Laboratory and Animal Model Evaluation of the Cryotech LCS 2000 in Hepatic Cryotherapy

Dilley, A.; Dy, David; Warlters, Andrea; Copeland, Stephen A.; Gillies, A.E.; Morris, Richard; Gibb, David; Cook, Timothy A.; Morris, David L.

doi:10.1006/cryo.1993.1007

Cited by 59 publications

(25 citation statements)

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“…It is characterized by capillary sprouting, migration of myofibroblasts, macrophage and giant cell reaction and the regeneration of small bile ducts and hepatocytes at the interface between well-preserved and the necrotic tissue. These findings are also supported by other groups [29,31]. In addition, tissue oedema present immediately after cryotherapy might contribute to a consistent overestimation of the lesion size 24 h postoperatively [32].…”

Section: Regeneration Within the Cryolesionsupporting

confidence: 81%

Hepatic Cryotherapy Involving the Vena cava

Eggstein

Neeff²,

Szarzynski³

et al. 2003

Eur Surg Res

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Liver tumors located near the retrohepatic vena cava are often considered nonresectable. For these patients cryoablation could be a therapeutic option. In this study the safety and efficacy of hepatic cryosurgery involving the retrohepatic vena cava were investigated. Cryolesions involving the vena cava were created in 26 pigs. Follow-up was 24 h and 14 days. The extent of the cryolesion, damage to the vena cava and complications were assessed after autopsy. The cyronecrosis extended into the wall of the vena cava in 81% of the animals. All animals had an uneventful recovery without any complications such as ruptures of the vessel, thrombosis or pulmonary embolism. Microscopically elastic and collagenous fibers of the cava wall remained intact. The continuity of the vessel wall was conserved. In conclusion, the safety and efficacy of cryosurgical treatment involving the retrohepatic vena cava were shown in a pig model.

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Section: Regeneration Within the Cryolesionsupporting

confidence: 81%

Hepatic Cryotherapy Involving the Vena cava

Eggstein

Neeff²,

Szarzynski³

et al. 2003

Eur Surg Res

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“…We hypothesise that raised biliary pressure caused by the onset of sclerosing cholangitis from FUDR results in leakage of bile into the necrotic areas of liver after cryotherapy. We have previously reported the pathological appearance of liver after hepatic cryotherapy in sheep [15], and a firm and eventually fibrous lesion is seen; the radiology of resolving cryolesions treated with 5-FU has also been described and does not include biloma [16]. Whereas FUDR has some advantage over 5-FU in avoiding arterial injury, we would caution against its use after cryotherapy.…”

Section: Discussionmentioning

confidence: 99%

Fluorodeoxyuridine causes bilomas after hepatic cryotherapy

et al. 1998

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“…Multiple probes can be used at the same time and, unlike RFA, will meld together rather than leaving small untreated areas which is a common predicament with multiple/overlapping application of RFA. A twin freeze thaw cycle is undoubtedly more effective but also has safety concerns [65] hence; we recommend just refreezing the edge (least well treated area) by allowing 1 cm to thaw then refreeze.…”

Section: Methodsmentioning

confidence: 99%

“…Other more treatable cryotherapy-related complications include hepatic abscess formation, haemorrhage, biliary injury and pleural effusion. Hepatic abscess is common (0.9% -11.8%) but usually seen when combined colonic resection and liver cryotherapy are performed synchronously [57,61,[64][65][66][69][70][71][72]. Bleeding from liver cracks can easily be controlled by pressure or suture [58,66,69].…”

Section: Perioperative Risksmentioning

confidence: 99%

“…There are 2 types of available systems for clinical purpose -using liquid nitrogen (Erbe Tubingen Germany; Spembly, Andover, UK; Cryotech, Ripley, UK; Cryomedical Science Inc, MD, USA; Candela, Eindhoven, The Netherlands) [56][57][58][59][60][61][62][63][64][65] and argon gas (Endocare, CA USA) [62,66,67]. Some have reusable probes which very significantly reduces costs.…”

Section: Cryotherapy Introductionmentioning

confidence: 99%

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Resection and Ablation for Colorectal Liver Metastases

Ng¹

2013

J Gastrointest Dig Syst

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The surgical approach combining resection and ablation allows for a greater number of patients with colorectal liver metastases who would otherwise be considered to have unresectable disease to be given an opportunity to undergo a curative attempt surgery. Ablation results in local destruction of tumour and is often employed in lesions that are in locations which are not easily resectable. This may involve the use of radiofrequency ablation that causes thermal destruction or cryotherapy that freezes tumours. This review examined the literature reporting resection and ablation of colorectal liver metastases.

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Laboratory and Animal Model Evaluation of the Cryotech LCS 2000 in Hepatic Cryotherapy

Cited by 59 publications

References 0 publications

Hepatic Cryotherapy Involving the Vena cava

Hepatic Cryotherapy Involving the Vena cava

Fluorodeoxyuridine causes bilomas after hepatic cryotherapy

Resection and Ablation for Colorectal Liver Metastases

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