Labor status of 137 patients with liver transplantation

Loinaz, Carmelo; Clemares, M; Marqués, E; Paseiro, G.; Gómez, R; González-Pinto, I; Jiménez, Carlos; García, Ignacio; Moreno, Enrique

doi:10.1016/s0041-1345(99)00422-4

Cited by 20 publications

(10 citation statements)

References 5 publications

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“…In this study, patients were asked to estimate the change in their working capacity or functional capacity in everyday life also if they had not actually returned to paid employment but were, for example, students or homemakers instead. In line with our results, Loinaz et al31 reported that 41% of patients returned to work an average of 2.6 months after LT in a study from their center in Spain. Our study further indicated a trend in which returning to work was dependent on age; the younger the patient was at the time of LT, the more likely and sooner he or she was to return to work.…”

Section: Discussionsupporting

confidence: 92%

Health-related quality of life and employment status of liver transplant patients

et al. 2009

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Health-related quality of life (HRQoL) is one preferable outcome measure of medical interventions such as liver transplantation (LT). The aim of this study was to compare HRQoL of LT patients with that of the general population and to assess the employment status of LT patients. HRQoL was measured with the 15D instrument, a validated, nondisease-specific, 15-dimensional, self-administered HRQoL instrument. The questionnaire was sent to all adult LT patients in Finland (401 patients) alive in June 2007. The response rate was 89% (353 patients). The results were compared to those of 6050 age-standardized and gender-standardized controls from the general population. LT patients (mean age, 55 years; range, 20-82) had slightly worse HRQoL scores than the general population (mean 15D score, 0.889 versus 0.907; P Ͻ 0.002). Survival time and retransplantation did not affect HRQoL significantly in age-adjusted and gender-adjusted analyses. HRQoL decreased with increasing age (P Ͻ 0.0001). Patients transplanted for acute liver failure (ALF) or chronic liver disease (CLD) had significantly worse HRQoL than the general population (P ϭ 0.014 and P ϭ 0.040). Forty-four percent of working-age patients were employed at the time of the study. Persons that were employed had significantly better HRQoL than those unemployed (15D scores, 0.934 versus 0.859; P Ͻ 0.0001). Eighty-seven percent of patients experienced improved working capacity after LT. Early retirement was the most common cause of unemployment (56% of unemployed patients), and those patients presented with worse HRQoL than patients unemployed for other reasons. In conclusion, HRQoL of LT patients is very close to that of the general population. Older age, CLD, and ALF impair HRQoL. Employment is an indicator of HRQoL. Liver Transpl 15:64-72, 2009.

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Section: Discussionsupporting

confidence: 92%

Health-related quality of life and employment status of liver transplant patients

et al. 2009

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“…Additionally, the specific analyses performed in those longitudinal studies using SF-36 as a common instrument demonstrated a lack of immediate improvement in several domains. While these data might be explained by insufficient follow up and also by the fact there were only two longitudinal studies with available data, they also raise questions about the level of restoration of QOL after LT. [6,10,17,[40][41][42]27,43,44] When analyzing specific issues related to QOL in LT patients some clues emerge about why the improvement of QOL is less than we might have expected. A close relationship has been established between underlying liver disease and QOL (see Table 6).…”

Section: Discussionmentioning

confidence: 99%

Quality of life after liver transplantation. A systematic review

Tomé

Wells

Said

et al. 2008

Journal of Hepatology

149

151

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“…A study by Loinaz et al 15 published since our metaanalysis provides a detailed evaluation of employment patterns of 137 patients before and after transplantation at a center in Madrid, Spain. Primary results are listed in Table 1.…”

Section: Employment After Liver Transplantationmentioning

confidence: 99%

Quality of life and employment after liver transplantation

Bravata

Keeffe

2001

Liver Transplantation

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Key Points 1. In general, the health-related quality of life (QOL) of transplant recipients is impaired before and improves after liver transplantation. 2. Transplant recipients report largest gains in those aspects of QOL most affected by physical health and smaller improvements in areas affected by psychological functioning. 3. No utility-based measures have been used with liver transplant recipients; therefore, the necessary QOL weights for use in cost-effectiveness evaluations of liver transplantation are lacking. 4. Pretransplantation, the percentage of candidates with alcoholic liver disease (ALD) who work is less than that of candidates without ALD. However, there is no difference in rates of employment posttransplantation. 5. No study has described types of wages and benefits associated with jobs before or after transplantation or the extent to which health insurance benefits associated with employment motivate changes in work status. 6. Many studies in this field used nonvalidated heterogeneous instruments to measure QOL and employment, thus limiting the opportunity to combine results across studies and compare outcomes for liver transplant recipients with other patient populations. (Liver Transpl 2001; 7:S119-S123.) C hronic liver disease and its complications are the ninth leading cause of death in the United States. In addition to its effect on mortality, end-stage liver disease has a profoundly negative impact on functional status outcomes. Patients with liver failure experience various degrees of hepatic encephalopathy, with reduced cognitive function as a result of toxic metabolites that are not cleared by the failing liver and cross the blood-brain barrier. 1 Other clinical manifestations of patients with hepatic encephalopathy include lability of affect, atypical emotional responses, depression, and anxiety. 2 Given that this psychological and intellectual deterioration occurs concomitantly with the physical deterioration associated with liver failure, it is not surprising that patients with end-stage liver disease should have significant impairment of quality of life (QOL), often associated with loss of employment.Liver transplantation is widely accepted as treatment for end-stage liver disease. Currently, more than 85% of adult liver transplant recipients survive the first year after transplantation, and 55% survive more than 9 years. 3 As clinical outcomes of liver transplantation improve, outcomes relating to transplant recipients' overall functional status and QOL become increasingly important targets for evaluation. We recently performed a comprehensive meta-analysis of patients' QOL and employment after liver transplantation from 89 studies that reported on 6,306 patients. [4][5][6] We sought to characterize the overall effect of liver transplantation on various aspects of QOL and describe long-term patterns of employment. Since the publication of this work, several important studies have been published on this topic. In this report, we describe primary results of the meta-analysis and di...

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Labor status of 137 patients with liver transplantation

Cited by 20 publications

References 5 publications

Health-related quality of life and employment status of liver transplant patients

Health-related quality of life and employment status of liver transplant patients

Quality of life after liver transplantation. A systematic review

Quality of life and employment after liver transplantation

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