La sarcopénie est-elle un facteur de morbi-mortalité dans le traitement des tumeurs localisées de la vessie infiltrant le muscle ?

Fraisse, G; Renard, Yohann; Lebâcle, C.; Masson-Lecomte, A.; Desgrandchamps, François; Hennequin, C.; Bessede, T.; Irani, Jacques

doi:10.1016/j.purol.2019.11.002

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…Indeed, in line with our results, Stangl-Kremser et al have highlighted how sarcopenia is not prognostic of survival in patients unfit for radical cystectomy or systemic chemotherapy (29). Furthermore in the comparison between sarcopenic (n=67) and non-sarcopenic (n=79) patients by Fraisse et al sarcopenia was associated with neither survival nor severity of radiation-related adverse events (30).…”

Section: Discussionsupporting

confidence: 84%

Curative Radiotherapy in Elderly Patients With Muscle Invasive Bladder Cancer: The Prognostic Role of Sarcopenia

Ferini¹,

Cacciola

Parisi³

et al. 2021

In Vivo

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Background/Aim: To evaluate the impact of sarcopenia in muscle invasive bladder cancer (MIBC) elderly patients submitted to curative radiotherapy. Patients and Methods: Patients received radiotherapy between 2013 and 2018, and the skeletal muscle index was calculated to classify them as sarcopenic or non-sarcopenic. Primary endpoints were overall survival (OS), cancer specific survival (CSS), 90-day mortality and toxicity. Results: A total of 28 patients with a median age of 85 years met our inclusion criteria and 8 of them were sarcopenic. With a median prescribed dose of 61 Gy and a median follow-up of 24.5 months, OS rates in the sarcopenic and non-sarcopenic groups were 100% and

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Section: Discussionsupporting

confidence: 84%

Curative Radiotherapy in Elderly Patients With Muscle Invasive Bladder Cancer: The Prognostic Role of Sarcopenia

Ferini¹,

Cacciola

Parisi³

et al. 2021

In Vivo

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“…Ultimately, our meta-analysis comprised 21 studies, as depicted in Figure 1. 20–40 Specific details of the included studies are presented in Table 1. The majority of studies (n = 19) had a retrospective design, while two studies had a prospective design.…”

Section: Resultsmentioning

confidence: 99%

Impact of sarcopenia on outcomes of bladder cancer undergoing radical cystectomy: A systematic review and meta-analysis

Qin,

2024

Scott Med J

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Objective To provide synthesized evidence on the association between sarcopenia and risk of mortality, recurrence and postoperative complications in patients with bladder cancer and undergoing radical cystectomy (RC). Methods Only studies with observational design that investigated the association between sarcopenia and outcomes of interest among patients with bladder cancer undergoing RC were included. The outcomes of interest were mortality, recurrence, and postoperative complications. The systematic search was conducted using three large databases, that is, PubMed, EMBASE, and Scopus. A random effects model was used for the analysis and pooled effect sizes were reported as odds ratio (OR) or hazards ratio (HR) along with 95% confidence intervals (CIs). Results A total of 21 studies with 4997 patients were included. Compared to non-sarcopenic subjects, those with sarcopenia had increased risk of all-cause mortality (HR 1.45, 95% CI: 1.32, 1.61), cancer-specific mortality (HR 1.74, 95% CI: 1.49, 2.03) and a lower recurrence free survival (HR 1.84, 95% CI: 1.30, 2.62). Patients with sarcopenia also had higher risk of developing complications within 90 days postoperatively (OR 1.77, 95% CI: 1.23, 2.55). Conclusion Sarcopenia among patients with bladder cancer and managed using RC is associated with adverse survival outcomes and an increased risk of postoperative complications.

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Sarcopenia predicts prognosis of bladder cancer patients after radical cystectomy: A study based on the Chinese population

Mao

Wang

et al. 2020

Clinical & Translational Med

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La sarcopénie est-elle un facteur de morbi-mortalité dans le traitement des tumeurs localisées de la vessie infiltrant le muscle ?

Cited by 8 publications

References 20 publications

Curative Radiotherapy in Elderly Patients With Muscle Invasive Bladder Cancer: The Prognostic Role of Sarcopenia

Curative Radiotherapy in Elderly Patients With Muscle Invasive Bladder Cancer: The Prognostic Role of Sarcopenia

Impact of sarcopenia on outcomes of bladder cancer undergoing radical cystectomy: A systematic review and meta-analysis

Sarcopenia predicts prognosis of bladder cancer patients after radical cystectomy: A study based on the Chinese population

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