Laboratory and clinical studies on the mechanism of action of timolol

Neufeld, Arthur H.; Bartels, S P; Liu, John H.K.

doi:10.1016/0039-6257(83)90152-2

Cited by 44 publications

(12 citation statements)

References 23 publications

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“…This suggests that: (a) concentrations of betaxolol in the eye may be sufficient to block ciliary ~2-receptors (Lesar 1987) and/or (b) ocular ~2-receptors differ from those in other tissues (Lesar 1987;Lotti et al 1984;Neufeld et al 1983). It was not the intention to imply that betaxolol acts solely via specific blockade of ~2-receptors in the management of glaucoma.…”

Section: Discussionmentioning

confidence: 96%

Should Older Patients with Acute Myocardial Infarction Receive Thrombolytic Therapy?

1992

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Section: Discussionmentioning

confidence: 96%

Should Older Patients with Acute Myocardial Infarction Receive Thrombolytic Therapy?

1992

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“…However, reviews (1,2,3) and recent publications (4,5,6) indicate that the actual mechanism of these agents for reducing IOP has not yet been described. In 1991, Whikehart et al (7) reported the inhibition of plasma membrane Na,K-ATPase (E.C.…”

Section: Introductionmentioning

confidence: 94%

The Inhibition of Na, K-ATPase, and Mg-ATPase by Timolol Maleate in Cultured Non-Pigmented Epithelial Cells of the Ciliary Body

Whikehart¹,

Montgomery²,

Sorna³

1992

Journal of Ocular Pharmacology and Therapeutics

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Bovine, non-pigmented, ciliary body epithelial cells were isolated and grown in culture to determine whether timolol maléate might affect the activity of their plasma membrane ATPases. The possible effects were tested in drug concentrations in a range of 5 x 1019 to 5 x 10'5 M over an incubation period of 30 min at 37°. Assays of specific activity showed that the drug significantly (p < .001 for most concentrations) inhibited both Na,K-ATPase and Mg-ATPase. However, the inhibition was partially reversed in concentrations greater than 106 M for Na,K-ATPase and 105 M for Mg-ATPase. The latter enzyme also indicated a second partial reversal in activity at concentrations between 10~12 and 10"9 M. These reversals in activity suggest that more than one binding site is involved in the inhibition of both enzymes. Since Na,K-ATPase in non-pigmented, ciliary body cells is responsible for the generation of aqueous fluid and the intraocular pressure (IOP), this inhibition demonstrates a possible mechanism for the pharmacological action of timolol maléate in lowering IOP.

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“…Il en résulte une baisse de la formation d'AMP-cyclique nécessaire au transport ionique par les cellules de l'épithélium ciliaire non pigmenté, avec une diminution de la sécrétion active d'HA (Bartels et al 1980). Les ␤ bloquants réduisent également la perfusion des capillaires des procès ciliaires avec une diminution de l'ultrafiltration de l'HA (Zimmermann et al 1977 ;Neufeld et al, 1983). Depuis 1978, ces molécules ont constitué une avancée majeure dans le traitement du glaucome primaire à angle ouvert chez l'homme.…”

Section: Sympatholytiques ␤ (␤ Bloquants)unclassified

Glaucomes des carnivores domestiques : revue actualisée du traitement médical et intérêt des prostaglandines

Jegou¹

2007

bavf

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Depuis le 19e siècle et l’introduction de la pilocarpine, des médicaments appartenant à plusieurs classes thérapeutiques ont été utilisés dans le traitement médical des glaucomes. Ce furent successivement les cholinergiques, les agonistes adrénergiques, les médicaments osmotiques, les inhibiteurs de l’anhydrase carbonique, les βbloquants adrénergiques, les agonistes α2 adrénergiques et récemment les analogues des prostaglandines. Caractérisées par un mode d’action original et inédit sur la voie annexe uvéosclérale d’élimination de l’humeur aqueuse, les prostaglandines présentent un progrès notable dans le traitement médical du glaucome primaire chez le chien.

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Laboratory and clinical studies on the mechanism of action of timolol

Cited by 44 publications

References 23 publications

Should Older Patients with Acute Myocardial Infarction Receive Thrombolytic Therapy?

Should Older Patients with Acute Myocardial Infarction Receive Thrombolytic Therapy?

The Inhibition of Na, K-ATPase, and Mg-ATPase by Timolol Maleate in Cultured Non-Pigmented Epithelial Cells of the Ciliary Body

Glaucomes des carnivores domestiques : revue actualisée du traitement médical et intérêt des prostaglandines

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