Labeling of ursodeoxycholic acid with technetium-99m for hepatobiliary imaging

Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection

“…Being a tissue‐rich with angiotensin II receptor subtype II, the kidney showed high‐radioactivity uptake and low clearance augmented by low‐water solubility of 125 I‐CAN, equal to 5, 13, 30, and 21 at 5, 15, 30, and 60 minutes, respectively. A similar profile between liver and intestine was observed indicating some enterohepatic circulation . Results of the radioactive uptake of both kidney and liver are compatible with data published by Sidiqui et al who mentioned that the main elimination route of mother drug CAN is through hepatobiliary and urinary pathways .…”

Radiosynthesis and in silico bioevaluation of 131I‐Sulfasalazine as a highly selective radiotracer for imaging of ulcerative colitis

“…The percentage of uptake in kidneys was also low with 5.11% and 5.13% ID/ g at 3 hr incubation period while the percentage of liver uptake was elevated in both Tables having 39.23% and 37.5% ID/ g at 3 hr p.i according to sulfasalazine pharmacokinetic (Das & Dubin, 1976). Further, the uptake was observed to be reduced to give 1.2% and 1.1% ID/ g at 24 hr p.i in kidneys and 12% and 11.5% ID/ g at 24 hr p.i in the liver as depicted in Tables 1 and 2, respectively (Sanad & El&Tawoosy, 2013). Therefore, the radiotracer [ 131 I]‐SSD was washed out fundamentally through hepatobiliary pathways (Klotz, 1985).…”

Radioiodination of balsalazide, bioevaluation, and characterization as a highly selective radiotracer for imaging of ulcerative colitis in mice

“…HPLC analysis gave purity for [ 125/131 I]iodobalsalazide as 98% after complete purification. [47][48][49][50][51][52][53][54][55][56] 2.3 | Physicochemical estimation…”