Label-free electrochemical immunosensor for ultrasensitive determination of cardiac troponin I based on porous fluffy-like AuPtPd trimetallic alloyed nanodendrites

Cen, Shi-Yun; Ge, Xin-Yue; Chen, Yao; Wang, Ai‐Jun; Feng, Jiu‐Ju

doi:10.1016/j.microc.2021.106568

Cited by 28 publications

(6 citation statements)

References 53 publications

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“…The AuPtPd FNDs’ increased catalytic activity is primarily due to two factors: (i) the tri-metals’ synergistic activity accelerates electron transport, and (ii) the metallic dendritic nanostructures have a large surface area and many active sites, resulting in increased catalytic activity. In the near future, this biosensor can also be used to detect different cardiac biomarkers in real samples [ 126 ].…”

Section: Macro-molecules Detection Using Metallic Nanodendrite-based ...mentioning

confidence: 99%

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Nano-Engineered Surface Comprising Metallic Dendrites for Biomolecular Analysis in Clinical Perspective

et al. 2022

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Metallic dendrites, a class of three-dimensional nanostructured materials, have drawn a lot of interests in the recent years because of their interesting hierarchical structures and distinctive features. They are a hierarchical self-assembled array of primary, secondary, and terminal branches with a plethora of pointed ends, ridges, and edges. These features provide them with larger active surface areas. Due to their enormous active areas, the catalytic activity and conductivity of these nanostructures are higher as compared to other nanomaterials; therefore, they are increasingly used in the fabrication of sensors. This review begins with the properties and various synthetic approaches of nanodendrites. The primary goal of this review is to summarize various nanodendrites-engineered biosensors for monitoring of small molecules, macromolecules, metal ions, and cells in a wide variety of real matrices. Finally, to enlighten future research, the limitations and future potential of these newly discovered materials are discussed.

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Section: Macro-molecules Detection Using Metallic Nanodendrite-based ...mentioning

confidence: 99%

“… ( I ) Pictorial representation of AuPtPd trimetallic fluffy-like nanodendrites (FNDs)-based sensor for identification of cardiac troponin I (cTnI). Reprinted with permission from [ 126 ]. Copyright 2021, Cen et al ( II ) Schematic showing the ( A ) Synthesis of Ab2-PdPt NDs@NH 2 -MIL-53(Fe), ( B ) Decoration of immunosensor.…”

Section: Figurementioning

confidence: 99%

Nano-Engineered Surface Comprising Metallic Dendrites for Biomolecular Analysis in Clinical Perspective

et al. 2022

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“…Nanobiosensors have shown improved analytical performance due to their large surface area and increased catalytic and conductive activity [ 33 , 34 , 35 , 36 ]. However, most of them still suffer from drawbacks such as material degradation, bioreceptor stability, and sluggish electron kinetics.…”

Section: Introductionmentioning

confidence: 99%

Clinically Deployable Bioelectronic Sensing Platform for Ultrasensitive Detection of Transferrin in Serum Sample

Kaur

Chittineedi

Bellala³

et al. 2023

Biosensors

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Varying levels of transferrin (Tf) have been associated with different disease conditions and are known to play a crucial role in various malignancies. Regular monitoring of the variations in Tf levels can be useful for managing related diseases, especially for the prognosis of certain cancers. We fabricated an immunosensor based on graphene oxide (GO) nanosheets to indirectly detect Tf levels in cancer patients. The GO nanosheets were deposited onto an indium tin oxide (ITO)-coated glass substrate and annealed at 120 °C to obtain reduced GO (rGO) films, followed by the immobilization of an antibody, anti-Tf. The materials and sensor probe used were systematically characterized by UV–Visible spectroscopy (UV–Vis), X-ray diffraction (XRD), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FTIR). Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) were also used for the stepwise sensor probe characterizations and Tf detection in serum samples, respectively. The anti-Tf/rGO/ITO immunosensor DPV output demonstrated an excellent Tf detection capability in the linear range of 0.1 mg mL−1 to 12 mg mL−1 compared to the enzyme-linked immunosorbent assay (ELISA) detection range, with a limit of detection (LOD) of 0.010 ± 0.007 mg mL−1. Furthermore, the results of the fabricated immunosensor were compared with those of the ELISA and autobioanalyzer techniques, showing an outstanding match with < 5% error and demonstrating the immunosensor’s clinical potential.

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“…[25,26]. For example, Barman et al reported a AuPtPd nanocomposites on -COOH terminated graphene oxide for analysis of prostate biomarkers [27], and Cen et al introduced an immunosensor based on ultrasensitive label-free AuPtPd porous fluffy-like nanodendrites for detecting cardiac troponin I [28]. In addition, multi-walled carbon nanotubes (MWCNTs) have vast applications in electrochemical fields for the large surface area and efficient electrons transfer which improves electrochemical activity and sensitivity of the electrochemical sensor.…”

Section: Introductionmentioning

confidence: 99%

Development of Sensitive Electrochemical Sensor Based on Chi-Tosan/MWCNTs-AuPtPd Nanocomposites for Detection of Bisphenol A

Han¹,

Pan²,

Li³

et al. 2023

Preprint

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A sensitive electrochemical sensor based on AuPtPd trimetallic nanoparticles functionalized multi-walled carbon nanotubes coupled with chitosan modified glassy carbon electrode (GCE/CS/MWCNTs-AuPtPd) for the rapid detection of bisphenol A (BPA) was proposed. AuPtPd trimetallic nanoparticles were first assembled on MWCNTs to obtain MWCNTs-AuPtPd nanocomposite. Then the MWCNTs-AuPtPd was further dispersed on the surface of chitosan modified electrode surface to fabricate the GCE/CS/MWCNTs-AuPtPd sensor. Due to the superior catalytic properties of MWCNTs-AuPtPd and the good film formation of chitosan, the constructed sensor displayed good performances for BPA detection. The structural morphology of CS/MWCNTs-AuPtPd was characterized by many methods, such as SEM, UV-vis and TEM. Under the optimal conditions, the designed sensor showed a linear range from 0.05 to 100 µM for BPA detecting with a low detection limit of 1.4 nM. The designed sensor was further used to realize the determination of BPA in real samples and the recoveries ranged from 94.4% to 103.6%. The results demonstrated that the electrochemical sensor designed by CS/MWCNTs-AuPtPd nanocomposites was reliable and could be a useful tool for the monitoring of food safety.

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Label-free electrochemical immunosensor for ultrasensitive determination of cardiac troponin I based on porous fluffy-like AuPtPd trimetallic alloyed nanodendrites

Cited by 28 publications

References 53 publications

Nano-Engineered Surface Comprising Metallic Dendrites for Biomolecular Analysis in Clinical Perspective

Nano-Engineered Surface Comprising Metallic Dendrites for Biomolecular Analysis in Clinical Perspective

Clinically Deployable Bioelectronic Sensing Platform for Ultrasensitive Detection of Transferrin in Serum Sample

Development of Sensitive Electrochemical Sensor Based on Chi-Tosan/MWCNTs-AuPtPd Nanocomposites for Detection of Bisphenol A

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