Laboratory and Field Evaluation of Biodegradable Polyesters for Sustained Release of Isometamidium and Ethidium

Abstract

Key words: review -isometamidium -ethidium -sustained release -prophylaxis -trypanosomiasis -cattleIn order to extend the prophylactic activity of isometamidium (ISMM) and ethidium (homidium bromide) and to decrease their toxic effects at the injection site, several alternative delivery systems have been developed for the treatment of trypanosomiasis of livestock. Peregrine (1994) did review the use of liposomes, carrier erythrocytes, suraminates and dextran complexes. Generally these new formulations were evaluated in laboratory animals and the few experiments in cattle usually gave unsatisfactory results. The use of polymers was also briefly mentioned by Peregrine (1994), but at that time no data were yet available about their application in cattle. The purpose of this minireview is to present and discuss the results obtained during several laboratory and field trials in cattle using sustained release devices containing a mixture of different polyesters and ISMM or ethidium.

The animal trypanosomiases and their chemotherapy: a review

“…Besides correct dosage administration, various other options to extend the life of current trypanocides exist. Different approaches (such as delivery systems including complexing to polymeric substances promoting slow release or alternative formulations) have been considered in order to improve therapeutic efficacy (Peregrine, 1994; Geerts et al 1999; Kroubi et al 2011; Unciti-Broceta et al 2015). These could allow the use of lower quantities of trypanocide in a more effective way and, consequently, pose a decreased risk of toxicity and possibly decreased resistance development.…”