Lab-on-a-chip or Chip-in-a-lab: Challenges of Commercialization Lost in Translation

Mohammed, Mazher Iqbal; Haswell, Steven; Gibson, Ian

doi:10.1016/j.protcy.2015.07.010

Cited by 126 publications

(86 citation statements)

References 14 publications

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“…Using basal platform designs could enable the creation of standards in LOC‐based POCT production, which have been pointed out as a potential leverage for scaling up their commercialization . However, standardization can also be considered as a drag on innovation.…”

Section: Integrationmentioning

confidence: 99%

“…Using basal platform designs could enable the creation of standards in LOC-based POCT production, which have been pointed out as a potential leverage for scaling up their commercialization. 52 However, standardization can also be considered as a drag on innovation. Continuing research is essential and, as there is still no onesize-fits-all POCT design, using a model such as these could prevent teams from having to start from scratch and ease the creation process of integrated devices.…”

Section: Open Platformsmentioning

confidence: 99%

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Innovative technologies for point‐of‐care testing of viral hepatitis in low‐resource and decentralized settings

Duchesne

Lacombe

2017

Journal of Viral Hepatitis

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According to the Global Burden of Diseases, chronic viral hepatitis B and C are one of the most challenging global health conditions that rank among the first causes of morbidity and mortality worldwide. Low- and middle-income countries are particularly affected by the health burden associated with HBV or HCV infection. One major gap in efficiently addressing the issue of viral hepatitis is universal screening. However, the costs and chronic lack of human resources for using traditional screening strategies based on serology and molecular biology preclude any scaling-up. Point-of-care tests have been deemed a powerful potential solution to fill the current diagnostics gap in low-resource and decentralized settings. Despite high interest resulting from their development in recent years, very few point-of-care devices have reached the market. Scaling down and automating all testing steps in 1 single device (eg, sample preparation, detection and readout) is indeed challenging. But innovations in multiple disciplines such as nanotechnologies, microfluidics, biosensors and synthetic biology have led to the creation of chip-sized laboratory systems called "lab-on-a-chip" devices. This review aims to explain how these innovations can overcome technological barriers that usually arise for each testing step while developing integrated point-of-care tests. Point-of-care test prototypes rarely meet the requirements for mass production, which also hinders their large-scale production. In addition to logistical hurdles, legal and economic constraints specific to the commercialization of in vitro diagnostics, which have also participated in the low transfer of innovative point-of-care tests to the field, are discussed.

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Section: Integrationmentioning

confidence: 99%

Section: Open Platformsmentioning

confidence: 99%

Innovative technologies for point‐of‐care testing of viral hepatitis in low‐resource and decentralized settings

Duchesne

Lacombe

2017

Journal of Viral Hepatitis

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“…Plastics have become ubiquitous part of our everyday life and are found in everything from packaging, toys, micro-technology and even biomedical applications [1,2]. The prevalence of plastics is primarily due to the wide range of advantageous material properties, such as its lightweight, durability and ability to be manufacturing using a diverse range of processes.…”

Section: Introductionmentioning

confidence: 99%

A low carbon footprint approach to the reconstitution of plastics into 3D-printer filament for enhanced waste reduction

Mohammed¹,

Mohan²,

Das³

et al. 2017

KEG

Self Cite

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<p>In this study we aim to investigate recycling of waste plastics products into filaments for use in a typical FDM 3D printing system. We investigate the parameters relating to control of the filament thickness to a variety of different plastic types, which include HDPE and ABS. Following filament generation, parameters were investigated to optimise the print parameters to produce a variety of demonstration models, which test the print resolution. Results suggest that the proposed supply chain can allow for highly repeatable ABS and HDPE filament generation with a diameter of 1.74 ± 0.1mm and 1.65 ± 0.1mm respectively. Ultimately, the production of usable filaments can provide a viable means of consuming waste plastics and reducing the burden of increased landfill. </p>

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“…The field of LOC and its associated microsystem equivalent technologies (microfluidics, MEMS/NEMS, μTAS, etc.) have now come to be seen as a real multidiscipli-nary field, necessitating contributions from a variety of disciplines including biology, chemistry, software development, physics and materials science (Daw and Finkelstein 2006; Guo et al 2015a; Mohammed et al 2015). LOC devices contain microfluidic elements and added components for fluid control, processing and detection capability, with various applications ranging from point-of-care diagnostics, drug discovery, environmental monitoring, and other industrial applications (Daw and Finkelstein 2006).…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotubes in microfluidic lab-on-a-chip technology: current trends and future perspectives

Ghasemi

Amiri

Zare

et al. 2017

Microfluid Nanofluid

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Advanced nanomaterials such as carbon nano-tubes (CNTs) display unprecedented properties such as strength, electrical conductance, thermal stability, and intriguing optical properties. These properties of CNT allow construction of small microfluidic devices leading to miniaturization of analyses previously conducted on a laboratory bench. With dimensions of only millimeters to a few square centimeters, these devices are called lab-on-a-chip (LOC). A LOC device requires a multidisciplinary contribution from different fields and offers automation, portability, and high-throughput screening along with a significant reduction in reagent consumption. Today, CNT can play a vital role in many parts of a LOC such as membrane channels, sensors and channel walls. This review paper provides an overview of recent trends in the use of CNT in LOC devices and covers challenges and recent advances in the field. CNTs are also reviewed in terms of synthesis, integration techniques, functionalization and superhydrophobicity. In addition, the toxicity of these nanomaterials is reviewed as a major challenge and recent approaches addressing this issue are discussed.

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Lab-on-a-chip or Chip-in-a-lab: Challenges of Commercialization Lost in Translation

Cited by 126 publications

References 14 publications

Innovative technologies for point‐of‐care testing of viral hepatitis in low‐resource and decentralized settings

Innovative technologies for point‐of‐care testing of viral hepatitis in low‐resource and decentralized settings

A low carbon footprint approach to the reconstitution of plastics into 3D-printer filament for enhanced waste reduction

Carbon nanotubes in microfluidic lab-on-a-chip technology: current trends and future perspectives

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