La respuesta monofásica a la sobrecarga oral de glucosa como factor predictivo del riesgo de diabetes tipo 2 en pacientes pediátricos con obesidad

Herrera‐Martínez, Aura D.; Enes, Patricia; Martín-Frías, Maria; Roldán, Belén; Yelmo, Rosa; Barrio, Raquel

doi:10.1016/j.anpedi.2017.01.009

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Potential perceived limitations would be that we have no anthropometric data, such as body mass index (BMI) and waist circumference, which could have an influence on glycemic status. But previous research showed that the OGTT response curve shape remained strongly associated with insulin sensitivity and β-cell function after adjusting for BMI, blood pressure, and waist circumference [6, 8]. In addition, our research follows the standard methods used in China.…”

Section: Discussionmentioning

confidence: 99%

The shape of the glucose response curve during an oral glucose tolerance test heralds β–cell function in a large Chinese population

Cheng

Yang

et al. 2019

BMC Endocr Disord

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BackgroundThe shape of the glucose response curve during an oral glucose tolerance test (OGTT) can predict β-cell function and insulin resistance. However, there have been few studies conducted on Chinese people. Thus, we aimed to verify the usefulness of the glucose response curve in a large Chinese population.MethodsA total of 9059 OGTT (3-h tests) were categorized into either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, the Matsuda Index, the insulinogenic index, and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT.ResultsThe shape of the OGTT glucose response curve was monophasic in 87.3% and multiphasic in 12.7% of participants. Individuals in the multiphasic group were younger compared to those in the monophasic group (38.6 ± 13.6 vs. 35.4 ± 13.5, P < 0.001). Individuals in the monophasic group had significantly higher fasting plasma glucose (FPG 5.6 ± 13.5 vs. 5.2 ± 0.6, P < 0.001), fasting insulin (FINS 14.8 ± 8.7 vs. 13.5 ± 7.9, P < 0.01), and homeostasis model assessment of insulin resistance (HOMA-IR 3.8 ± 2.6 vs. 3.1 ± 2.0, P < 0.001) and impaired β-cell function (disposition index 12.7 ± 14.1 vs. 16.6 ± 17.8, P < 0.001) compared to those in the multiphasic group.ConclusionThe monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.

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Section: Discussionmentioning

confidence: 99%

The shape of the glucose response curve during an oral glucose tolerance test heralds β–cell function in a large Chinese population

Cheng

Yang

et al. 2019

BMC Endocr Disord

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Oral Glucose Tolerance Test in Patients with Cystic Fibrosis Compared to the Overweight and Obese: A Different Approach in Understanding the Results

et al. 2022

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(1) Background: In cystic fibrosis (CF), the oral glucose tolerance test (OGTT) is recommended from 10 years old annually to screen and diagnose cystic fibrosis-related diabetes (CFRD). Alternative OGTT characteristics (glucose curve shape, time to glucose peak, one-hour glucose value, and three-hour glucose value with the new shape curve) were studied in other populations considered at high risk for diabetes; (2) Methods: The study analyses classical and alternative OGGT characteristics from 44 children (22 CF, 22 obese without CF), mean age: 12.9 ± 2.2 years evaluated in a single-center from Romania. (3) Results: In 59.1% of children with CF, the predominant OGTT pattern was: abnormal glucose metabolism or CFRD, with a monophasic curve shape, a late peak glucose level, and 1 h glucose ≥ 155 mg/dL, showing a very different pattern compared with sex and age-matched obese children. Statistical estimation agreement between the late glucose peak (K = 0.60; p = 0.005), the 1 h glucose ≥ 155 mg/dL during OGTT (K = 0.69, p = 0.001), and the classical method of interpretation was found. (4) Conclusions: Late peak glucose and 1 h glucose level ≥ 155 mg/dL during OGTT can be used for diagnosing the early glucose metabolism alteration in children with CF.

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La respuesta monofásica a la sobrecarga oral de glucosa como factor predictivo del riesgo de diabetes tipo 2 en pacientes pediátricos con obesidad

Cited by 2 publications

References 20 publications

The shape of the glucose response curve during an oral glucose tolerance test heralds β–cell function in a large Chinese population

The shape of the glucose response curve during an oral glucose tolerance test heralds β–cell function in a large Chinese population

Oral Glucose Tolerance Test in Patients with Cystic Fibrosis Compared to the Overweight and Obese: A Different Approach in Understanding the Results

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