Lab-on-a-chip (lab-on-a-phone) for analysis of blood and diagnosis of blood diseases

Akther, Fahima; Tran, Huong; Zhang, Jun; Nguyen, Nam‐Trung; Ta, Hang T.

doi:10.1016/b978-0-12-823971-1.00009-x

Cited by 5 publications

(3 citation statements)

References 73 publications

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“…The blood clotting cascade is a set of actions in response to bleeding or association brought on by tissue damage or contact with artificial surfaces. [12][13][14][15][16][17] Each action leads to the next, which ultimately causes the formation of a blood clot (thrombosis). Thrombosis within a blood vessel can result in fatal clinical conditions such as heart attack, stroke, pulmonary embolism, etc.…”

Section: Coagulation Cascadementioning

confidence: 99%

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

Luu,

Nguyen,

2023

Adv Healthcare Materials

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The use of biomaterials in implanted medical devices remains hampered by platelet adhesion and blood coagulation. Thrombus formation is a prevalent cause of failure of these blood‐contacting devices. Although systemic anticoagulant can be used to support materials and devices with poor blood compatibility, its negative effects such as an increased chance of bleeding, make materials with superior hemocompatibility extremely attractive, especially for long‐term applications. This review examines blood–surface interactions, the pathogenesis of clotting on blood‐contacting medical devices, popular surface modification techniques, mechanisms of action of anticoagulant coatings, and discusses future directions in biomaterial research for preventing thrombosis. In addition, this paper comprehensively reviews several novel methods that either entirely prevent interaction between material surfaces and blood components or regulate the reaction of the coagulation cascade, thrombocytes, and leukocytes.This article is protected by copyright. All rights reserved

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Section: Coagulation Cascadementioning

confidence: 99%

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

Luu,

Nguyen,

2023

Adv Healthcare Materials

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“…In the current framework, these psychological and social factors are only accessible through patient-reported questionnaire data. However, monitoring of stress-related biomarkers using lab-on-a-chip remote technology is possible 26 and could provide an important and currently neglected biological perspective on patient state for integration into the digital twin.…”

Section: Limitations Of Digital Twin Frameworkmentioning

confidence: 99%

A Digital Twin Framework for Precision Neuromusculoskeletal Health Care: Extension Upon Industrial Standards

Saxby,

Pizzolato,

Diamond

2023

Journal of Applied Biomechanics

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There is a powerful global trend toward deeper integration of digital twins into modern life driven by Industry 4.0 and 5.0. Defense, agriculture, engineering, manufacturing, and urban planning sectors have thoroughly incorporated digital twins to great benefit across their respective product lifecycles. Despite clear benefits, a digital twin framework for health and medical sectors is yet to emerge. This paper proposes a digital twin framework for precision neuromusculoskeletal health care. We build upon the International Standards Organization framework for digital twins for manufacturing by presenting best available computational models within a digital twin framework for clinical application. We map a use case for modeling Achilles tendon mechanobiology, highlighting how current modeling practices align with our proposed digital twin framework. Similarly, we map a use case for advanced neurorehabilitation technology, highlighting the role of a digital twin in control of systems where human and machine are interfaced. Future work must now focus on creating an informatic representation to govern how digital data are passed to, from, and within the digital twin, as well as specific standards to declare which measurement systems and modeling methods are acceptable to move toward widespread use of the digital twin framework for precision neuromusculoskeletal health care.

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“…As stated above, LOC devices have been used in various fields, such as chemistry, drug production, medicine, proteomics, and food safety, and their usage has only been expanding during the past few years [ 17 , 18 , 19 , 20 ]. In developing countries, their application in the healthcare field can be characterized as urgent and inevitable, with over 1 billion people lacking basic health care services [ 4 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review

2023

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Food quality and safety are important to protect consumers from foodborne illnesses. Currently, laboratory scale analysis, which takes several days to complete, is the main way to ensure the absence of pathogenic microorganisms in a wide range of food products. However, new methods such as PCR, ELISA, or even accelerated plate culture tests have been proposed for the rapid detection of pathogens. Lab-on-chip (LOC) devices and microfluidics are miniaturized devices that can enable faster, easier, and at the point of interest analysis. Nowadays, methods such as PCR are often coupled with microfluidics, providing new LOC devices that can replace or complement the standard methods by offering highly sensitive, fast, and on-site analysis. This review’s objective is to present an overview of recent advances in LOCs used for the identification of the most prevalent foodborne and waterborne pathogens that put consumer health at risk. In particular, the paper is organized as follows: first, we discuss the main fabrication methods of microfluidics as well as the most popular materials used, and then we present recent literature examples for LOCs used for the detection of pathogenic bacteria found in water and other food samples. In the final section, we summarize our findings and also provide our point of view on the challenges and opportunities in the field.

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Lab-on-a-chip (lab-on-a-phone) for analysis of blood and diagnosis of blood diseases

Cited by 5 publications

References 73 publications

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

Unravelling Surface Modification Strategies for Preventing Medical Device‐Induced Thrombosis

A Digital Twin Framework for Precision Neuromusculoskeletal Health Care: Extension Upon Industrial Standards

Polymeric and Paper-Based Lab-on-a-Chip Devices in Food Safety: A Review

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