La linfangiogénesis. Sus implicaciones en el diagnóstico, tratamiento y pronóstico del melanoma

Pastushenko, Ievgenia; Conejero, C.; Carapeto, F.J.

doi:10.1016/j.ad.2014.02.013

Cited by 9 publications

(12 citation statements)

References 70 publications

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“…A study performed by Liu and colleagues established the contribution of VEGF‐C and D in promoting lymphangiogenesis and lymph node metastasis 64 . The continuous overexpression of these factors by tumour cells and stroma promotes lymph vessel growth cultivating metastasis 59 . In a melanoma clinical study, VEGF‐C overexpression correlated with SLN spread 65 .…”

Section: Growth Factors That Activate Intracellular Signalling Pathwaysmentioning

confidence: 99%

“…59 However, a soluble VEGFR-3 inhibitor minimised tumour induced lymphangiogenesis and metastasis. 59 Several tumours express elevated concentrations of growth factor C and/or D with growth factor expression paralleling lymphatic vessel density (LVD), lymphatic metastasis and disease outcome. 66 From these studies it is evident that the VEGF-C/VEGFR-3 signalling pathway is significant in fostering a metastatic niche by promoting lymphatic metastasis.…”

Section: Role Of Vegf-c/vegfr-3 Signalling Pathway In Promoting Lymph...mentioning

confidence: 99%

“…63 In the past, limited knowledge and research of lymphatic molecular markers impeded research that would allow researchers to distinguish blood vessels from lymphatic vasculature in the TME and thus elucidate lymphatic metastasis. 59,62 However, the emergence of VEGF-C and D, their receptors and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), a lymphatic specific marker, has contributed to the significance of the lymphatic vasculature in promoting metastasis in various malignancies including melanoma. 59,62 A study performed by Liu and colleagues established the contribution of VEGF-C and D in promoting lymphangiogenesis and lymph node metastasis.…”

Section: Role Of Vegf-c/vegfr-3 Signalling Pathway In Promoting Lymph...mentioning

confidence: 99%

“…In a melanoma clinical study, VEGF‐C overexpression correlated with SLN spread 65 . Additionally, a melanoma animal model observed a positive relation between overexpressed VEGF‐C and lymphatic vessel quantity and peritumoral vessel diameter 59 . However, a soluble VEGFR‐3 inhibitor minimised tumour induced lymphangiogenesis and metastasis 59 .…”

Section: Growth Factors That Activate Intracellular Signalling Pathwaysmentioning

confidence: 99%

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Decoding the synergistic potential of MAZ‐51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals

Letsoalo,

Nortje,

Patrick

et al. 2024

Cell Biochemistry & Function

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Melanoma, an invasive class of skin cancer, originates from mutations in melanocytes, the pigment‐producing cells. Globally, approximately 132,000 new cases are reported each year, and in South Africa, the incidence stands at 2.7 per 100,000 people, signifying a worrisome surge in melanoma rates. Therefore, there is a need to explore treatment modalities that will target melanoma's signalling pathways. Melanoma metastasis is aided by ligand activity of transforming growth factor‐beta 1 (TGF‐β1), vascular endothelial growth factor‐C (VEGF‐C) and C‐X‐C chemokine ligand 12 (CXCL12) which bind to their receptors and promote tumour cell survival, lymphangiogenesis and chemotaxis. (3‐(4‐dimethylaminonaphthelen‐1‐ylmethylene)‐1,3‐dihydroindol‐2‐one) MAZ‐51 is an indolinone‐based molecule that inhibits VEGF‐C induced phosphorylation of vascular endothelial growth factor receptor 3 (VEGFR‐3). Despite the successful use of conventional cancer therapies, patients endure adverse side effects and cancer drug resistance. Moreover, conventional therapies are toxic to the environment and caregivers. The use of medicinal plants and their phytochemical constituents in cancer treatment strategies has become more widespread because of the rise in drug resistance and the development of unfavourable side effects. Zingerone, a phytochemical derived from ginger exhibits various pharmacological properties positioning it as a promising candidate for cancer treatment. This review provides an overview of melanoma biology and the intracellular signalling pathways promoting cell survival, proliferation and adhesion. There is a need to align health and environmental objectives within sustainable development goals 3 (good health and well‐being), 13 (climate action) and 15 (life on land) to promote early detection of skin cancer, enhance sun‐safe practices, mitigation of environmental factors and advancing the preservation of biodiversity, including medicinal plants. Thus, this review discusses the impact of cytostatic cancer drugs on patients and the environment and examines the potential use of phytochemicals as adjuvant therapy.

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Section: Growth Factors That Activate Intracellular Signalling Pathwaysmentioning

confidence: 99%

Section: Role Of Vegf-c/vegfr-3 Signalling Pathway In Promoting Lymph...mentioning

confidence: 99%

Section: Role Of Vegf-c/vegfr-3 Signalling Pathway In Promoting Lymph...mentioning

confidence: 99%

Section: Growth Factors That Activate Intracellular Signalling Pathwaysmentioning

confidence: 99%

See 2 more Smart Citations

Decoding the synergistic potential of MAZ‐51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals

Letsoalo,

Nortje,

Patrick

et al. 2024

Cell Biochemistry & Function

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“…Nowadays, melanoma remains the leading cause of skin cancers-related death owing to its high metastasis 3 , 4 . Despite the development of treatments 5 , 6 , the prognosis of patients with melanoma still disappointing 7 , 8 . Thus, discovering novel molecules and developing new effective therapeutic targets are of great significance to improve the prognosis in melanoma patients.…”

Section: Introductionmentioning

confidence: 99%

Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61

et al. 2020

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Circular RNAs (circRNAs) are emerging regulators in the development of human cancers. However, the role of circRNAs in melanoma is poorly understood. Microarray analysis and qRT-PCR was applied to screen out circRNAs that were differentially expressed in melanoma cells compared to normal cells. Currently, we first proved that inhibition of CYR61, an angiogenesis factor with controversial functions in melanoma, restrained cell migration, invasion and angiogenesis in melanoma. Thereafter, a novel circRNA hsa_circ_0027247 derived from GLI1 (circ-GLI1) was identified to positively modulate CYR61 expression in melanoma cell lines. Besides, silencing circ-GLI1 hindered melanoma cell metastasis as well. Interestingly, we unveiled that circ-GLI1 enhanced CYR61 transcription by an indirect manner. Meanwhile, circ-GLI1 activated Hedgehog/GLI1 and Wnt/β-catenin pathways by affecting the degradation of GLI1 and β-catenin. Moreover, we found that circ-GLI1 interacted with p70S6K2 to induce GSK3β phosphorylation at Ser9, and therefore blocked the binding of GSK3β with GLI1 and β-catenin so as to elevate their protein expression. Of note, CYR61 was transcriptionally activated by MYC, a well-recognized downstream target of both GLI1 and β-catenin. In conclusion, circ-GLI1 exacerbates the metastasis and angiogenesis of melanoma by upregulating Cyr61 via p70S6K2-dependent activation of Hedgehog/GLI1 and Wnt/β-catenin pathways.

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Long noncoding RNA CPS1‐IT1 suppresses melanoma cell metastasis through inhibiting Cyr61 via competitively binding to BRG1

Zhou

Rao

Qilin

et al. 2019

Journal Cellular Physiology

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Long noncoding RNA CPS1-IT1 is recently recognized as a tumor suppressor in several cancers. Here, we investigate the role of CPS1-IT1 in human melanoma.Presently, our study reveals the low expression of CPS1-IT1 in human melanoma tissues and cell lines, which is significantly associated with metastasis and tumor stage. Besides, the potential of CPS1-IT1 as a prognosis-predictor is strongly indicated. Functionally, CPS1-IT1 overexpression inhibits cell migration, invasion, epithelial-mesenchymal transition, and angiogenesis in melanoma cells. CYR61, an angiogenic factor that participates in tumor metastasis as well as a recognized oncogene in melanoma, is shown to be confined under CPS1-IT1 overexpression in melanoma cells. Furthermore, enforced expression of Cyr61 in CPS1-IT1-silenced melanoma cells dramatically normalized the protein level of Cyr61 and that of its downstream targets vascular endothelial growth factor and matrix metalloproteinase-9, as well as the repressive effect of CPS1-IT1 overexpression on melanoma cell metastasis. BRG1, a core component of SWI/SNF complex, is implied to interact with both CPS1-IT1 and Cyr61 in melanoma cells. Moreover, CPS1-IT1 negatively regulates Cyr61 expression by blocking the binding of BRG1 to Cyr61 promoter. Jointly, CPS1-IT1 controls melanoma metastasis through impairing Cyr61 expression via competitively binding with BRG1, uncovering a novel potential therapeutic and prognostic biomarker for patients with melanoma. K E Y W O R D SBRG1, CPS1-IT1, Cyr61, melanoma, metastasis

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La linfangiogénesis. Sus implicaciones en el diagnóstico, tratamiento y pronóstico del melanoma

Cited by 9 publications

References 70 publications

Decoding the synergistic potential of MAZ‐51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals

Decoding the synergistic potential of MAZ‐51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals

Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61

Long noncoding RNA CPS1‐IT1 suppresses melanoma cell metastasis through inhibiting Cyr61 via competitively binding to BRG1

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