La sclérose latérale amyotrophique : une maladie neurodégénérative emblématique

Viader, Fausto

doi:10.1016/j.banm.2023.01.002

Bulletin de l'Académie Nationale de Médecine

2023

DOI: 10.1016/j.banm.2023.01.002

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La sclérose latérale amyotrophique : une maladie neurodégénérative emblématique

Fausto Viader

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2023

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Cited by 2 publications

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Amyotrophic Lateral Sclerosis Involving Gliopathy

Haj-Khlifa,

El Ghachi,

Oukhrib

et al. 2023

Physiology and Function of Glial Cells in Health and Disease

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Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease, causing death within two to five years following diagnosis. ALS is a disease characterized by motor neuron degeneration and destruction of the neuromuscular junction (NMJ). To date, numerous genetic mutations have been associated with ALS, but the mutation in the gene coding for superoxide dismutase (SOD1) has been the most extensively studied. Nevertheless, studies carried out on rodent models and ALS patients have shown that damage to glial cells contributes directly to the development and progression of the disease. However, few studies have focused on the properties of glial cells in ALS. The accumulation of knowledge on the active role and pathological mechanisms of each glial type in the disease must be carefully applied to better understand the ALS pathophysiology, but also for the development of targeted therapy for glial cells. Therefore, in this chapter the authors aimed to compile the most recent information on how each type of glial cell contributes to the development of ALS.

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Amyotrophic Lateral Sclerosis Involving Gliopathy

Haj-Khlifa,

El Ghachi,

Oukhrib

et al. 2023

Physiology and Function of Glial Cells in Health and Disease

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Investigation of Potential Neuroprotective Role of Chitosan-Based Biomaterials and Their Derivatives by Targeting Glial Cells

Hamdan,

Rhazi,

Kabdy

et al. 2023

Physiology and Function of Glial Cells in Health and Disease

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Glial cells, although often overlooked in comparison with neurons, play a crucial role in the structure and function of the nervous system. Their loss can lead to impairment of functions such as learning and memory, contributing to neurodegenerative diseases. To combat these diseases effectively, therapeutic strategies must restore the function of neuronal and glial cells. Natural resources offer promising therapeutic molecules for the treatment of neurodegenerative diseases. Chitosan (CTS), chitooligosaccharide (COS) and their derivatives from arthropod exoskeletons have attracted the attention of neuroscientists because of their neuroprotective effects and their ability to transport therapeutic substances across the blood-brain barrier (BBB). This chapter explores the role of natural resources in the fight against neuronal diseases.

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La sclérose latérale amyotrophique : une maladie neurodégénérative emblématique

Cited by 2 publications

References 118 publications

Amyotrophic Lateral Sclerosis Involving Gliopathy

Amyotrophic Lateral Sclerosis Involving Gliopathy

Investigation of Potential Neuroprotective Role of Chitosan-Based Biomaterials and Their Derivatives by Targeting Glial Cells

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