Label-free biosensors based on in situ formed and functionalized microwires in microfluidic devices

Xing, Yanlong; Wyss, Andreas; Esser, N.; Dittrich, Petra S.

doi:10.1039/c5an01240f

Cited by 22 publications

(14 citation statements)

References 26 publications

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“…Nanomolar LODs of dopamine and serotonin in simulated body fluid have been achieved using a graphene-Au nanopyramid heterostructure platform [ 37 ]. Label-free SERS sensors have been employed to study the synthesis of dopamine with the detection of dopamine, norepinephrine, tyrosine, and phenylalanine [ 38 ]. The selective capture of dopamine can be achieved using metal nanoparticles modified with a dopamine-selective probe.…”

Section: Neurological Diseasesmentioning

confidence: 99%

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

et al. 2018

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For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the physiological environment. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy that allows for label-free, highly sensitive, and selective detection of analytes through the amplification of localized electric fields on the surface of a plasmonic material when excited with monochromatic light. This results in enhancement of the Raman scattering signal, which allows for the detection of low concentration analytes, giving rise to the use of SERS as a diagnostic tool for disease. Here, we present a review of recent developments in the field of in vivo and in vitro SERS biosensing for a range of disease states including neurological disease, diabetes, cardiovascular disease, cancer, and viral disease.

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Section: Neurological Diseasesmentioning

confidence: 99%

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

et al. 2018

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“…Polypyrrole NW-based FET [ 88 ] and vertical germanium NW array [ 89 ] were reported for their excellent and tunable sensitivity towards pH variations in microfluidic channels. In situ synthesized Au-TTF metal-organic wires showed the sensing abilities to catecholamines and antigens after different surface functionalization [ 90 ]. Inorganic silica NWs were developed into a multifunctional optical sensor that utilized the evanescent field of a subwavelength NW waveguide to perform optical spectroscopy on femtoliter probe volumes [ 91 ].…”

Section: Microfluidic-assisted Analytical Application Of 1d Nanostmentioning

confidence: 99%

One-Dimensional Nanostructures: Microfluidic-Based Synthesis, Alignment and Integration towards Functional Sensing Devices

Xing

Dittrich

2018

Sensors

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Microfluidic-based synthesis of one-dimensional (1D) nanostructures offers tremendous advantages over bulk approaches e.g., the laminar flow, reduced sample consumption and control of self-assembly of nanostructures. In addition to the synthesis, the integration of 1D nanomaterials into microfluidic chips can enable the development of diverse functional microdevices. 1D nanomaterials have been used in applications such as catalysts, electronic instrumentation and sensors for physical parameters or chemical compounds and biomolecules and hence, can be considered as building blocks. Here, we outline and critically discuss promising strategies for microfluidic-assisted synthesis, alignment and various chemical and biochemical applications of 1D nanostructures. In particular, the use of 1D nanostructures for sensing chemical/biological compounds are reviewed.

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“…A well‐defined interface is established between two co‐flowing fluids, where anisotropic structures can be assembled. Various 1D structures have been synthesized on‐chip in the past, such as metallic micro‐ and nanowires, metal‐organic fibers, or biological nanofibers . By additional use of sheath flows, the reaction zone could be further minimized, as reported for poly(methyl methacrylate) micro‐ and nanofibers .…”

Section: Introductionmentioning

confidence: 99%

Formation of Single Micro‐ and Nanowires with Extreme Aspect Ratios in Microfluidic Channels

Lenz

Sebastian

Dittrich

2019

Small

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Shown here is the site‐specific formation of single extraordinarily long metal–organic micro‐ and nanowires using a microfluidic device made of poly(dimethylsiloxane) (PDMS). This approach exploits two concepts, i) the diffusion of organic precursor molecules through PDMS and ii) the use of microfluidic channels as a growth template. To initiate wire formation, metal and organic precursor solutions are filled into different supply channels that are separated by PDMS. As the precursor diffuses through PDMS, and thereby infiltrates the adjacent channel, the growth of micro‐ and nanowires starts at the side walls of this adjacent channel. The formation yields single wires with sizes ranging from several hundreds of micrometers to millimeters at diameters of 0.5–2 µm. The principles of this formation pathway are demonstrated with the reaction of tetrathiafulvalene (TTF) and gold(III) ions that yields Au‐TTF wires. The influence of various reaction parameters including the choice of solvents and the chip fabrication protocol on the reaction are evaluated. Based on these findings, a further microfluidic device design with orthogonally arranged channels is developed, and the formation of single wires in a channel‐defined pattern is demonstrated. Moreover, the possibility of pulsed precursor supply allows for advanced control over the growth of the wires.

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Label-free biosensors based on in situ formed and functionalized microwires in microfluidic devices

Cited by 22 publications

References 26 publications

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

One-Dimensional Nanostructures: Microfluidic-Based Synthesis, Alignment and Integration towards Functional Sensing Devices

Formation of Single Micro‐ and Nanowires with Extreme Aspect Ratios in Microfluidic Channels

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