Laboratory and Clinical Acute Effects of Active and Passive Indoor Group Water-Pipe (Narghile) Smoking

Bentur, Lea; Hellou, Elias; Goldbart, Aviv; Pillar, Giora; Monovich, Einat; Salameh, Maram; Scherb, Inna; Bentur, Yedidia

doi:10.1378/chest.13-0960

Cited by 60 publications

(68 citation statements)

References 37 publications

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“…On the other hand, an increase in leukocyte count has been reported in humans exposed acutely to WPS (one session of 30 min), however, no measurement of proinflammatory cytokine in plasma has been reported [21]. The discrepancy between this finding [21] and ours could be related to the time-point and/or to the fact humans exposed to WPS had previous exposure to WPS and/or cigarette that may predispose them more to develop an increase in white blood cell count following acute WPS exposure compared to mice.…”

Section: Discussionmentioning

confidence: 99%

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Short-Term Nose-Only Water-Pipe (Shisha) Smoking Exposure Accelerates Coagulation and Causes Cardiac Inflammation and Oxidative Stress in Mice

Yuvaraju

Beegam

Ali

2015

Cell Physiol Biochem

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Background/Aim: Water-pipe smoking (WPS) has acquired worldwide popularity, and is disseminating particularly rapidly in Europe and North America. However, little is known about the short-term cardiovascular effects of WPS. Methods: Presently, we assessed the short-term cardiovascular effects of nose-only exposure to mainstream WPS in BALB/c mice for 30 min/day for 5 consecutive days. Control mice were exposed to air. At the end of the exposure period, several cardiovascular endpoints were measured. Results: WPS did not affect the number of leukocytes and the plasma concentrations of C-reactive protein, tumor necrosis factor α (TNFα) and interleukin-6 (IL-6). Likewise, plasma levels of lipid peroxidation (LPO), reduced glutathione (GSH) and catalase were not affected by WPS. By contrast, WPS aggravated in vivo thrombosis by shortening the thrombotic occlusion time in pial arterioles and venules. The number of circulating platelets was reduced by WPS suggesting the occurrence of platelet aggregation in vivo. Elevated concentrations of fibrinogen and plasminogen activator inhibitor-1 were seen after the exposure to WPS. Blood samples taken from mice exposed to WPS and exposed to adenosine diphosphate showed more platelet aggregation. The heart concentrations of IL-6 and TNFα were augmented by WPS. Likewise, heart levels of LPO, reactive oxygen species and the antioxidants catalase and GSH were increased by WPS. However, the systolic blood pressure and heart rate were not affected by WPS. Conclusion: It can be concluded that short-term exposure to WPS exerts procoagulatory effects and induce cardiac inflammation and oxidative stress. At the time point investigated, there was no evidence for blood inflammation or oxidative stress.

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Section: Discussionmentioning

confidence: 99%

“…The discrepancy between the latter finding and the current one can be related to the exposure duration, and suggests that the endothelial activation develops over longer period of exposure to WPS. A recent study found no effect of acute exposure of WPS on endothelial function in humans [21]. …”

Section: Discussionmentioning

confidence: 99%

Short-Term Nose-Only Water-Pipe (Shisha) Smoking Exposure Accelerates Coagulation and Causes Cardiac Inflammation and Oxidative Stress in Mice

Yuvaraju

Beegam

Ali

2015

Cell Physiol Biochem

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“…WTS has also been shown to cause acute increases in respiratory rate [99–101], decreased forced expiratory flow [99,100], and decreased peak expiratory flow rate [99,102]. …”

Section: Health Effects Of Waterpipe Smokingmentioning

confidence: 99%

Waterpipe tobacco-smoking: a new smoking epidemic among the young?

2015

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Waterpipe (hookah, narghile) tobacco smoking (WTS) is becoming prevalent worldwide and is one of the most popular forms of tobacco use among youth. WTS prevalence has increased dramatically among youth in the United States within the past decade. Misperceived as less harmful than cigarette smoking, WTS is associated with many of the same chronic health effects such as lung cancer, chronic obstructive pulmonary disease, cardiovascular disease, bronchitis, and asthma. Much of this risk is due to the fact that a single WTS session exposes users to large volumes of smoke that contain toxic chemicals such as carbon monoxide, cancer-causing polycyclic aromatic hydrocarbons, and volatile aldehydes. Unlike cigarette smoking, WTS poses unique risks of acute negative health outcomes including carbon monoxide poisoning and the spread of communicable diseases such as herpes and tuberculosis. Because waterpipe tobacco smoke contains the addictive chemical nicotine, youth who smoke tobacco from a waterpipe may be at risk for dependence. As a result, many youth may initiate WTS and continue to use despite negative health effects. Considering many of the potential negative health effects associated with WTS affect the pulmonary system, pulmonologists and primary care providers may treat patients who are waterpipe tobacco smokers and should be aware of the risk associated with WTS. The purpose of this review is to describe a waterpipe, the prevalence and correlates of WTS, the toxicants found in waterpipe tobacco smoke, the health effects of WTS, and implications for pulmonologists and other clinicians.

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“…Therefore, diseases usually associated with cigarette smoking can also be seen with water pipe smoking, including chronic obstructive pulmonary disease, cardiovascular diseases and cancer …”

Section: Water Pipe Smoking Is Not Less Harmful Than Cigarette Smokingmentioning

confidence: 99%

Water pipe smoking and dermatologic consequences

Wollina

2015

Acad Dermatol Venereol

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Water pipe smoking is a recently growing addiction worldwide. It has become popular in Africa and the Western World and enfaces a renaissance in Middle East and Asia. The smoking technique leads to a different exposure to potential hazardous compounds compared to cigarette or classical pipe smoking. The common assumption that water pipe smoking is less dangerous to health is not substantiated by scientific data. Non-tobacco-based preparations reduce the exposure to nicotine but may contain equal or even higher concentrations of other toxic compounds. The medical literature on adverse effect of water pipe smoking on skin and oral mucosa is reviewed but future research is a demand.

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Laboratory and Clinical Acute Effects of Active and Passive Indoor Group Water-Pipe (Narghile) Smoking

Cited by 60 publications

References 37 publications

Short-Term Nose-Only Water-Pipe (Shisha) Smoking Exposure Accelerates Coagulation and Causes Cardiac Inflammation and Oxidative Stress in Mice

Short-Term Nose-Only Water-Pipe (Shisha) Smoking Exposure Accelerates Coagulation and Causes Cardiac Inflammation and Oxidative Stress in Mice

Waterpipe tobacco-smoking: a new smoking epidemic among the young?

Water pipe smoking and dermatologic consequences

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