Based on retrospective analysis of 212 cases diagnosed and treated at the King Khalid University Hospital in Riyadh over a period of 5 years, this study is the first attempt to provide preliminary data on intracranial space-occupying lesions in Saudi Arabia. There were 184 (87%) neoplasms and 28 (13%) nonneoplastic tumors, mostly inflammatory masses. Age and sex distribution was comparable with that reported from other studies. Neuroepithelial tumors comprised 39.7% of all intracranial neoplasms, followed by meningiomas (22.8%), pituitary adenomas (16.8%), metastatic tumors (8.2%), malformative tumors (4.3%), and neurinomas (3.8%). Males were generally more affected than females. Tuberculomas constituted about 5% of all intracranial space-occupying lesions and, therefore, should always be considered in the differential diagnosis.