Lab-on-paper for all-in-one molecular diagnostics (LAMDA) of zika, dengue, and chikungunya virus from human serum

Seok, Youngung; Batule, Bhagwan S.; Kim, Min-Gon

doi:10.1016/j.bios.2020.112400

Cited by 53 publications

(59 citation statements)

References 42 publications

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“…They integrated quenching of unincorporated amplification signal reporters (QUASR) technique with the ‘LAMP box’ to improve the signals between negative and positive by many fold ( Priye et al, 2017 ). Another LAMP-based POCT was designed using paper and microfluidic control platform against ZIKV, DENV, and chikungunya virus, combinedly ( Seok et al, 2020 ). Whole amplification process was carried out on all-in-one 3D paper chip (engineered properly to have both lateral and vertical flow) using dried reagents.…”

Section: Iomt-assisted Poc Biosensing For Infectious Diseasesmentioning

confidence: 99%

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Jain

Nehra

Kumar

et al. 2021

Biosensors and Bioelectronics

259

155

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On global scale, the current situation of pandemic is symptomatic of increased incidences of contagious diseases caused by pathogens. The faster spread of these diseases, in a moderately short timeframe, is threatening the overall population wellbeing and conceivably the economy. The inadequacy of conventional diagnostic tools in terms of time consuming and complex laboratory-based diagnosis process is a major challenge to medical care. In present era, the development of point-of-care testing (POCT) is in demand for fast detection of infectious diseases along with “on-site” results that are helpful in timely and early action for better treatment. In addition, POCT devices also play a crucial role in preventing the transmission of infectious diseases by offering real-time testing and lab quality microbial diagnosis within minutes. Timely diagnosis and further treatment optimization facilitate the containment of outbreaks of infectious diseases. Presently, efforts are being made to support such POCT by the technological development in the field of internet of medical things (IoMT). The IoMT offers wireless-based operation and connectivity of POCT devices with health expert and medical centre. In this review, the recently developed POC diagnostics integrated or future possibilities of integration with IoMT are discussed with focus on emerging and re-emerging infectious diseases like malaria, dengue fever, influenza A (H1N1), human papilloma virus (HPV), Ebola virus disease (EVD), Zika virus (ZIKV), and coronavirus (COVID-19). The IoMT-assisted POCT systems are capable enough to fill the gap between bioinformatics generation, big rapid analytics, and clinical validation. An optimized IoMT-assisted POCT will be useful in understanding the diseases progression, treatment decision, and evaluation of efficacy of prescribed therapy.

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Section: Iomt-assisted Poc Biosensing For Infectious Diseasesmentioning

confidence: 99%

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Jain

Nehra

Kumar

et al. 2021

Biosensors and Bioelectronics

259

155

View full text Add to dashboard Cite

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“…The simple 2D paper based stacking device is assembled in such a way that ensures a separate flow path for saliva and reagents. On the other hand, a 3D vertical and lateral flow lab-on-paper device has been developed to target multiple viruses, including ZIKV, DENV, and chikungunya virus (Figure 7C) [191]. This device accommodates the whole LAMP-based NAT process from the dried reagents by completing serum treatment, automated flow control, and finally, the RNA amplification.…”

Section: Microfluidics-based Sensing Technologiesmentioning

confidence: 99%

Section: Microfluidics-based Sensing Technologiesmentioning

confidence: 99%

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Dengue Detection: Advances in Diagnostic Tools from Conventional Technology to Point of Care

et al. 2021

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The dengue virus (DENV) is a vector-borne flavivirus that infects around 390 million individuals each year with 2.5 billion being in danger. Having access to testing is paramount in preventing future infections and receiving adequate treatment. Currently, there are numerous conventional methods for DENV testing, such as NS1 based antigen testing, IgM/IgG antibody testing, and Polymerase Chain Reaction (PCR). In addition, novel methods are emerging that can cut both cost and time. Such methods can be effective in rural and low-income areas throughout the world. In this paper, we discuss the structural evolution of the virus followed by a comprehensive review of current dengue detection strategies and methods that are being developed or commercialized. We also discuss the state of art biosensing technologies, evaluated their performance and outline strategies to address challenges posed by the disease. Further, we outline future guidelines for the improved usage of diagnostic tools during recurrence or future outbreaks of DENV.

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“…Seak et al developed a lab-on-paper for all-in-one molecular diagnostics (LAMDA) of zika, dengue, and chikungunya virus from human serum ( Fig. 4 A) [ 151 ]. The 3D-PAD was designed by integrating lateral and vertical flows.…”

Section: Recent Applications Of Paper-based Analytical Devices For Virus Detectionmentioning

confidence: 99%

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Özer

Henry

2021

TrAC Trends in Analytical Chemistry

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The importance of user-friendly, inexpensive, sensitive, and selective detection of viruses has been highlighted again due to the recent Coronavirus disease 2019 (COVID-19) pandemic. Among the analytical tools, paper-based devices (PADs) have become a leading alternative for point-of-care (POC) testing. In this review, we discuss the recent development strategies and applications in nucleic acid-based, antibody/antigen-based and other affinity-based PADs using optical and electrochemical detection methods for sensing viruses. In addition, advantages and drawbacks of presented PADs are identified. Current state and insights towards future perspectives are presented regarding developing POC diagnosis platform for COVID-19. This review considers state-of-the-art technologies for further development and improvement in PADs performance for virus detection.

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Lab-on-paper for all-in-one molecular diagnostics (LAMDA) of zika, dengue, and chikungunya virus from human serum

Cited by 53 publications

References 42 publications

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Dengue Detection: Advances in Diagnostic Tools from Conventional Technology to Point of Care

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

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