La stimulation transcrânienne à courant continu (tDCS) dans la dépression : bilan de près d’une décennie de recherche clinique

Palm, Ulrich; Ayache, Samar S.; Padberg, Frank; Lefaucheur, Jean‐Pascal

doi:10.1016/j.encep.2015.06.003

Cited by 14 publications

(3 citation statements)

References 55 publications

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“…Since DCS and LFS are two promising neurostimulation methods for the modulation of learning and memory 98 , we sought to test the combination of the two protocols on MEA neural cell co-cultures. Surprisingly, in control condition combining DCS and LFS resulted in down-regulation of BDNF and an up-regulation of NR2B expression, which was supported by no significant change in network synchrony or excitability (one-way ANOVA, p > 0.05; Supplementary Fig.…”

Section: Discussionmentioning

confidence: 99%

Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro

Latchoumane

Jackson

Sendi

et al. 2018

Sci Rep

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Functional electrical stimulation (FES) is rapidly gaining traction as a therapeutic tool for mediating the repair and recovery of the injured central nervous system (CNS). However, the underlying mechanisms and impact of these stimulation paradigms at a molecular, cellular and network level remain largely unknown. In this study, we used embryonic stem cell (ESC)-derived neuron and glial co-cultures to investigate network maturation following acute administration of L-glutamate, which is a known mediator of excitotoxicity following CNS injury. We then modulated network maturation using chronic low frequency stimulation (LFS) and direct current stimulation (DCS) protocols. We demonstrated that L-glutamate impaired the rate of maturation of ESC-derived neurons and glia immediately and over a week following acute treatment. The administration of chronic LFS and DCS protocols individually following L-glutamate infusion significantly promoted the excitability of neurons as well as network synchrony, while the combination of LFS/DCS did not. qRT-PCR analysis revealed that LFS and DCS alone significantly up-regulated the expression of excitability and plasticity-related transcripts encoding N-methyl-D-aspartate (NMDA) receptor subunit (NR2A), brain-derived neurotrophic factor (BDNF) and Ras-related protein (RAB3A). In contrast, the simultaneous administration of LFS/DCS down-regulated BDNF and RAB3A expression. Our results demonstrate that LFS and DCS stimulation can modulate network maturation excitability and synchrony following the acute administration of an inhibitory dose of L-glutamate, and upregulate NR2A, BDNF and RAB3A gene expression. Our study also provides a novel framework for investigating the effects of electrical stimulation on neuronal responses and network formation and repair after traumatic brain injury.

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Section: Discussionmentioning

confidence: 99%

Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro

Latchoumane

Jackson

Sendi

et al. 2018

Sci Rep

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“…Although tDCS is usually applied in treating depression [ 204 ], its effect on PSD has not been fully illustrated. Valiengo et al [ 205 ] first demonstrated that tDCS can improve Hamilton Depression Rating Scale scores in patients with PSD through a randomized controlled trial.…”

Section: Overview Of Neuromodulation and Nibsmentioning

confidence: 99%

Noninvasive Brain Stimulation for Neurorehabilitation in Post-Stroke Patients

Zhou

et al. 2023

Brain Sciences

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Characterized by high morbidity, mortality, and disability, stroke usually causes symptoms of cerebral hypoxia due to a sudden blockage or rupture of brain vessels, and it seriously threatens human life and health. Rehabilitation is the essential treatment for post-stroke patients suffering from functional impairments, through which hemiparesis, aphasia, dysphagia, unilateral neglect, depression, and cognitive dysfunction can be restored to various degrees. Noninvasive brain stimulation (NIBS) is a popular neuromodulatory technology of rehabilitation focusing on the local cerebral cortex, which can improve clinical functions by regulating the excitability of corresponding neurons. Increasing evidence has been obtained from the clinical application of NIBS, especially repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). However, without a standardized protocol, existing studies on NIBS show a wide variation in terms of stimulation site, frequency, intensity, dosage, and other parameters. Its application for neurorehabilitation in post-stroke patients is still limited. With advances in neuronavigation technologies, functional near-infrared spectroscopy, and functional MRI, specific brain regions can be precisely located for stimulation. On the basis of our further understanding on neural circuits, neuromodulation in post-stroke rehabilitation has also evolved from single-target stimulation to co-stimulation of two or more targets, even circuits and the network. The present study aims to review the findings of current research, discuss future directions of NIBS application, and finally promote the use of NIBS in post-stroke rehabilitation.

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“…This therapy has almost no side effects and is well tolerated among all treatment groups. Stimulation of cortical regions may result in changes in membrane resting potentials and modify synaptic transmission in the DLPFC, which ultimately results in a significant, but only moderate, reduction of depression (Liebetanz et al, 2006 ; Palm et al, 2016a ).…”

Section: Adjunctive Biological Options For Treating Trd Alongside Antmentioning

confidence: 99%

Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use

et al. 2018

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In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies.

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La stimulation transcrânienne à courant continu (tDCS) dans la dépression : bilan de près d’une décennie de recherche clinique

Cited by 14 publications

References 55 publications

Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro

Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro

Noninvasive Brain Stimulation for Neurorehabilitation in Post-Stroke Patients

Vagus Nerve Stimulation (VNS) and Other Augmentation Strategies for Therapy-Resistant Depression (TRD): Review of the Evidence and Clinical Advice for Use

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