Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo

Hai, Pengfei; Qu, Yuan; Li, Yang; Zhu, Linyu; Shmuylovich, Leonid; Cornelius, Lynn A.; Wang, Lihong V.

doi:10.1117/1.jbo.25.3.036002

Cited by 29 publications

(22 citation statements)

References 42 publications

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“…Hence, we also want to refer to emerging novel techniques under current investigation, which might significantly improve the accuracy of early CM diagnosis. A variety of innovative optical and acoustic technology-based techniques, such as confocal laser-scanning microscopy, optical coherence tomography (OCT), photoacoustic/ultrasound/OCT, multiphoton excited fluorescence imaging, and stepwise two-photon excited fluorescence, have been developed to increase the diagnostic accuracy for the non-invasive melanoma diagnosis [ 118 , 119 , 120 , 121 , 122 , 123 , 124 ]. Advancing diagnostic tools and biomarkers to identify subgroup beneficiaries of specific treatment combinations prior to therapy can thus become the next step in patient-centered personalized CM treatment.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Advances in Targeting Cutaneous Melanoma

Kasakovski

Skrygan

Gambichler

et al. 2021

Cancers

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To date, the skin remains the most common cancer site among Caucasians in the western world. The complex, layered structure of human skin harbors a heterogenous population of specialized cells. Each cell type residing in the skin potentially gives rise to a variety of cancers, including non-melanoma skin cancer, sarcoma, and cutaneous melanoma. Cutaneous melanoma is known to exacerbate and metastasize if not detected at an early stage, with mutant melanomas tending to acquire treatment resistance over time. The intricacy of melanoma thus necessitates diverse and patient-centered targeted treatment options. In addition to classical treatment through surgical intervention and radio- or chemotherapy, several systemic and intratumoral immunomodulators, pharmacological agents (e.g., targeted therapies), and oncolytic viruses are trialed or have been recently approved. Moreover, utilizing combinations of immune checkpoint blockade with targeted, oncolytic, or anti-angiogenic approaches for patients with advanced disease progression are promising approaches currently under pre-clinical and clinical investigation. In this review, we summarize the current ‘state-of-the-art’ as well as discuss emerging agents and regimens in cutaneous melanoma treatment.

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Section: Conclusion and Future Perspectivementioning

confidence: 99%

Advances in Targeting Cutaneous Melanoma

Kasakovski

Skrygan

Gambichler

et al. 2021

Cancers

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“…A wide variety of background phantom materials was observed, including water, 46 , 47 Intralipid, 48 – 50 and various TMMs such as hydrogels (agar, gelatin, and polyvinyl alcohol), 51 – 56 polyurethane, 57 – 59 silicone, 60 gel wax, 8 styrene-ethylene/butylene-styrene polymer, 61 polydimethylsiloxane, 62 , 63 and polyvinyl chloride plastisol (PVCP). 48 , 64 , 65 Of the 119 studies of interest, 64 (54%) performed testing on targets immersed in non-turbid water baths or gels, rather than embedded in tissue-mimicking phantoms.…”

Section: Current Image Quality Evaluation Practices In Photoacoustic Imagingmentioning

confidence: 99%

Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment

et al. 2021

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. Significance : Photoacoustic imaging (PAI) is a powerful emerging technology with broad clinical applications, but consensus test methods are needed to standardize performance evaluation and accelerate translation. Aim : To review consensus image quality test methods for mature imaging modalities [ultrasound, magnetic resonance imaging (MRI), x-ray CT, and x-ray mammography], identify best practices in phantom design and testing procedures, and compare against current practices in PAI phantom testing. Approach : We reviewed scientific papers, international standards, clinical accreditation guidelines, and professional society recommendations describing medical image quality test methods. Observations are organized by image quality characteristics (IQCs), including spatial resolution, geometric accuracy, imaging depth, uniformity, sensitivity, low-contrast detectability, and artifacts. Results : Consensus documents typically prescribed phantom geometry and material property requirements, as well as specific data acquisition and analysis protocols to optimize test consistency and reproducibility. While these documents considered a wide array of IQCs, reported PAI phantom testing focused heavily on in-plane resolution, depth of visualization, and sensitivity. Understudied IQCs that merit further consideration include out-of-plane resolution, geometric accuracy, uniformity, low-contrast detectability, and co-registration accuracy. Conclusions : Available medical image quality standards provide a blueprint for establishing consensus best practices for photoacoustic image quality assessment and thus hastening PAI technology advancement, translation, and clinical adoption.

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“…Identification of circulating melanoma cells in the superficial venous system of human subjects was also achieved with a PAT system. However, more extensive studies are needed to determine the value of including this imaging method in the staging of this neoplastic disease (Hai et al, 2020).…”

Section: Tumorsmentioning

confidence: 99%

Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience

Bodea

Westmeyer

2021

Front. Neurosci.

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A prominent goal of neuroscience is to improve our understanding of how brain structure and activity interact to produce perception, emotion, behavior, and cognition. The brain’s network activity is inherently organized in distinct spatiotemporal patterns that span scales from nanometer-sized synapses to meter-long nerve fibers and millisecond intervals between electrical signals to decades of memory storage. There is currently no single imaging method that alone can provide all the relevant information, but intelligent combinations of complementary techniques can be effective. Here, we thus present the latest advances in biomedical and biological engineering on photoacoustic neuroimaging in the context of complementary imaging techniques. A particular focus is placed on recent advances in whole-brain photoacoustic imaging in rodent models and its influential role in bridging the gap between fluorescence microscopy and more non-invasive techniques such as magnetic resonance imaging (MRI). We consider current strategies to address persistent challenges, particularly in developing molecular contrast agents, and conclude with an overview of potential future directions for photoacoustic neuroimaging to provide deeper insights into healthy and pathological brain processes.

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Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo

Cited by 29 publications

References 42 publications

Advances in Targeting Cutaneous Melanoma

Advances in Targeting Cutaneous Melanoma

Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment

Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience

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