LA reservoir strain: a sensitive parameter for estimating LV filling pressure in patients with preserved EF

Tan, Türkan Seda; Akbulut, İrem Müge; Demirtola, Ayşe İrem; Serifler, Nazli Turan; Özyüncü, Nil; Esenboğa, Kerim; Kürklü, Hacı Ali; Kozluca, Volkan; Ongun, Aydan; Uludağ, Demet Menekşe Gerede; Tutar, Durmuş Eralp; Dinçer, İrem

doi:10.1007/s10554-021-02235-x

Cited by 15 publications

(5 citation statements)

References 33 publications

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“…Wakami [ 19 ] showed that an increase in LVEDP is associated with a decrease in LAS r . Moreover, LAS r can accurately categorize patients based on a normal or elevated LV filling pressures [ 14 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Left atrial reservoir strain as a predictor of cardiac outcome in patients with heart failure: the HaFaC cohort study

Bouwmeester

Stam

Loon

et al. 2022

BMC Cardiovasc Disord

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Background The left atrium (LA) is a key player in the pathophysiology of systolic and diastolic heart failure (HF). Speckle tracking derived LA reservoir strain (LASr) can be used as a prognostic surrogate for elevated left ventricular filling pressure similar to NT-proBNP. The aim of the study is to investigate the correlation between LASr and NT-proBNP and its prognostic value with regards to the composite endpoint of HF hospitalization and all-cause mortality within 1 year. Methods Outpatients, sent to the echocardiography core lab because of HF, were enrolled into this study. Patients underwent a transthoracic echocardiographic examination, commercially available software was used to measure LASr. Blood samples were collected directly after the echocardiographic examination to determine NT-proBNP. Results We included 174 HF patients, 43% with reduced, 36% with mildly reduced, and 21% with preserved ejection fraction. The study population showed a strong inverse correlation between LASr and log-transformed NT-proBNP (r = − 0.75, p < 0.01). Compared to NT-proBNP, LASr predicts the endpoint with a comparable specificity (83% vs. 84%), however with a lower sensitivity (70% vs. 61%). Conclusion LASr is inversely correlated with NT-proBNP and a good echocardiographic predictor for the composite endpoint of hospitalization and all-cause mortality in patients with HF. Trial registration:https://www.trialregister.nl/trial/7268

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Section: Discussionmentioning

confidence: 99%

Left atrial reservoir strain as a predictor of cardiac outcome in patients with heart failure: the HaFaC cohort study

Bouwmeester

Stam

Loon

et al. 2022

BMC Cardiovasc Disord

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“…(23) STE, however, has the distinct advantage of almost 2 decades of research and its clinical use is supported by treatment guidelines. (24) Peak atrial longitudinal strain (PALS) of the left atrium (LA) is increasingly used to assess atrial reservoir function and mirrors elevation in LA filling pressures, (25) serving as a sensitive tool to assess early cardiac dysfunction. Relatively few studies on this topic have been carried out, but there is emerging evidence to suggest its utility in the diagnosis of subclinical HIV-associated cardiovascular disease.…”

Section: Remodelling In Hiv-infectionmentioning

confidence: 99%

Subclinical cardiovascular remodelling in HIV-infection: a multimodal descriptive study of two serodiscordant, monozygotic twins

Robbertse,

Steyn,

Rajah

et al. 2024

SAHJ

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Cardiovascular abnormalities have been demonstrated in people living with HIV at the time of HIV diagnosis, but pathology may be challenging to diagnose in the individual. To describe subtle cardiovascular remodelling and dysfunction in two identical twins, one without HIV and the other with a new diagnosis of HIV (serodiscordant). We hypothesise that a difference in cardiovascular parameters would not be demonstrable between the twins, unless non-genetic (environmental) factors were influencing the cardiovascular system. Significant cardiovascular differences likely represent occult pathology secondary to the effects of early HIV-infection, before the initiation of antiretroviral therapy. A 25-year-old female, incidentally diagnosed with HIV (CD4 count 513 cells/ml; estimated time of HIV infection 7-months), underwent cardiovascular magnetic resonance imaging, cardiac biomarker evaluation, and echocardiographic strain assessment. Her healthy, HIV-uninfected identical twin, living together since birth, underwent an identical assessment for comparison. Blinded measurements were performed.

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“…LASr is now proposed as part of the algorithm used for the assessment of left ventricular filling pressures [ 8 , 13 ]. It is also considered as a prognostic biomarker, especially in atrial fibrillation where it indicates the probability of success of an external electric shock, and it is a predictive factor for stroke [ 12 , 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Coronary microvascular dysfunction and atrial reservoir function

Mela,

Riou,

Barone-Rochette

2024

Cardiovasc Ultrasound

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Background Coronary microvascular dysfunction (CMD) refers to structural and functional abnormalities of the coronary microcirculation, which may be diagnosed using invasive coronary physiology. CMD is responsible for impaired diastolic cardiac function. It has recently been suggested that left atrial strain (LASr) represents a highly sensitive tool for detecting cardiac diastolic function abnormalities. Accordingly, the aim of this study was to investigate the relationship between CMD and LASr. Methods Consecutively enrolled patients with non-obstructed coronary arteries (NOCA) underwent CMD and LASr evaluation by invasive thermodilution and noninvasive echocardiography, respectively. Results Forty-two (42) patients were included, out of which 26 presented with CMD. There were no significant differences between CMD-positive and negative patients in terms of clinical and echocardiographic characteristics. LASr was significantly reduced in patients with CMD (24.6% ± 6.1 vs. 30.3 ± 7.8%, p = 0.01). A moderate correlation was observed between coronary flow reserve and LAsr (r = 0.47, p = 0.002). A multivariate logistic regression analysis demonstrated that CMD was independently associated with LASr (OR = 0.88, 95%CI 0.78–0.99.135, p = 0.04). A LASr cut-off of 25.5% enabled an optimal classification of patients with or without CMD. Conclusion Patients with NOCA and CMD had a significantly reduced LASr compared with patients without CMD, suggesting the early impairment of diastolic function in these patients.

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LA reservoir strain: a sensitive parameter for estimating LV filling pressure in patients with preserved EF

Cited by 15 publications

References 33 publications

Left atrial reservoir strain as a predictor of cardiac outcome in patients with heart failure: the HaFaC cohort study

Left atrial reservoir strain as a predictor of cardiac outcome in patients with heart failure: the HaFaC cohort study

Subclinical cardiovascular remodelling in HIV-infection: a multimodal descriptive study of two serodiscordant, monozygotic twins

Coronary microvascular dysfunction and atrial reservoir function

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