2020
DOI: 10.1051/medsci/2020172
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La saga de l’induction neurale : presque un siècle de recherche

Abstract: La formation du système nerveux débute par l’induction neurale, un processus qui permet aux cellules de l’ectoderme (tissu cible) d’acquérir un destin neural en réponse à des signaux provenant du mésoderme dorsal (tissu inducteur). Ce processus, décrit en 1924 sur l’amphibien, n’a reçu une explication moléculaire qu’au milieu des années 1990. Pendant cette période, plusieurs auteurs se sont intéressés au rôle joué par la membrane du tissu cible mais peu de travaux décisifs ont décrit la transduction du signal … Show more

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Cited by 2 publications
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“…Embryonic neural induction is a pivotal stage in the formation of the entire nervous system. This process involves the transformation of primitive ectodermal cells through the action of distinct signalling and regulatory factors, resulting in their differentiation into neuroectodermal cells [ [1] , [2] , [3] , [4] , [5] ]. As a result, neural stem cells establish the neuroepithelium of the neural plate and neural tube, giving rise to diverse cell types.…”
Section: Introductionmentioning
confidence: 99%
“…Embryonic neural induction is a pivotal stage in the formation of the entire nervous system. This process involves the transformation of primitive ectodermal cells through the action of distinct signalling and regulatory factors, resulting in their differentiation into neuroectodermal cells [ [1] , [2] , [3] , [4] , [5] ]. As a result, neural stem cells establish the neuroepithelium of the neural plate and neural tube, giving rise to diverse cell types.…”
Section: Introductionmentioning
confidence: 99%