La réponse au stress du réticulum endoplasmique dans la physiopathologie des maladies chroniques du foie

Vallée, Déborah; Blanc, Marina; Lebeaupin, Cynthia; Bailly-Maître, Béatrice

doi:10.1051/medsci/2020008

Cited by 11 publications

(2 citation statements)

References 53 publications

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“…In addition, by enhancing inflammatory or apoptotic signalling, ERS may be another mechanism to promote NAFLD. 88,89 The experiments by Zhang et al confirmed this idea. They administered the ERS-inducing agent clathrin tunicamycin intraperitoneally to mice, which resulted in hepatic steatosis with significant increases in ERS markers, including BIP/glucose-regulated protein 78 (BIP/GRP78), CHOP and IRE1α.…”

Section: Paf-mediated Cytokine Involvement In Nafld Paf-5-ht Signalli...mentioning

confidence: 87%

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Yin

Shi

2022

DMSO

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Non-alcoholic fatty liver disease (NAFLD) is a multifaceted clinicopathological syndrome characterised by excessive hepatic lipid accumulation that causes steatosis, excluding alcoholic factors. Platelet-activating factor (PAF), a biologically active lipid transmitter, induces platelet activation upon binding to the PAF receptor. Recent studies have found that PAF is associated with gamma-glutamyl transferase, which is an indicator of liver disease. Moreover, PAF can stimulate hepatic lipid synthesis and cause hypertriglyceridaemia. Furthermore, the knockdown of the PAF receptor gene in the animal models of NAFLD helped reduce the inflammatory response, improve glucose homeostasis and delay the development of NAFLD. These findings suggest that PAF is associated with NAFLD development. According to reports, patients with NAFLD or animal models have marked platelet activation abnormalities, mainly manifested as enhanced platelet adhesion and aggregation and altered blood rheology. Pharmacological interventions were accompanied by remission of abnormal platelet activation and significant improvement in liver function and lipids in the animal model of NAFLD. These confirm that platelet activation may accompany a critical importance in NAFLD development and progression. However, how PAFs are involved in the NAFLD signalling pathway needs further investigation. In this paper, we review the relevant literature in recent years and discuss the role played by PAF in NAFLD development. It is important to elucidate the pathogenesis of NAFLD and to find effective interventions for treatment.

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Section: Paf-mediated Cytokine Involvement In Nafld Paf-5-ht Signalli...mentioning

confidence: 87%

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Yin

Shi

2022

DMSO

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“…28,29 Under ER stress, released GRP78 could activate IRE1α, PERK, and ATF6, as well as their downstream signaling pathways, which promotes inflammation, apoptosis, and activity of related factors, including NF-κB, phosphorylation of eukaryotic initiation factor 2α (eIF2α), and expression of ER stress-related genes and proteins such as ATF4, c-Jun N-terminal kinase (JNK), and C/EBP homologous protein (CHOP), as well as the pro-apoptotic B-cell lymphoma-2 (Bcl-2) family member p53 up-regulated modulator of apoptosis (PUMA) and death protein 5 (DP5). [30][31][32]…”

Section: Metabolic Dysregulation Provides a Favorable Pro-inflammator...mentioning

confidence: 99%

Pathogenesis from Inflammation to Cancer in NASH-Derived HCC

Yu¹,

Wang²,

Zheng³

et al. 2022

JHC

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Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the deadliest cancers worldwide. As opposed to the majority of patients with HCC, approximately 20–30% of cases of non-alcoholic steatohepatitis (NASH)-derived HCC develop malignant tumours in the absence of liver cirrhosis. NASH is characterized by metabolic dysregulation, chronic inflammation and cell death in the liver, which provide a favorable setting for the transformation of inflammation into cancer. This review aims to describe the pathogenesis and the underlying mechanism of the transition from inflammation to cancer in NASH.

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Insights into the role of vitamin D in targeting the culprits of non-alcoholic fatty liver disease

Abdelrahman,

El-Khatib,

Attia

2023

Life Sciences

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La réponse au stress du réticulum endoplasmique dans la physiopathologie des maladies chroniques du foie

Cited by 11 publications

References 53 publications

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Pathogenesis from Inflammation to Cancer in NASH-Derived HCC

Insights into the role of vitamin D in targeting the culprits of non-alcoholic fatty liver disease

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