2024
DOI: 10.1021/acschembio.4c00439
|View full text |Cite
|
Sign up to set email alerts
|

Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe

Lisa S. den Hollander,
Bert L.H. Beerkens,
Sebastian Dekkers
et al.

Abstract: Interest in affinity-based probes (AfBPs) as novel tools to interrogate G protein-coupled receptors (GPCRs) has gained traction in recent years. AfBPs represent an interesting and more versatile alternative to antibodies. In the present study, we report the development and validation of AfBPs that target the intracellular allosteric pocket of CCR2, a GPCR of interest for the development of therapies targeting autoimmune and inflammatory diseases and also cancer. Owing to the two-step labeling process of these … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 37 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?