La réinjection première de graisse autologue en reconstruction mammaire

Irani, Y.; Casanova, D.; Amar, Edouard

doi:10.1016/j.anplas.2010.11.002

Cited by 19 publications

(3 citation statements)

References 41 publications

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“…Several studies have now reported the use and outcome of autologous fat transplantation; patients who had radiation therapy require more lipofilling sessions. 9 , 12 – 14 The complication rate of lipofilling-based protocol seems to be quite low across the different studies, in particular regarding reconstruction failure. Recently, a study by Bennett et al 15 showed a significantly higher rate of complications at 2 years for any flap-based reconstruction compared to prosthesis or expander-based reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Breast Reconstruction Combining Lipofilling and Prepectoral Prosthesis after Radiotherapy

Razzouk

Fitoussi²,

Khori

et al. 2020

Plastic and Reconstructive Surgery - Global Open

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Background: Prosthetic reconstruction in previously irradiated breasts has been associated with a higher risk of complications. Here we describe the surgical and cosmetic outcome of our breast reconstruction process based on primary fat grafting combined with prosthetic placement. Methods: In this multicenter retrospective study, 136 patients who underwent mastectomy and external chest wall radiotherapy between 2014 and 2018 were benefited from chest wall lipofilling and silicone implant placement were chosen. Patients were assessed for skin trophicity, thickness, and mobility and were allowed to undergo several lipofilling sessions before implant placement, if required. No patient had >3 lipofilling sessions. Cosmetic outcome was evaluated by the patient, surgeon, and nurse, using a Likert-type ordinal scale. Results: We included 136 patients: 79 patients (58%) received only 1 session of lipofilling before implant placement, 33 (24.6%) had 2 sessions, and 24 (17.4%) had 3 sessions. The volume of the third lipofilling was significantly higher and the volume of the prosthesis of these patients was significantly lower than those of patients undergoing 1 or 2 lipofillings. Reconstruction failure rate was 2.2% (3 patients had explantation); however, all benefited from prosthesis reconstruction a year after the initial procedures. The average satisfaction score was 4.7 out of 5 as evaluated by patients, 4.8 out of 5 by surgeons, and 4.8 out of 5 by nurses. Conclusions: Primary lipofilling combined with prosthesis placement after radiotherapy is a reconstructive method that yields a satisfactory cosmetic outcome with a low complication rate. Such minimally invasive breast reconstruction approach can be an alternative to flap-based reconstruction.

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Section: Discussionmentioning

confidence: 99%

Breast Reconstruction Combining Lipofilling and Prepectoral Prosthesis after Radiotherapy

Razzouk

Fitoussi²,

Khori

et al. 2020

Plastic and Reconstructive Surgery - Global Open

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“… 57 Their results have been replicated by other authors over the recent years, and ASC (or, more precisely, fat injections) are now being used for both treatment of late radiotherapy damage and as preconditioning treatment in an attempt to decrease surgical complication rates with elective surgery. 58 , 59 …”

Section: Bystander Effectmentioning

confidence: 99%

From bench to bedside: use of human adipose-derived stem cells

Feisst¹,

Meidinger²,

Locke³

2015

SCCAA

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Since the discovery of adipose-derived stem cells (ASC) in human adipose tissue nearly 15 years ago, significant advances have been made in progressing this promising cell therapy tool from the laboratory bench to bedside usage. Standardization of nomenclature around the different cell types used is finally being adopted, which facilitates comparison of results between research groups. In vitro studies have assessed the ability of ASC to undergo mesenchymal differentiation as well as differentiation along alternate lineages (transdifferentiation). Recently, focus has shifted to the immune modulatory and paracrine effects of transplanted ASC, with growing interest in the ASC secretome as a source of clinical effect. Bedside use of ASC is advancing alongside basic research. An increasing number of safety-focused Phase I and Phase IIb trials have been published without identifying any significant risks or adverse events in the short term. Phase III trials to assess efficacy are currently underway. In many countries, regulatory frameworks are being developed to monitor their use and assure their safety. As many trials rely on ASC injected at a distant site from the area of clinical need, strategies to improve the homing and efficacy of transplanted cells are also being explored. This review highlights each of these aspects of the bench-to-bedside use of ASC and summarizes their clinical utility across a variety of medical specialties.

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“…[32,33] In recent years, there were also attempts to use ADSC in the treatment of advanced cancer radiation injury and to reduce the complications after limited operation, which has achieved a certain effect. [34,35] …”

Section: Application In Wound Healingmentioning

confidence: 99%

Advances in the research of basic study and clinical application of adipose-derived mesenchymal stem cells

Sheng-jun

Wang

et al. 2018

DCC

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Since the discovery of adipose-derived mesenchymal stem cell (ADSC) in more than ten years, a great progress has been made from its basic research to clinical application. Compared with bone marrow mesenchymal stem cells, ADSC is more abundant in reserve, easier to obtain with fewer injuries and less complications. These cells have multiple differentiation potential and can differentiate into adipocytes, chondrocytes and osteoblasts with the influence of different inducing factors. Early studies of ADSC mainly focused on the ability of multi-directional differentiation, especially on the regeneration of bone defects and cartilage tissue. At present, the researches mainly focus on immunoregulation and paracrine function of ADSC. Although ADSC has made a great progress in clinical application, the cell preparation, use pattern, and mechanisms in clinical treatment are not clear. This paper elaborates on these issues.

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La réinjection première de graisse autologue en reconstruction mammaire

Cited by 19 publications

References 41 publications

Breast Reconstruction Combining Lipofilling and Prepectoral Prosthesis after Radiotherapy

Breast Reconstruction Combining Lipofilling and Prepectoral Prosthesis after Radiotherapy

From bench to bedside: use of human adipose-derived stem cells

Advances in the research of basic study and clinical application of adipose-derived mesenchymal stem cells

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