Historic centers have suffered different processes of neglect, occupation, segregation, gentrification, and touristification as a result of changes in demand and policies. Currently, they are going through a homogenization process motivated by tourist pressure, which is causing the expulsion of the local population; this is a common topic of interest for media and political agendas, which requires scientific analysis. This research aims at identifying the winning and the losing tourist groups in the historic center of Seville. It is structured in two parts: a conceptual one based on the bibliographic review with which one wants to know how the current society responds to tourist pressure through defining and characterizing the processes of substitution of uses and inhabitants, and another empirical one in which the analysis of statistical indicators (demographic, economic, and residential) treated with Geographic Information System (GIS) allows us to measure the degree of existing vulnerability and analyze social and spatial effects caused by the tourism in Seville.