La primo-infection et la tuberculose pulmonaire

Toujani, S.; Salah, N. Ben; Chérif, J.; Mjid, M.; Ouahchy, Y.; Zakhama, H.; Daghfous, J.; Béji, M.; Rhouma, N. Mehiri-Ben; Louzir, B.

doi:10.1016/j.pneumo.2015.02.001

Cited by 10 publications

(7 citation statements)

References 50 publications

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“…Pulmonary tuberculosis (PTB) is the most common form of TB presentation [ 10 ]. Endobronchial tuberculosis (EBTB), which occurs in approximately 10%–40% in all TB patients [ 11 ], occurs when TB presents following infection of the bronchial tubes.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Plasma Cytokine and Chemokine Profiles in Patients with and without Tuberculosis by Liquid Array-Based Multiplexed Immunoassays

et al. 2016

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The aim of this study was to establish plasma cytokine/chemokine profiles in patients with 3 different presentations of active tuberculosis (TB), compared to the profiles observed in bacillus Calmette-Guérin (BCG)-vaccinated healthy individuals and patients with other pulmonary diseases (non-TB patients). To this end, plasma samples were collected from 151 TB patients including 68 pulmonary TB (PTB), 43 endobronchial TB, and 40 tuberculosis pleurisy (TP) patients, as well as 107 no-TB cases including 26 non-TB patients and 81 BCG-vaccinated healthy controls. A liquid array-based multiplexed immunoassay was used to screen plasma samples for 20 distinct cytokines and chemokines. Multinomial logistic regression was used to analyze associations between cytokines/chemokines and TB/non-TB patients. Compared to our findings with the no-TB donors, the median plasma levels of the proinflammatory cytokines/chemokines TNF-α, IL-6, IP-10, IFN-γ, and MIP-1β were significantly elevated in TB patients, suggesting their potential use as biomarkers for diagnosing TB patients. Further comparisons with healthy donors showed that only the median TNF-α plasma level was highly produced in the plasma of all 3 types of TB patients. Plasma IL-6 production was higher only in TP patients, while the plasma levels of IP-10, IFN-γ, and MIP-1β were markedly enhanced in both PTB and TP patients. Unexpectedly, among the above cytokines/chemokines, MIP-1β was also highly expressed in non-TB patients, compared with healthy donors. Our results suggested that TNF-α may be an ideal biomarker for diagnosing the 3 forms of TB presentation, while the other factors (IL-6, IP-10, MCP-1, and IFN-γ) can potentially facilitate differential diagnosis for the 3 TB presentation types. Further characterization of immune responses associated with different types of TB diseases will provide a basis for developing novel TB diagnostics.

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Section: Introductionmentioning

confidence: 99%

Analysis of Plasma Cytokine and Chemokine Profiles in Patients with and without Tuberculosis by Liquid Array-Based Multiplexed Immunoassays

et al. 2016

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“…Nevertheless, attention must be drawn to the importance of Mycobacterium tuberculosis culture and histological exam which remain the only way to confirm the diagnosis and to begin an antibacillary therapy [6]. In fact, the major risk is a reactivation of TB which will lead to active tuberculosis in case of immunodeficiency [7]. However, reduced immunity has been demonstrated in animals after pulmonary contusion, hemorrhagic shock and in cases of severe trauma [8].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Gunshot Wound Revealing Pulmonary Tuberculosis

Issoufou¹

2017

IJOPRS

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Pulmonary tuberculosis is a major flail of mankind, 1/3 of the world population is infected. In Morocco, the incidence is estimated by the Word Health Organization to 89 cases per 100 000 inhabitants. However, gunshot assaults are rare. Many circumstances of discovery of tuberculosis were described. We present the case of an incidental finding of pulmonary tuberculosis in a young patient victim of a gun attack.

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“…La tuberculose (TB) est une maladie contagieuse dont la physiopathologie et la réponse immunitaire observée chez les sujets infectés conduit à deux entités nosologiques : l'infection tuberculeuse latente (ITL) et la tuberculose maladie (TM) [1]. Malgré les nombreuses stratégies de lutte antituberculeuse, la tuberculose représente encore un problème majeur de santé publique dans le monde [2].La tuberculose (TB) est encore au XXIe siècle l'une des principales maladies infectieuses dans le monde [1]. Son incidence est variable dans le monde allant d'une incidence faible entre 0 et 9.9 pour 100 000 habitants par an dans les pays occidentaux (Amérique du nord et Europe), à des incidences extrêmement élevées, supérieures à 500 pour 100 000 habitants par an en Afrique du sud.…”

Section: Introductionunclassified

Profil épidémiologique, diagnostic et évolutif de la tuberculose en milieu communautaire dans le centre de diagnostic et de traitement de Konobougou, Mali.

Coulibaly¹,

Niangaly²,

Keita³

et al. 2020

Rev Mali Infectiol Microbiol

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Introduction : La tuberculose représente encore un problème majeur de santé publique dans le monde et particulièrement en Afrique subsaharien. Le but de ce travail était de déterminer le profil épidémiologique, diagnostic et évolutif des patients suivis pour tuberculose pharmaco-sensible au centre de diagnostic et de traitement du centre de santé communautaire et universitaire de Konobougou dans le district sanitaire de Barouéli au Mali. Méthode et matériels : Il s'agissait d'étude transversale et rétrospective des patients suivis pour tuberculose au centre de diagnostic et de traitement de Konobougou dans le district sanitaire de Barouéli allant du 1er janvier 2017 au 30 juin 2019. Résultats : Nous avons retenu dans cette étude 48 tuberculeux toutes formes confondues. Le sexe masculin a été le plus fréquent soit 79,2% avec un sexe ratio de 3,8. La tuberculose pulmonaire bactériologiquement confirmée représentait 89 ,6% (n=43) et 10,4% (n=5) était extra pulmonaire. La comorbidité tuberculose – VIH représentait 12,5% des patients. Le succès thérapeutique était à 87,9% (n=42). 8,3% de décès, avec 2,1% cas de perdu de vue et 2,1% cas d'échec thérapeutique. Conclusion : La prise en charge de la tuberculose en milieu communautaire par la stratégie du traitement directement observé serait un élément important dans le succès thérapeutique.

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La primo-infection et la tuberculose pulmonaire

Cited by 10 publications

References 50 publications

Analysis of Plasma Cytokine and Chemokine Profiles in Patients with and without Tuberculosis by Liquid Array-Based Multiplexed Immunoassays

Analysis of Plasma Cytokine and Chemokine Profiles in Patients with and without Tuberculosis by Liquid Array-Based Multiplexed Immunoassays

Pulmonary Gunshot Wound Revealing Pulmonary Tuberculosis

Profil épidémiologique, diagnostic et évolutif de la tuberculose en milieu communautaire dans le centre de diagnostic et de traitement de Konobougou, Mali.

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