“…2. The percentage of the labeling yield of [131I]-IodooPHPI was determined as the percent ratio of [131I]-IodooPHPI [81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100].…”
Section: Evaluation Of Radiochemical Yield By Tlc Paper Electrophores...mentioning
The drug, phenylpiracetam, (PHPI, Iodophenylpiracetam ([131 I]-PHPI)) can prevent retrograde amnesia, and has anticonvulsant properties in models of animal was labeled using [I-131]with Chloramine-T(Ch-T) as an oxidizing agent to give a radiochemical yield of 98%. Many operators such as the amount of oxidizi ng agent, amount of substrate, pH, and reaction time, was systematically studied giving optimum conversion (98%) was obtained. Biodistribution studies indicate the[131I]PHPI tracer focuses on the target organ (brain) with a high percentage that is appropriate to use as a novel tracer for brain imaging. A labeled compound of [131I]-PHPImay be considered a highly selective radiotracer for brain tumor imaging compared withcommercially available radiotracers [99mTc] ECD and [99mTc] HMPAO.
“…Appl., Vol. XX, X, (2023) than just the listed compounds of [ 131 I] iodosulfasalazine and [ 131 I] iodobalsalazide [100][101][102][103][104][105][106][107][108][109][110].…”
Section: -Investigations Using Molecular Modellingmentioning
Ulcerative colitis (UC) is a chronic, regressive natural disease. The use of conventional diagnostic procedures such as magnetic resonance imaging, ultrasonography, and X-rays during the dormant and early stages of the disease does not aid in diagnosing the disease. As a result, a novel design, such as labelled compounds, were used to image ulcerative colitis disease. In this study, olsalazine was labeled with [ 125/131 I] and the labelling parameters were adjusted to obtain a high radiochemical yield (98.5%). In addition, the olsalazine radiotracer gave 96.0% purity in rate serum for up to twelve hours before it started to degrade at twenty-four hours, and it was stable also, in saline for up to twentyfour hours. Molecular docking was used to assess a complex's affinity for its biological target, and the PPAR receptor. The biological assessment was also performed in mice models of both standard and ulcerative colitis. The results demonstrated that [ 125/131 I] iodoolsalazine had a high uptake of 79.5% (ID/g) at 120 minutes post-injection and is still high to 77% at 24 hours. So, the labelled compound, [ 125/131 I] iodoolsalazine, could be considered a new potential selective radiotracer for preclinical diagnostic research of ulcerative colitis.
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