Lab-on-a-Chip for Cardiovascular Physiology and Pathology

Beverung, Sean; Wu, Jingwen; Steward, Robert L.

doi:10.3390/mi11100898

Cited by 15 publications

(10 citation statements)

References 119 publications

(191 reference statements)

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“…Lab-on-a-chip (LoC) technology has a high potential to address these needs. There has been significant interest in development of advanced LoC devices during recent years [8][9][10] . However, achieving a market-ready device still requires crucial improvements of its performance.…”

Section: Introductionmentioning

confidence: 99%

An integrated platform for metamaterial-based sensing and surface acoustic wave-based acoustofluidics utilising circular interdigital transducers

et al. 2022

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Section: Introductionmentioning

confidence: 99%

An integrated platform for metamaterial-based sensing and surface acoustic wave-based acoustofluidics utilising circular interdigital transducers

et al. 2022

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“…As this review focuses on systems which directly apply mechanical stimulation, this system is not discussed here. For further review of recent developments in heart-on-a-chip models please see ( Beverung et al, 2020 ).…”

Section: Incorporation Of Biomechanical Cues In Ooc Models For Differmentioning

confidence: 99%

Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models

Thompson

Knight

et al. 2020

Front. Bioeng. Biotechnol.

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Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and disease hold great promise for improving fundamental research, drug development, personalized medicine, and testing of pharmaceuticals, food substances, pollutants etc. Cells within the body are exposed to biomechanical stimuli, the nature of which is tissue specific and may change with disease or injury. These biomechanical stimuli regulate cell behavior and can amplify, annul, or even reverse the response to a given biochemical cue or drug candidate. As such, the application of an appropriate physiological or pathological biomechanical environment is essential for the successful recapitulation of in vivo behavior in OOC models. Here we review the current range of commercially available OOC platforms which incorporate active biomechanical stimulation. We highlight recent findings demonstrating the importance of including mechanical stimuli in models used for drug development and outline emerging factors which regulate the cellular response to the biomechanical environment. We explore the incorporation of mechanical stimuli in different organ models and identify areas where further research and development is required. Challenges associated with the integration of mechanics alongside other OOC requirements including scaling to increase throughput and diagnostic imaging are discussed. In summary, compelling evidence demonstrates that the incorporation of biomechanical stimuli in these OOC or microphysiological systems is key to fully replicating in vivo physiology in health and disease.

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“…The conventional fabrication techniques of OOCs include photolithography, soft lithography, [89][90][91] replica molding, [92] capillary molding, [89] microcontact printing, [92] microtransfer molding, [89] and injection molding. [93][94][95] One of the limitations of the above methods is the limited fabrication capability for forming the complex structures of organs and tissues.…”

Section: Bioprintingmentioning

confidence: 99%

3D bioprinted organ‐on‐chips

et al. 2022

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Organ-on-a-chip (OOC) platforms recapitulate human in vivo-like conditions more realistically compared to many animal models and conventional two-dimensional cell cultures. OOC setups benefit from continuous perfusion of cell cultures through microfluidic channels, which promotes cell viability and activities. Moreover, microfluidic chips allow the integration of biosensors for real-time monitoring and analysis of cell interactions and responses to administered drugs. Three-dimensional (3D) bioprinting enables the fabrication of multicell OOC platforms with sophisticated 3D structures that more closely mimic human tissues. 3D-bioprinted OOC platforms are promising tools for understanding the functions of organs, disruptive influences of diseases on organ functionality, and screening the efficacy as well as toxicity of drugs on organs. Here, common 3D bioprinting techniques, advantages, and limitations of each method are reviewed. Additionally, recent advances, applications, and potentials of 3D-bioprinted OOC platforms for emulating various human organs are presented. Last, current challenges and future perspectives of OOC platforms are discussed. K E Y W O R D S biomaterials, bioprinting, disease-on-a-chip, microfluidics, organ-on-a-chip 1 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Lab-on-a-Chip for Cardiovascular Physiology and Pathology

Cited by 15 publications

References 119 publications

An integrated platform for metamaterial-based sensing and surface acoustic wave-based acoustofluidics utilising circular interdigital transducers

An integrated platform for metamaterial-based sensing and surface acoustic wave-based acoustofluidics utilising circular interdigital transducers

Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models

3D bioprinted organ‐on‐chips

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