOICE) diet (19%, P <0.01). Other studies have shown similar results, suggesting that higher levels of carbohydrate with concomitant lower levels of fat produce favorable outcomes ( 3 , 5 , 8 , 9 , 12 , 15 , 23 ).…”

mentioning

confidence: 52%

Macronutrient Composition or Social Determinants? Impact on Infant Outcomes With Gestational Diabetes Mellitus

et al. 2016

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The purpose of this study was to examine, through a randomized, controlled trial, the effects of a maternal carbohydrate-restricted diet on maternal and infant outcomes in gestational diabetes mellitus (GDM). Women diagnosed with GDM were randomly allocated into one of two groups: an intervention group that was placed on a lower-carbohydrate diet (35–40% of total calories) or a control group that was placed on the usual pregnancy diet (50–55% carbohydrate). A convenience sample of participants diagnosed with GDM (ages 18–45 years) was recruited from two different sites: one urban and low-income and the other suburban and more affluent. Individual face-to-face diet instruction occurred with certified diabetes educators at both sites. Participants tested their blood glucose four times daily. Specific socioeconomic status indicators included enrollment in the Supplemental Nutrition Program for Women, Infants and Children or Medicaid-funded health insurance, as well as cross-sectional census data. All analyses were based on an intention to treat. Although there were no differences found between the lower-carbohydrate and usual-care diets in terms of blood glucose or maternal-infant outcomes, there were significant differences noted between the two sites. There was a lower mean postprandial blood glucose (100.59 ± 7.3 mg/dL) at the suburban site compared to the urban site (116.3 ± 15 mg/dL) (P <0.01), even though there was no difference in carbohydrate intake. There were increased amounts of protein and fat consumed at the suburban site (P <0.01), as well as lower infant complications (P <0.01). Further research is needed to determine whether these disparities in outcomes were the result of macronutrient proportions or environmental conditions.

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confidence: 52%

Macronutrient Composition or Social Determinants? Impact on Infant Outcomes With Gestational Diabetes Mellitus

et al. 2016

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“…In pathological pregnancies, complications with diabetes, hypertension, proteinuria or even renal failure are often reported. [25][26][27][28][29][30][31] Although couples of theories are suggested to explain the cross-talk between the enlarged uterus and other abdominal organs, a simple and more straightforward hypothesis Notes: The alterations of large number of chemicals, including insulin, lipid related components, renin, angiotensin, and sex hormones, may simply reflect pathological changes of the abdominal organs in responding to increased pressure. Although one may argue that these chemicals are the direct causes of metabolic syndrome, this is highly unlikely due to the large number of various chemicals involved.…”

Section: Increased Abdominal Pressure Responsible For Mutual Relationmentioning

confidence: 98%

Over Genomics: Physical and Chemical Links of Obesity to Human Diseases

Zhang¹,

Li²

2015

gene editing

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Obesity is associated with increased incidences of human diseases, and significantly shortens life span of both males and females. Metabolic syndrome is tightly associated with obesity albeit their diagnostic standards are different. Although a small portion of patients with metabolic syndrome do not meet the global obesity standard, central obesity generally exists in individuals with metabolic syndrome. Here a hypothesis that central obesity is the cause of metabolic syndrome is suggested. The abnormal accumulation of fatty acids within and around the abdominal organs increases pressure at both organ and cellular levels. Sensing and responding to these increased pressures, cellular synthesis and/or secretion of a variety of chemical mediators are altered, by which diabetes, renal diseases, coronary artery disease, adipose liver, and preeclampsia are developed or augmented. Thus, these multiple organ dysfunction may be referred as abdominal hyperbarism syndrome.

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“…El primer caso de diabetes en el embarazo fue descrito por el doctor Bennewitz en 1824, se trató de una gestante que desarrollo DM presentando síntomas de polidipsia y poliuria, además una glucosuria de 125 g/L que desaparecieron luego del parto, (28) la presencia de varios casos posteriores en Estados Unidos y Reino Unido señaló una alta tasa de mortalidad perinatal en mujeres con diabetes en el embarazo. En 1909 Williams dio a conocer los posibles primeros criterios de diagnóstico por lo que propuso umbrales fisiopatológicos y fisiológicos para una glucosuria transitoria en las gestantes.…”

Section: Antecedentesunclassified

Emerging biomarkers in gestational diabetes: perspectives for improving diagnosis and prognoses

Miranda Sánchez,

Moina Veloz

2024

Salud, Ciencia y Tecnología

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La diabetes mellitus gestacional es una patología que sufre uno de cada siete gestantes a nivel mundial, en la cual el metabolismo de los carbohidratos se encuentra alterado, es decir, se produce una intolerancia a la glucosa. Es reconocida por primera vez en el embarazo ya que estas adaptaciones ocurren con el objetivo de brindar una cantidad adecuada de glucosa al feto para su desarrollo. Se relaciona con factores de riesgo como la edad, dieta, falta de actividad física entre otras y puede ser causante de macrosomía fetal, ictericia neonatal y complicaciones cardiorrespiratorias en la madre. Es diagnosticada mediante distintos análisis de glucosa en sangre como la prueba de tolerancia oral a la glucosa, test de O’ Sullivan, sin embargo en la actualidad se han implementado nuevos biomarcadores para un pronóstico temprano como la IL-6, proteína transportadora de retinol 4, fetuina A materna, proteína C reactiva de alta sensibilidad y biomarcadores moleculares, pero se requieren más estudios para que estos marcadores bioquímicos puedan ser estandarizados por una organización.

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La hipótesis de Pedersen no es suficiente: Otros nutrientes además de la glucosaexplicarían la macrosomía fetal enpacientes diabéticas gestacionales consobrepeso y buen control glicémico

Abstract: La hipótesis de Pedersen no es suficiente:Otros nutrientes además de la glucosa explicarían la macrosomía fetal en pacientes diabéticas gestacionales con sobrepeso y buen control glicémico

Cited by 11 publications

References 33 publications

Macronutrient Composition or Social Determinants? Impact on Infant Outcomes With Gestational Diabetes Mellitus

Macronutrient Composition or Social Determinants? Impact on Infant Outcomes With Gestational Diabetes Mellitus

Over Genomics: Physical and Chemical Links of Obesity to Human Diseases

Emerging biomarkers in gestational diabetes: perspectives for improving diagnosis and prognoses

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