Labor induction post-term with 25 micrograms vs. 50 micrograms of intravaginal misoprostol

Meydanli, M. Mutlu; Çalışkan, Eray; Burak, Feza; Narin, Mehmet Ali; Atmaca, Ruşen

doi:10.1016/s0020-7292(03)00042-0

Cited by 42 publications

(40 citation statements)

References 10 publications

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“…This is contrast to the finding of Meydanli et al [19] and Elhassan et al [17] Meydanli reported that more women delivered between 12-24 hours in the 25 µg group while El-hassan reported that fewer delivered vaginally in the 25 µg group. The explanation for the differences may be in the methodology.…”

Section: Discussioncontrasting

confidence: 86%

“…Although the study found that induction delivery interval was similar among the two groups, other investigators [13][14][15][16][17][18] had demonstrated that it was shorter in the 50 µg group. In a meta-analysis comparing 25 µg with 50 µg misoprostol, the induction vaginal delivery interval was nearly five hours shorter in the 50 µg group [19]. This difference as against meta-analysis may be due to small sample size and non-blinding of the study.…”

Section: Discussionmentioning

confidence: 94%

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A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

Adebayo¹,

Onafowokan²,

Adewole³

2017

J Women's Health Care

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Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 94%

A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

Adebayo¹,

Onafowokan²,

Adewole³

2017

J Women's Health Care

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“…3 However, the cases with failed induction were more common in low dose misoprostol, these finding was consistent with one of the study of meydanliet et al 4 Their study also reported that the proportion of women delivering vaginally with one dose of vaginal misoprostol was significantly greater in 50 g group (0/49 vs. 41/47;p>0.001) which was not studied in our cases. In a comparative study reported by Has et al showed the rate of Cesarian Section due to fetal distress was higher with higher dose (28.6 vs. 10.3% p>0.05).…”

Section: Resultssupporting

confidence: 91%

Comparative Evaluation of 25µg and 50µg of travaginal Misoprostol for Induction of Labor

Shrestha¹,

Jain²,

Maskey³

et al. 2013

J Lumbini Med Coll

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Introduction: To compare the efficacy and safety of 25g vs. 50g of intravaginal (Posterior fornix) misoprostol for induction of labor in 100 patient from Jan 2012 to Dec 2012 at Lumbini Medical College. Methods: One hundred pregnant lady requiring induction were randomly assigned to receive either 25 g (group A=50) or 50 g (group B=50) of intra vaginal misoprostol every 4 hrs till adequate contractions were achieved or maximum dose of 150 g was used. Results: The onset of contraction was earlier in group B in 34 cases as compared to group A, where only 25 cases had earlier contraction ( P> 0.05). 38 cases (76%) in Group B and 35 cases (70%) in Group A delivered vaginally. Induction to delivery interval was shorter(<12hrs) in group B in 15 cases and in 10 cases in group A. Mean dose of Misoprostol (94micrograms) for successful induction in group B was high compared to Group A (75.5 microgram). Requirement for oxytocin infusion was higher in group A, 26% vs. 15%. Abnormal contractility pattern was seen in B group 24% cases compared to 14% cases in Group A. APGAR score < 7 at 1 min was seen in 26% neonates in Group B and in only 10% neonates in Group A. Ruptured uterus did not occur in any group. Conclusion: 50 g dose of misoprostol is more efficacious than 25 g dose as seen in our study. However it appears to be less safe both for mother and baby due to the high incidence of tachysystole, hyperstimulation and intrauterine passage of meconium.

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“…Neonatal outcome were comparable. Similar to this study neonatal outcome (APGAR and NICU admission) was comparable in lower and higher dose vaginal misoprostol groups in the study by Makbib Diro et al, Ozsoy M, Meydanli MM et al and Kreft M. 10,11,14,15 …”

supporting

confidence: 89%

“…8 Has R et al and Myedanli MM reported similar results that the rate of uterine tachysystole and hyper stimulation syndrome was comparable in both groups. 10,13 In group A (25 mcg misoprostol), 1 minute APGAR <7 was seen in 3 (5.45%) neonates and in group B (50mcg misoprostol), 1 minute APGAR <7 was seen in 8 (14.55%). The difference in APGAR is not statistically significant, P value = 0.2036.…”

mentioning

confidence: 98%

A comparative study of 25µg versus 50µg vaginal misoprostol for induction of labour at term premature rupture of membrane

Sinha

Gupta

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONIn approximately 8 to 10% of pregnancies the membranes ruptures before the onset of labour. Premature rupture of membrane (PROM) is defined as spontaneous rupture of membranes anytime beyond 28 th week of pregnancy but before the onset of labour. When membrane rupture occurs beyond 37 weeks but before term, it is called Term PROM and when it occurs before 37 completed weeks it called preterm PROM.1 The short term risks of PROM include cord prolapse, cord compression and placental abruption. Whereas the long term risks include maternal infection (such as chorioamnionitis, postpartum endometritis, and sepsis) and more seriously, neonatal infection. 2Spontaneous labour follows term PROM at 24, 48, and 96 hours in 70%, 85% and 95% of women, respectively. Thus, an important proportion of women have significant latency from PROM to delivery if managed expectantly, particularly in nulliparous women. 3 The risk of intrauterine infection increases with the duration of PROM. The risk of chorioamnionitis with term PROM has been reported to be less than 10% and to increase to 40% after 24 hours of PROM. 4 The risk of intrauterine infection increases with duration of labour. Evidence supports the idea that ABSTRACT Background: At term, infection remains the most serious complication associated with PROM for the mother and the neonate Induction of labour significantly reduces the risk of maternal and foetal infection. This randomized comparative study has been done to compare the effectiveness and safety of low and high dosage (25 mcg and 50mcg) regimen of vaginal misoprostol for induction in term PROM patients. Methods: At term, infection remains the most serious complication associated with PROM for the mother and the neonate Induction of labour significantly reduces the risk of maternal and foetal infection. This randomized comparative study has been done to compare the effectiveness and safety of low and high dosage (25 mcg and 50mcg) regimen of vaginal misoprostol for induction in term PROM patients. Results: PROM to delivery interval was significantly shorter with 50mcg vaginal misoprostol as compared to 25 mcg vaginal misoprostol (15.71±3.29 hours vs. 18.23±3.23 hours, (p value = 0.0023) Number of doses required was less with 50mcg vaginal misoprostol group as compared to 25mcg vaginal misoprostol (1.22±0.42 vs. 1.91±0.80, p value <0.05). 83.6% women in group A and 69.09% women in group B underwent spontaneous vaginal delivery within 24 hours. 3.64% women in group A and 7.27% in group B had instrumental delivery. Caesarean section was performed in 12.27% cases in group A and 23.64% cases in group B. The complication rate was comparable. Conclusions: 50mcg vaginal misoprostol is more effective and safe for induction of labour at term PROM as compared to 25 mcg vaginal misoprostol

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Labor induction post-term with 25 micrograms vs. 50 micrograms of intravaginal misoprostol

Abstract: Intravaginal administration of 25 microg of misoprostol appears to be as effective as 50 microg for cervical ripening and labor induction beyond 41 weeks' gestation.

Cited by 42 publications

References 10 publications

A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

A Comparison of 25 μg with 50 μg Misoprostol for Cervical Ripening and Induction of Labor

Comparative Evaluation of 25µg and 50µg of travaginal Misoprostol for Induction of Labor

A comparative study of 25µg versus 50µg vaginal misoprostol for induction of labour at term premature rupture of membrane

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