La mala calidad de sueño se asocia a una menor adherencia al tratamiento antirretroviral de gran actividad en pacientes peruanos con infección por VIH/SIDA

Tello-Velásquez, Jorge Renzo; Díaz-Llanes, Bruno Eduardo; Mezones‐Holguín, Edward; Rodríguez‐Morales, Alfonso J.; Huamaní, Charles; Hernández, Adrian V.; Arévalo-Abanto, Jorge

doi:10.1590/0102-311x00010014

Cited by 13 publications

(10 citation statements)

References 58 publications

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“…The flow diagram of study selection is shown in Figure . Fifty‐three studies, composed of 22,603 participants in ART from 25 LAC countries, met eligibility criteria for the systematic review (Table ) . The median number of participants in ART per study was 201 [range: 13 – 3343; interquartile range (IQR): 394 – 125].…”

Section: Resultsmentioning

confidence: 99%

Adherence to antiretroviral therapy for HIV/AIDS in Latin America and the Caribbean: Systematic review and meta‐analysis

et al. 2018

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IntroductionOptimal adherence to antiretroviral therapy is closely related with suppression of the HIV viral load in plasma, slowing disease progression and decreasing HIV transmission rates. Despite its importance, the estimated proportion of people living with HIV in Latin America and the Caribbean with optimal adherence has not yet been reported in a meta‐analysis. Moreover, little is known of the factors leading to poor adherence which may be setting‐specific. We present a pooled estimate of adherence to antiretroviral therapy (ART) of people living with HIV in Latin America and Caribbean, report the methods used to measure adherence and describe the factors associated with poor adherence among the selected studies.MethodsWe electronically searched published studies up to July 2016 on the PubMed, Web of Science and Virtual Health Library (Latin America and the Caribbean Regional Portal); considering the following databases: MEDLINE, LILACS, PAHO and IBECS. Two independent reviewers selected and extracted data on ART adherence and study characteristics. Pooled estimate of adherence was derived using a random‐effects model. Risk of bias in individual studies was assessed independently by two investigators using the Risk of Bias Assessment tool for Non‐randomized Studies (RoBANS).Results and discussionThe meta‐analysis included 53 studies published between 2005 and 2016, which analysed 22,603 people living with HIV in 25 Latin America and Caribbean countries. Overall adherence in Latin America and Caribbean was 70% (95% CI: 63–76; I 2 = 98%), similar to levels identified by studies conducted in high‐income regions. Self‐report was the most frequently used method to measure adherence. Subgroup analysis showed that adherence was higher for the shortest recall time frame used, as well as in countries with lower income level, Gross National Income (GNI) per capita and Human Development Index (HDI). Studies reported diverse adherence barriers, such as alcohol and substance misuse, depression, unemployment and pill burden.ConclusionsOur study suggests that adherence to ART in Latin America and Caribbean may be below the sufficient levels required for a successful long‐term viral load suppression.

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Section: Resultsmentioning

confidence: 99%

Adherence to antiretroviral therapy for HIV/AIDS in Latin America and the Caribbean: Systematic review and meta‐analysis

et al. 2018

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“…Em outros países onde o CEAT-VIH também foi utilizado, e apesar de apresentarem características distintas, os resultados mostraram-se próximos ao deste estudo quanto à avaliação da adesão. Na Romênia e na Colômbia, a adesão estrita foi descrita em 15% da população estudada, todavia, no Peru, o percentual aumentou para 25,5% [14][15][16] . , v. 11, n. 2, p. 307-314, maio/agosto 2018 -ISSN 1983-1870 -e-ISSN 2176-9206 Assim, por a adesão ser considerada um processo multifatorial, dinâmico e variável, e estar implicada a um conjunto de características e ações que podem ou não interferir na ingestão dos medicamentos antirretrovirais, ressalta-se a importância dos serviços de saúde em realizar constantemente a avaliação da adesão 7 .…”

Section: Discussionunclassified

“…Outro fator que dificulta a adesão é o fato de as pessoas realizaram esforços ou de até que ponto se sentem capazes de seguir o tratamento. As pessoas que necessitam realizar um esforço maior para realizar o tratamento acabam, por vezes, não o realizando adequadamente 16 . Além disso, o apoio insuficiente do meio social e familiar parece afetar negativamente a adesão, encaminhando o paciente à depressão e à desesperança.…”

Section: Discussionunclassified

Avaliação Da Adesão Ao Tratamento Antirretroviral De Pessoas Vivendo Com Hiv

et al. 2018

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Avaliar a adesão ao tratamento antirretroviral de pessoas que vivem com HIV através do “Cuestionario para la Evaluación de la Adhesión al Tratamiento Antiretroviral” (CEAT-VIH), de forma a descrever seus itens a partir da correlação entres as questões deste instrumento. Estudo transversal, realizado em um Hospital Universitário do Rio Grande do Sul no primeiro semestre de 2012 com 179 pessoas em tratamento para o HIV. Foram realizadas análises estatísticas descritivas e de correlação entre os itens do questionário. Avaliação da adesão: 46,4% baixa/insuficiente, 36,9% boa/adequada e 16,8% estrita. Correlações: deixar de tomar a medicação relaciona-se aos fatos de se sentir melhor/pior, ou sentir-se triste/deprimido. Seguir a prescrição médica está relacionado com a autoavaliação em relação à ingesta dos medicamentos. A baixa/inadequada adesão legitima o uso do CEAT-VIH enquanto ferramenta a ser utilizada pela enfermagem junto à equipe multiprofissional no planejamento do cuidado e intervenção nas situações que interferem na adesão.

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“…Poor sleep quality is associated with several adverse consequences in the HIV-infected population. These consequences include impact on ART adherence, decreased engagement in HIV-care, diminished health-related quality of life, excessive daytime sleepiness, and cognitive impairment (Tedaldi, Minniti, & Fischer, 2015;Tello-Velasquez et al, 2015;Vosvick et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with poor sleep quality among HIV-positive individuals in Mexico City

Estrada

Chiesa

Orellana

et al. 2018

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Introduction. Sleep quality is commonly impaired in medical disorders, and the HIV-positive population is particularly vulnerable to complaint from sleep disturbances. Objective. To determine the prevalence of poor sleep quality and the factors associated with it, in a population of HIV positive Mexican out patients. Method. A cross sectional study was done. A sample of 367 HIV-positive subjects over 18 years completed a set of self-administered questionnaires: the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale, the Athens Insomnia Scale, and the Beck Depression Inventory. Sociodemographic and clinical data were recorded. Results. Of the respondents, 82.8% (n = 304) were male. The mean age of the patients was 36.6 (SD = 9.4) years, and the mean educational level was 12.2 (SD = 3.8) years. According to the PSQI, 58.6% (n = 215) had poor sleep quality. Poor sleep quality was more common in those who had lived longer with HIV, had started their antiretroviral treatment later, had suboptimal antiretroviral adherence, had a CD4 cell count < 200 cells/µL, reported illicit drug use, had concomitant medications, or had insomnia, sleepiness, or depressive symptoms. In multivariate analyses, poor sleep quality was associated with depressive symptoms, illicit drug use, a CD4 count < 200 cells/µL, and time elapsed since HIV diagnosis. Discussion and conclusion. Poor sleep quality is common in HIV patients. Early identification of patients with poor sleep quality through vigilance for factors associated with it might facilitate prompt treatment.

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La mala calidad de sueño se asocia a una menor adherencia al tratamiento antirretroviral de gran actividad en pacientes peruanos con infección por VIH/SIDA

Cited by 13 publications

References 58 publications

Adherence to antiretroviral therapy for HIV/AIDS in Latin America and the Caribbean: Systematic review and meta‐analysis

Adherence to antiretroviral therapy for HIV/AIDS in Latin America and the Caribbean: Systematic review and meta‐analysis

Avaliação Da Adesão Ao Tratamento Antirretroviral De Pessoas Vivendo Com Hiv

Factors associated with poor sleep quality among HIV-positive individuals in Mexico City

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