La mort subite cardiovasculaire de l’adulte : étude autopsique de 361 cas

Mesrati, Med Amin; Belhadj, M.; Aissaoui, Abir; HajSalem, N.; Oualha, Dorra; Boughattas, Meriem; Ikram, M. Arfan; Hammedi, Faten; Zakhama, A.; Chadly, Ali

doi:10.1016/j.ancard.2016.03.003

Cited by 16 publications

(8 citation statements)

References 13 publications

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“…As in our study, the summer predominance is comparable to that found in the literature [20].This slight predominance of cases of sudden death during the summer may be related to the excessive heat in our country at this time of year (from June to October).…”

Section: Discussionsupporting

confidence: 89%

Sudden Death in The Young Adult: An Autopsy-Based Series

Saadi

Jomâa

Hadj

et al. 2020

Preprint

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Abstract Background: We aim to study the epidemiological and pathological characteristics of sudden death in young, to determine the etiology of death and to purpose recommendations for prevention. Methods: we performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir. A review of all autopsies performed during 28 years was done. In each case, clinical information and circumstances of death were obtained and a complete forensic autopsy and histological and toxicological investigations were performed. We have included all sudden death in persons aged between 18 years and 35 years.Results: we collected 137 cases of sudden death during studied period. The mean age of the studied population was 26.47 years. In 72.6% death was classified as cardiac death and was due to ischemic heart disease in 32.32%. Sudden death was attributed to a pleuropulmonary cause in 7.4%, an abdominal cause in 6% and from a neurological origin in 4.5%. The cause of sudden death in this group was not established in 9.5%.Conclusion: there are several potential causes of sudden unexplained death such as structural abnormalities, ion channels abnormalities. Unexplained deaths, presumed to result from sudden primary arrhythmogenic causes, occur in young adult with structurally normal hearts. That underlying disease-causing genetic defects may be involved has clinical implications for family members. Our findings suggest that prevention of sudden death among young adults under the age of 35 years should also focus on evaluation for causes not associated with structural heart disease.

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Section: Discussionsupporting

confidence: 89%

Sudden Death in The Young Adult: An Autopsy-Based Series

Saadi

Jomâa

Hadj

et al. 2020

Preprint

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“…80 cases of PTE constituted 1.8% of all autopsies (4533 cases). Similar PTE rates were observed in other studies: 1.2% in an analogous study by Lucena et al (2007), and 1.9% in a cardiovascular mortality study by Mesrati et al (2017). The negligible difference might be explained by the widespread prevalence of cardiovascular diseases (CVDs).…”

Section: Resultssupporting

confidence: 84%

Epidemiology and Risk Factors of Sudden Death Due to Pulmonary Thromboembolism: A Retrospective Study

Šimakauskas

Baltuonis

Laima

et al. 2019

CBUP

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Introduction. Pulmonary thromboembolism (PTE) is not an uncommon cause of sudden, unexpected death. Autopsy is the gold standard for cause of death determination in cases of suspected PTE. Mortality rates due to PTE are not estimated accurately. Objective. The aim of this study was to analyze distribution patterns and risk factors of sudden deaths due to PTE. Methods. Retrospective analysis of Lithuanian State Forensic Medicine Service autopsy data, period 2014-2018. A total of 4533 cases were reviewed; 80 cases met the criteria of immediate cause of death being PTE and were included in the study. PTE epidemiology, risk factors, clinical and pathoanatomical characteristics were described by reviewing scientific literature and statistical databases. Results. PTE as the cause of sudden death was diagnosed in 37(46.25%) men and 43(53.75%) women. Median age at the time of death was 62.8±17.2 years. Death occurred in hospital in 21(26.25%) cases. Trauma was the underlying cause of PTE in 11(13.75%) cases; 9(81.8%) patients were admitted to hospital after a traumatic event. Cardiac hypertrophy was observed in 70(87.5%) autopsies. Abdominal subcutaneous fat thickness was 4.08±2.64 cm in men and 5.35±2.69 cm in women. Deep vein thrombosis (DVT) was confirmed upon microscopic examination in all cases, being the underlying cause of death in 67(83.75%) cases. Conclusion. Sudden death due to PTE usually occurs at an older age and in absence of medical care. PTE is common after sustaining severe traumatic injuries which, when not immediately lethal, are managed in hospital. Cardiac hypertrophy and obesity may increase risk of death due to PTE. Undiagnosed and untreated DVT is often the underlying cause of sudden death due to PTE.

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“…As in our study, the summer predominance is comparable to that found in the literature [22,23]. This slight predominance of cases of sudden death during the summer may be related to the excessive heat in our country at this time of year (from June to October).…”

Section: Discussionsupporting

confidence: 89%

Sudden death in the young adult: An autopsy-based series

Saadi

Jomâa

Hadj

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: We aim to study the profile, and pathological characteristics of sudden death in young in purpose of recommendations for prevention. Methods: We performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir (Tunisia). A review of all autopsies performed for 28 years was done. In each case, clinical information, and circumstances of death were obtained. A complete forensic autopsy and histological, and toxicological investigations were performed. We have included all sudden death in persons aged between 18 years and 35 years.Results: We collected 137 cases of sudden death during the studied period. The mean age of the studied population was 26.47 years. Almost 72% deaths were classified as cardiac death, and was due to ischemic heart disease in 32.32%. Sudden death was attributed to a pleuropulmonary cause in 7.4%, an abdominal cause in 6%, and from a neurological origin in 4.5%. The cause of sudden death in this group was not established by 9.5%.Conclusion: There are several potential causes of sudden unexplained death such as structural abnormalities, ion channel abnormalities. Unexplained deaths, presumed to result from sudden primary arrhythmogenic causes, occur in a young adult with structurally normal hearts. That underlying disease-causing genetic defects may be involved has clinical implications for family members. Our findings suggest that prevention of sudden death among young adults under the age of 35 years should also focus on evaluation for causes not associated with structural heart disease.

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La mort subite cardiovasculaire de l’adulte : étude autopsique de 361 cas

Cited by 16 publications

References 13 publications

Sudden Death in The Young Adult: An Autopsy-Based Series

Sudden Death in The Young Adult: An Autopsy-Based Series

Epidemiology and Risk Factors of Sudden Death Due to Pulmonary Thromboembolism: A Retrospective Study

Sudden death in the young adult: An autopsy-based series

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