Label-free silicon photonic biosensors for use in clinical diagnostics

Fard, Sahba Talebi; Grist, Samantha M.; Donzella, Valentina; Schmidt, Shon; Flueckiger, Jonas; Wang, Xu; Shi, Wei; Millspaugh, Andrew; Webb, Mitchell; Ratner, Daniel M.; Cheung, Karen C.; Chrostowski, Lukas

doi:10.1117/12.2005832

Cited by 35 publications

(5 citation statements)

References 29 publications

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“…The latter are the most common and consist of a circular structure (e.g., a micro-sphere, micro-disk, or micro-toroid), where the light is confined. Resonator biosensors can be found in arrangements such as silicon-on-isolator (SOI) [ 78 ], opto-fluidic ring resonator (OFRR) [ 79 ], subwavelength grating (SWG) [ 80 ] and whispering gallery mode (WGM) [ 81 ].…”

Section: Main Optical Biosensor Componentsmentioning

confidence: 99%

“…SOI are devices in which the ring is made of silicon. Due to the high refractive index of silicon, the optical modal field is strongly located near the surface of the waveguide, resulting in a high response to surface disturbances [ 78 ]. OFRR consists of a microtube that is functionalized on the inside, while a light source is outside.…”

Section: Main Optical Biosensor Componentsmentioning

confidence: 99%

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Optical Biosensors and Their Applications for the Detection of Water Pollutants

et al. 2023

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The correct detection and quantification of pollutants in water is key to regulating their presence in the environment. Biosensors offer several advantages, such as minimal sample preparation, short measurement times, high specificity and sensibility and low detection limits. The purpose of this review is to explore the different types of optical biosensors, focusing on their biological elements and their principle of operation, as well as recent applications in the detection of pollutants in water. According to our literature review, 33% of the publications used fluorescence-based biosensors, followed by surface plasmon resonance (SPR) with 28%. So far, SPR biosensors have achieved the best results in terms of detection limits. Although less common (22%), interferometers and resonators (4%) are also highly promising due to the low detection limits that can be reached using these techniques. In terms of biological recognition elements, 43% of the published works focused on antibodies due to their high affinity and stability, although they could be replaced with molecularly imprinted polymers. This review offers a unique compilation of the most recent work in the specific area of optical biosensing for water monitoring, focusing on both the biological element and the transducer used, as well as the type of target contaminant. Recent technological advances are discussed.

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Section: Main Optical Biosensor Componentsmentioning

confidence: 99%

Section: Main Optical Biosensor Componentsmentioning

confidence: 99%

Optical Biosensors and Their Applications for the Detection of Water Pollutants

et al. 2023

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“…Extensive research has been conducted in the field of biosensors based on Si photonics, resulting in the development of several types with diverse applications [ 168 , 169 , 170 , 171 , 172 , 173 , 174 ]. These biosensors utilize the advantageous properties of Si photonics to detect and analyze biological substances effectively.…”

Section: Si Photonics Sensorsmentioning

confidence: 99%

Breakthrough in Silicon Photonics Technology in Telecommunications, Biosensing, and Gas Sensing

Shahbaz,

Butt,

Piramidowicz

2023

Micromachines

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Silicon photonics has been an area of active research and development. Researchers have been working on enhancing the integration density and intricacy of silicon photonic circuits. This involves the development of advanced fabrication techniques and novel designs to enable more functionalities on a single chip, leading to higher performance and more efficient systems. In this review, we aim to provide a brief overview of the recent advancements in silicon photonic devices employed for telecommunication and sensing (biosensing and gas sensing) applications.

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“…The limit of detection (Δnmin) is the minimum possible resolution of nc required to obtain an observable shift in the resonant wavelength. The evaluation of various key device parameters is performed by adopting the procedures defined in the literature (Talebi et al 2013;. Theoretical determination of the device sensitivity is 90 nm/RIU (where RIU is refractive index unit).…”

Section: Characteristics Which Are Important For Biosensing Applicationsmentioning

confidence: 99%

High-Q and temperature stable photonic biosensor based on grating waveguides

et al. 2018

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2018). High-Q and temperature stable photonic biosensor based on grating waveguides. This is the accepted version of the paper. This version of the publication may differ from the final published version. Permanent repository link: http://openaccess.city.ac.uk/20188/ Link to published version: http://dx. Abstract.In this work, analytical modeling and parameter evaluation of a photonic biosensor using cascaded silicon grating waveguides is illustrated. The sensor design consists of two cascaded waveguides with symmetric sidewall gratings to broaden the stop band region of the transmission spectra. In the work, the structure is first analyzed using the transfer matrix method.The parameter values are then optimized to obtain a sharper resonant peak in the center of the stop band. Notably, the resonant band of this structure provides a high Q factor (of 1.544 × 10 5 ), which significantly improves the limits of detection. The sensor has been designed to detect the presence of biomaterial material (seen corresponding to a change in refractive index) on its surface by changing the change in device resonant wavelength. In this study, the effect of temperature on the detection of such biomaterials has also been evaluated, as has the temperature sensitivity of the device which is -0.0075nm/ o C, over a temperature range of 18 o C to 34 o C.

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Label-free silicon photonic biosensors for use in clinical diagnostics

Cited by 35 publications

References 29 publications

Optical Biosensors and Their Applications for the Detection of Water Pollutants

Optical Biosensors and Their Applications for the Detection of Water Pollutants

Breakthrough in Silicon Photonics Technology in Telecommunications, Biosensing, and Gas Sensing

High-Q and temperature stable photonic biosensor based on grating waveguides

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