Laboratory assays and duplex scanning outcomes after symptomatic deep vein thrombosis: Preliminary results

Arcelus, Juan I.; Caprini, Joseph A.; Hoffman, Kevin N.; Fink, Nicole; Size, Gail P.; Fareed, J.; Hoppensteadt, Debra

doi:10.1016/s0741-5214(96)80041-3

Cited by 26 publications

(17 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover,with duplexscanning it is possible to measureboth the extent of thrombus in different veins (thrombosis score) and reflux as aresultofvalvular insufficiency. In twos tudiest he rate of complete resolution of thrombus after six to nine months was57% (10,11).…”

Section: Introductionmentioning

confidence: 91%

The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study

Roumen-Klappe¹,

Heijer²,

Janssen³

et al. 2005

Thromb Haemost

113

100

View full text Add to dashboard Cite

The ability to predict severity of the post-thrombotic syndrome (PTS) early after acute deep-vein thrombosis (DVT) is limited. The aim of our study was to examine the incidence of PTS prospectively and to evaluate the predictive value of non-invasive venous examinations shortly after DVT for the development of PTS. In 93 patients with DVT thrombosis score (TS), reflux, venous outflow resistance (VOR) and calf muscle pump dysfunction (CMP) were examined prospectively. After one, two and six years patients were evaluated for PTS using the clinical scale of the CEAP-classification (PTS present > or = 3 on a scale from 0 to 6). Area under the curves (AUC) were used to evaluate the predictive value of the non-invasive examinations at one and three months after diagnosis of DVT for future PTS. The cumulative incidence of PTS increased from 49% (32/65) after one year to 55% (36/65) and 56% (27/48) after two and six years, whereas the incidence of patients with PTS class 4 progressed from 20% after two years to 33% after six years. The prognostic value to predict PTS was highest for the combination of TS, VOR and reflux measured three months after diagnosis and showed an AUC of 0.77 (0.65-0.90) for PTS after one year. In conclusion, the incidence of PTS after DVT did not increase significantly after one year, whereas during longer follow-up the severity of PTS rose in patients with PTS. Moreover, measurement of TS, VOR and reflux three months after DVT could predict, with reasonable accuracy, the risk of PTS after one year of follow-up.

show abstract

Section: Introductionmentioning

confidence: 91%

The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study

Roumen-Klappe¹,

Heijer²,

Janssen³

et al. 2005

Thromb Haemost

113

100

View full text Add to dashboard Cite

show abstract

“…Duplicates from these 2 searches were identified and discarded, leaving 4059 unique articles. Screening and study selection as described above resulted in the identification of 20 articles 20–39 meeting the inclusion criteria (Figure 1). Two articles 29,32 reported data found in other included reports 31,34 and were not included in the final analysis.…”

Section: Resultsmentioning

confidence: 99%

Thrombin Generation Biomarkers Decline With Parenteral Anticoagulation—An Overlooked Means of Anticoagulation Monitoring?

McFarland

Lind

2018

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Anticoagulation therapy is administered to patients to prevent or stop thrombin generation in vivo. Although plasma tests of in vivo thrombin generation have been available for more than 2 decades, they are not routinely used in clinical trials or practice to monitor anticoagulation therapy. We observed a fall in one such marker, the D-dimer antigen, in patients receiving anticoagulation therapy. We therefore conducted a systematic review of the medical literature to document the change in serum biomarkers of thrombin generation following the initiation of anticoagulation therapy. Using a defined search strategy, we screened PubMed and Embase citations and identified full-length articles published in English. Eighteen articles containing serial changes in 1 of 3 markers of thrombin generation (D-dimer antigen, thrombin-antithrombin complexes, and prothrombin fragment 1þ2 antigen levels) in the 14 days following the initiation of anticoagulation were identified. Even though the assays used varied considerably, each of the 3 markers of thrombin generation declined in the initial period of anticoagulation therapy, with changes evident as early as 1 day after beginning therapy. These observations provide a rationale for further exploration of these markers as measures of the adequacy of anticoagulation using classic as well as novel anticoagulants. Particular patient groups that would benefit from additional means of monitoring anticoagulation therapy are discussed.

show abstract

“…37 The incidence of primary incompetence versus postthrombotic damage as a cause of chronic venous insufficiency is not clearly defined, but has been estimated to be approximately 80% post-thrombotic vs 20% primary valvular incompetence. Although the venous lumen is most often recanalized after an episode of deep venous thrombosis, [38][39][40] lysis is rarely complete. Residual thrombus is replaced by fibrous tissue that may cause complete obstruction or cribiform synechiae formed by endothelialized strands of residual thrombus.…”

Section: Pathophysiology Of Venous Reflux and Obstructionmentioning

confidence: 99%

The hemodynamics and diagnosis of venous disease

Meissner

Moneta

Burnand

et al. 2007

Journal of Vascular Surgery

318

233

View full text Add to dashboard Cite

The venous system is, in many respects, more complex than the arterial system and a thorough understanding of venous anatomy, pathophysiology, and available diagnostic tests is required in the management of acute and chronic venous disorders. The venous system develops through several stages, which may be associated with a number of development anomalies. A thorough knowledge of lower extremity venous anatomy, anatomic variants, and the recently updated nomenclature is required of all venous practitioners. Effective venous return from the lower extremities requires the interaction of the heart, a pressure gradient, the peripheral muscle pumps of the leg, and competent venous valves. In the absence of pathology, this system functions to reduce venous pressure from approximately 100 mm Hg to a mean of 22 mm Hg within a few steps. The severe manifestations of chronic venous insufficiency result from ambulatory venous hypertension, or a failure to reduce venous pressure with exercise. Although the precise mechanism remains unclear, venous hypertension is thought to induce the associated skin changes through a number of inflammatory mechanisms. Several diagnostic tests are available for the evaluation of acute and chronic venous disease. Although venous duplex ultrasonography has become the standard for detection of acute deep venous thrombosis, adjuvant modalities such as contrast, computed tomographic, and magnetic resonance venography have an increasing role. Duplex ultrasonography is also the most useful test for detecting and localizing chronic venous obstruction and valvular incompetence. However, it provides relatively little quantitative hemodynamic information and is often combined with measurements of hemodynamic severity determined by a number of plethysmographic methods. Finally, critical assessment of venous treatment modalities requires an understanding of the objective clinical outcome and quality of life instruments available.

show abstract

Laboratory assays and duplex scanning outcomes after symptomatic deep vein thrombosis: Preliminary results

Cited by 26 publications

References 18 publications

The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study

The post-thrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study

Thrombin Generation Biomarkers Decline With Parenteral Anticoagulation—An Overlooked Means of Anticoagulation Monitoring?

The hemodynamics and diagnosis of venous disease

Contact Info

Product

Resources

About