Label-free electrochemical aptasensor based on magnetic α-Fe2O3/Fe3O4 heterogeneous hollow nanorods for the detection of cancer antigen 125

Ni, Yun; Ouyang, Hezhong; Yu, Lulu; Chen, Ling; Zhu, Ziye; He, Aolin; Liu, Ruijiang

doi:10.1016/j.bioelechem.2022.108255

Cited by 27 publications

(5 citation statements)

References 46 publications

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“…Ni et al designed a label-free aptasensor for cancer antigen 125 (CA125) by modification of the electrode using magnetic α-Fe 2 O 3 /Fe 3 O 4 /Au nanocomposite followed by immobilization of the partial complementary strand on the electrode. As shown in Figure 4A, in the presence of CA125, the aptamer is released from the complementary strand, and the current is increased [83]. Moreover, recently, a new generation of electrochemical sensors was developed based on the CRISPR-Cas systems.…”

Section: Biosensorsmentioning

confidence: 99%

Aptamer-Based Targeting of Cancer: A Powerful Tool for Diagnostic and Therapeutic Aims

Mohammadinejad,

Gaman,

Aleyaghoob

et al. 2024

Biosensors

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Cancer is known as one of the most significant causes of death worldwide, and, in spite of novel therapeutic methods, continues to cause a considerable number of deaths. Targeted molecular diagnosis and therapy using aptamers with high affinity have become popular techniques for pathological angiogenesis and cancer therapy scientists. In this paper, several aptamer-based diagnostic and therapeutic techniques such as aptamer–nanomaterial conjugation, aptamer–drug conjugation (physically or covalently), and biosensors, which have been successfully designed for biomarkers, were critically reviewed. The results demonstrated that aptamers can potentially be incorporated with targeted delivery systems and biosensors for the detection of biomarkers expressed by cancer cells. Aptamer-based therapeutic and diagnostic methods, representing the main field of medical sciences, possess high potential for use in cancer therapy, pathological angiogenesis, and improvement of community health. The clinical use of aptamers is limited due to target impurities, inaccuracy in the systematic evolution of ligands via exponential enrichment (SELEX)stage process, and in vitro synthesis, making them unreliable and leading to lower selectivity for in vivo targets. Moreover, size, behavior, probable toxicity, low distribution, and the unpredictable behavior of nanomaterials in in vivo media make their usage in clinical assays critical. This review is helpful for the implementation of aptamer-based therapies which are effective and applicable for clinical use and the design of future studies.

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Section: Biosensorsmentioning

confidence: 99%

Aptamer-Based Targeting of Cancer: A Powerful Tool for Diagnostic and Therapeutic Aims

Mohammadinejad,

Gaman,

Aleyaghoob

et al. 2024

Biosensors

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“…Especially, the various magnetic nanostructures play a key role in the development of electrochemical biosensors that can detect cancer biomarkers, antigens, antibodies, and proteins [ 173 , 174 ]. The recent development of magnetic heterogeneous hollow nanorods containing α-Fe 2 O 3 /Fe 3 O 4 -Au was successful in detecting tumor antigen 125 using voltammetry techniques [ 175 ]. In addition to its low cost and convenience of preparation, the reported electrochemical aptasensor is convenient to use, indicating that it has potential clinical applications.…”

Section: Cancer Diagnosismentioning

confidence: 99%

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

et al. 2023

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The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools for cancer diagnosis and treatment in the future. Due to their tunable morphologies and superior properties, multifunctional magnetic nanomaterials and their hybrid nanostructures can be designed as specific carriers of drugs, imaging agents, and magnetic theranostics. Multifunctional magnetic nanostructures are promising theranostic agents due to their ability to diagnose and combine therapies. This review provides a comprehensive overview of the development of advanced multifunctional magnetic nanostructures combining magnetic and optical properties, providing photoresponsive magnetic platforms for promising medical applications. Moreover, this review discusses various innovative developments using multifunctional magnetic nanostructures, including drug delivery, cancer treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal agents, magnetic resonance imaging, and tissue engineering. Additionally, artificial intelligence (AI) can be used to optimize material properties in cancer diagnosis and treatment, based on predicted interactions with drugs, cell membranes, vasculature, biological fluid, and the immune system to enhance the effectiveness of therapeutic agents. Furthermore, this review provides an overview of AI approaches used to assess the practical utility of multifunctional magnetic nanostructures for cancer diagnosis and treatment. Finally, the review presents the current knowledge and perspectives on hybrid magnetic systems as cancer treatment tools with AI models.

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“…In fact, RNA-based aptamers were first found in 1990, followed by DNA-based aptamers, with the development of in vitro selection/amplification for the isolation of RNA sequences that could specifically bind to molecules [ 76 ]. In aptamer-based electrochemical sensors, it is necessary to be able to detect the conformational changes caused by the presence of the aptamer on the electrode surface for obtaining a signal [ 77 ]. Aptamers are widely used in the development of biosensors due to their high specificity, easy synthesis, simple modification and high chemical stability [ 78 ].…”

Section: Biorecognition Elements For Label-free Electrochemical Cance...mentioning

confidence: 99%

Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges

Şanko

Kuralay

2023

Biosensors

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With its fatal effects, cancer is still one of the most important diseases of today’s world. The underlying fact behind this scenario is most probably due to its late diagnosis. That is why the necessity for the detection of different cancer types is obvious. Cancer studies including cancer diagnosis and therapy have been one of the most laborious tasks. Since its early detection significantly affects the following therapy steps, cancer diagnosis is very important. Despite researchers’ best efforts, the accurate and rapid diagnosis of cancer is still challenging and difficult to investigate. It is known that electrochemical techniques have been successfully adapted into the cancer diagnosis field. Electrochemical sensor platforms that are brought together with the excellent selectivity of biosensing elements, such as nucleic acids, aptamers or antibodies, have put forth very successful outputs. One of the remarkable achievements of these biomolecule-attached sensors is their lack of need for additional labeling steps, which bring extra burdens such as interference effects or demanding modification protocols. In this review, we aim to outline label-free cancer diagnosis platforms that use electrochemical methods to acquire signals. The classification of the sensing platforms is generally presented according to their recognition element, and the most recent achievements by using these attractive sensing substrates are described in detail. In addition, the current challenges are discussed.

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Label-free electrochemical aptasensor based on magnetic α-Fe2O3/Fe3O4 heterogeneous hollow nanorods for the detection of cancer antigen 125

Cited by 27 publications

References 46 publications

Aptamer-Based Targeting of Cancer: A Powerful Tool for Diagnostic and Therapeutic Aims

Aptamer-Based Targeting of Cancer: A Powerful Tool for Diagnostic and Therapeutic Aims

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges

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