2024
DOI: 10.1021/acssensors.4c00590
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Label-Free Measurement of CD63 Positive Extracellular Vesicles Using Terahertz Chemical Microscopy

Changjiang Liu,
Jin Wang,
Ryo Negishi
et al.

Abstract: Extracellular vesicles (EVs) are small cellular organelles involved in intracellular signaling and cell-to-cell interactions. Recent studies suggested that exosomes may have potential applications in the diagnosis and treatment of cancer and neurodegenerative diseases. In this study, extracellular vesicles of the human nonsmall cell lung cancer cell line H1299 and the unlabeled antiCD63 antibody were imaged using a new label-free terahertz chemical microscopy (TCM) technique to detect changes in the terahertz … Show more

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