La rétinopathie radique : données actuelles et perspectives

Purpose of the Review. In this review, we bring together recent developments in the detection and management of radiation retinopathy. Recent Findings Research into OCT-angiography for radiation retinopathy has led to the identification of biomarkers of early radiation-induced changes in the retinal microvasculature including focal capillary loss and vascular remodeling. These microvasculature changes are detectable after exposure to radiation but prior to the emergence of classical clinical markers historically used to diagnose radiation retinopathy. The ability to detect subclinical changes may present the need to redefine radiation retinopathy diagnostic criteria which may ultimately impact management. Additionally, explorations into prophylactic treatment following radiation exposure and development of newer anti-VEGF agents may present more options for retinal specialists to prevent or treat vision loss and retinal vasculopathy from radiation exposure. Summary Currently, anti-VEGF injections and/or intravitreal steroids remain the primary treatment following a diagnosis of radiation retinopathy. However, a mainstay treatment and management strategy have not yet been identified. In the future, new anatomical endpoints for radiation retinopathy may be identified with OCT-angiography while prophylactic treatment with anti-VEGF agents following radiation therapy may reduce initial vision loss and changes to the retina.

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Radiation Retinopathy

Chen

Browne

2023

Curr Ophthalmol Rep

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Efficacy of Intravitreal Injections Anti-Vascular Endothelial Growth Factor Treatment for Radiation Retinopathy: A Systematic Review and Meta-analysis

Zhuang,

Yang,

Liao

et al. 2024

American Journal of Ophthalmology

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Assessment of gaze direction during head and neck irradiation and dosimetric impact on the retina, macula and papilla in a cohort of 240 patients with paraoptic tumors

Azemar,

Fontbonne,

Claude Quintyn

et al. 2024

Radiotherapy and Oncology

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La rétinopathie radique : données actuelles et perspectives

Cited by 3 publications

References 48 publications

Radiation Retinopathy

Radiation Retinopathy

Efficacy of Intravitreal Injections Anti-Vascular Endothelial Growth Factor Treatment for Radiation Retinopathy: A Systematic Review and Meta-analysis

Assessment of gaze direction during head and neck irradiation and dosimetric impact on the retina, macula and papilla in a cohort of 240 patients with paraoptic tumors

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