Label-free highly sensitive detection of (small) molecules by wavelength interrogation of integrated optical chips

Cottier, Kaspar; Wiki, M.; Voirin, Guy; Gao, Hui; Kunz, R.

doi:10.1016/s0925-4005(03)00117-5

Cited by 93 publications

(73 citation statements)

References 24 publications

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“…Therefore, the struc− tures with grating couplers of the high groove density c are frequently preferred. The obtained detection limits involv− ing the change of effective refractive index (DN) min and the refractive index of the cover (Dn c ) min are comparable with the parameters of the commercially available instrument [18], as well as with the parameters of similar structures pre− sented by other authors [1,[35][36][37][38]. In Ref.…”

Section: Detection Limitssupporting

confidence: 76%

Embossable grating couplers for planar evanescent wave sensors

Karasiński

2011

Opto-Electronics Review

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The paper presents input grating couplers to be applied in planar evanescent wave sensors. Waveguide films SiO2:TiO2 were obtained using the sol-gel method, and grating couplers with a groove density of 1000 g/mm and 2400 g/mm were produced using the method of master grating embossing in sol film. The influence of refractive index of the cover on incoupling angles was presented. Basing on the experimental results, detection limits involving the changes of effective indexes and refractive indexes of the cover for the investigated planar structures were determined. Sensor structures with the couplers having a groove density of 1000 g/mm enable to detect minimum changes of the effective index below 3.3×10−7 and to detect minimum changes of refractive index of the cover below 2.3×10−6. Detection limits for the structures with couplers having the groove density of 2400 g/mm are over twofold higher.

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Section: Detection Limitssupporting

confidence: 76%

Embossable grating couplers for planar evanescent wave sensors

Karasiński

2011

Opto-Electronics Review

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“…The master was a dry etched glass grating ( Figure 2) with a period of 360 AE 1 nm and a depth of 12 AE 1 nm. This particular grating structure is used in wavelength interrogated optical sensors (WIOS) used for immuno-assay purposes as described in the work of Cottier et al [31] The material to imprint was dispersed on the master and covered with a glass slide the surface of which was activated by plasma treatment during 30 s with a high frequency generator (BD20V, Electro-technik products Inc.) for better adhesion of the polymer material. Pressure was applied while the material was polymerized through the quartz window.…”

Section: Uv Lamp and Spectrometermentioning

confidence: 99%

Nanoimprint Lithography with UV‐Curable Hyperbranched Polymer Nanocomposites

Geiser

Jin

Leterrier

2010

Macromolecular Symposia

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Summary: Nano-scale patterns were produced with UV-curable acrylated hyperbranched polymer nanocomposites using nanoimprint lithography with a glass master in a rapid, low-pressure process. The pattern of the glass master was replicated with composites containing up to 25 vol% SiO 2 with a shape fidelity better than 98%. Photo-rheology, interferometry and atomic force microscopy were used to analyze the material behavior. Attention was paid to the relationship between composition, nanoparticle dispersion, kinetics of photo-polymerisation, shrinkage, pressure and shape fidelity of nano-gratings. It was shown that the gel-point of the nanocomposite was an important factor that determined the stability as well as the dimensions of the imprinted structure. Dimensional accuracy also strongly depended on the level of internal stress, which in fact increased with the amount of silica. A resin rich layer on the surface of the composite accounted for the good surface quality of the nano-pattern.

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“…8 The WIOS sensing principle is based on using a collimated light beam from a vertical cavity surface emitting laser (VCSEL) as wavelength-tunable source (763 nm AE 2 nm tuning range) for exciting waveguide modes in a dielectric waveguide by means of an input grating coupler ( Fig. 1(1)).…”

Section: Optical Transduction Principlementioning

confidence: 99%

Lab-on-a-chip for multiplexed biosensing of residual antibiotics in milk

et al. 2009

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A multiplexed immunoassay-based antibiotic sensing device integrated in a lab-on-a-chip format is described. The approach is multidisciplinary and involves the convergent development of a multiantibiotic competitive immunoassay based on sensitive wavelength interrogated optical sensor (WIOS) technology and a polymer-based self-contained microfluidic cartridge. Immunoassay solutions are pressure-driven through external and concerted actuation of a single syringe pump and multiposition valve. Moreover, the use of a novel photosensitive material in a 'one step' fabrication process allowed the rapid fabrication of microfluidic components and interconnection port simultaneously. Pre-filled microfluidic cartridges were used as binary response rapid tests for the simultaneous detection of three antibiotic families -sulfonamides, fluoroquinolones and tetracyclines -in raw milk. For test interpretation, any signal lower than the threshold value obtained for the corresponding Maximum Residue Limit (MRL) concentration (100 mg L À1 ) was considered negative for a given antibiotic. The reliability of the multiplexed detection system was assessed by way of a validation test carried out on a series of six blind milk samples. A test accuracy of 95% was calculated from this experiment. The whole immunoassay procedure is fast (less than 10 minutes) and easy to handle (automated actuation).

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Label-free highly sensitive detection of (small) molecules by wavelength interrogation of integrated optical chips

Cited by 93 publications

References 24 publications

Embossable grating couplers for planar evanescent wave sensors

Embossable grating couplers for planar evanescent wave sensors

Nanoimprint Lithography with UV‐Curable Hyperbranched Polymer Nanocomposites

Lab-on-a-chip for multiplexed biosensing of residual antibiotics in milk

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