The railway industry of the Republic of Uzbekistan is currently an emerging market for transport services that integrates into the global economy, primarily in the Asian space. This is explained by the fact that the Republic of Uzbekistan occupies a strategic geographical position in Central Asia and is the center of the region’s geopolitical development, the main transit corridors connecting the North and South, East and West of the continent pass through the territory of the Republic of Uzbekistan [1]. When organizing both freight and passenger rail traffic, the issues of ensuring their safety should be considered taking into account the parameters of economic sustainability, which is still not given due attention. Based on the analysis of the indicators and the assessment of traffic safety in JSC “Uzbekistan Temir Yollari”, the authors identified such planning steps as analyzing traffic safety indicators and identifying problems, analyzing the causes of the problems identified, forming the idea of a goal, checking the achievement of a goal, development of options for activities to achieve goals. For each stage, based on the methods of correlation, regression and factor analysis, algorithms for their implementation have been developed. A concept of measures has been developed with the aim of increasing the economic efficiency of traffic safety management depending on the method of control. The authors believe that the implementation of the proposed recommendations for decision-making on road safety is a comprehensive preventive measure to ensure a guaranteed level of economic security in the developing market of Uzbekistan.