Laboratory Assessment of Anemia

Kundrapu, Sirisha; Noguez, Jaime H.

doi:10.1016/bs.acc.2017.10.006

Cited by 26 publications

(20 citation statements)

References 38 publications

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“…Computation of PIT is described in Equation (1). Hemoglobin-, hematocrit-, red blood cell count-and mean corpuscular volume adjusted versions of PIT were also determined in order to adjust to the various forms of anemia [74] (Equations (2)- (5)…”

Section: Personalized Indicator Thrombocytosismentioning

confidence: 99%

Personalized Indicator Thrombocytosis Shows Connection to Staging and Indicates Shorter Survival in Colorectal Cancer Patients with or without Type 2 Diabetes

Herold

Lohinszky

et al. 2020

Cancers

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Background: Pre- and postoperative thrombocytosis was reported to have significant effect on patient survival. However, the definition of thrombocytosis throughout the literature is not unified. Methods: A retrospective longitudinal observational study has been conducted with the inclusion of 150 colorectal cancer (CRC) patients and 100 control subjects. A new measure of platelet changes at an individual level, named personalized indicator thrombocytosis (PIT) was defined, including 4 anemia adjusted variants. Results: In concordance with the literature, PIT values of control subjects showed a slow decrease in platelet counts, while PIT values of CRC patients were significantly higher (p < 0.0001). More advanced staging (p < 0.0001) and both local (p ≤ 0.0094) and distant (p ≤ 0.0440) metastasis are associated with higher PIT values. Higher PIT values suggested shorter survival times (p < 0.0001). Compared to conventional, a PIT-based definition resulted in approximately 3-times more patients with thrombocytosis. 28% and 77% of the deceased patients had conventional- and PIT-based thrombocytosis, respectively. Conclusions: Compared to conventional thrombocytosis, as an individual metric, PIT values may indicate the condition of patients more precisely. Possible future applications of PIT may include its usage in therapy decision and early cancer detection; therefore, further investigations are recommended.

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Section: Personalized Indicator Thrombocytosismentioning

confidence: 99%

Personalized Indicator Thrombocytosis Shows Connection to Staging and Indicates Shorter Survival in Colorectal Cancer Patients with or without Type 2 Diabetes

Herold

Lohinszky

et al. 2020

Cancers

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“…Iron deficiency and anaemia in young pigs at weaning has been seen in recent studies when a single dose of iron was given within 48 h from birth 38 , 39 . It is also possible that the lifespan of the reticulocytes increased in this phase, as in case of more intense release from the bone marrow 40 .…”

Section: Discussionmentioning

confidence: 99%

Weaning differentially affects the maturation of piglet peripheral blood and jejunal Peyer’s patches

Correa

Luise

Bosi

et al. 2022

Sci Rep

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The study aimed to assess how the post-weaning condition changes piglet peripheral blood (PB) and jejunal Peyer’s patches (JPPs) as compared to the suckling period, and how these changes are associated with intestinal microbiota evolution. Sixteen pigs were slaughtered and sampled for PB, JPPs and jejunal content (JC) at weaning (26 days) or at 12 days fed on a pre-starter diet. The PB and JPP transcriptomes were analysed using mRNA-seq. The Gene Set Enrichment Analysis was used to demonstrate enriched gene clusters, depending on sampling time. Jejunal microbiota was profiled using 16S rRNA gene sequencing. Post-weaning JPPs were enriched for processes related to the activation of IFN-γ and major histocompatibility complex (MHC) class I antigen processing which clustered with the reduced abundance of the Weisella genus and Faecalibacterium prausnitzii in JC. The post-weaning microbiome differed from that seen in just-weaned pigs. For just-weaned PB, the enrichment of genes related to hemoglobin and the iron metabolism indicated the greater presence of reticulocytes and immature erythrocytes. The JPP genes involved in the I MHC and IFN-γ activations were markers of the post-weaning phase. Several genes attributable to reticulocyte and erythrocyte maturation could be interesting for testing the iron nutrition of piglets.

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“…According to the morphologic approach, anemias are categorized based on the size of RBC measured by mean corpuscular volume (MCV) into microcytic anemia (MCV <80 fL), normocytic anemia (MCV 80-100 fL), and macrocytic anemia (MCV >100 fL) (shown in Fig. 2) [13].…”

Section: Classification and Diagnosis Of Anemiamentioning

confidence: 99%

“…Using a kinetic approach, anemias are classified based on the responsible pathophysiological mechanism including decreased RBC production, increased RBC destruction, and blood loss (shown in Fig. 1) [13]. The reticulocyte count is used to estimate the degree of effective erythropoiesis with corrected reticulocyte count <2% in hypoproliferative anemia and >2% in hyperproliferative anemia [2].…”

Section: Classification and Diagnosis Of Anemiamentioning

confidence: 99%

“…The manifestation of symptoms in patients depends on the etiology of anemia, severity of onset, and presence of other comorbidities. According to conducted investigations, the majority of patients become symptomatic when Hb values drop below 7.0 g/dL [2, 13, 14]. Obtaining a good history from a patient with anemia is important for further diagnostic algorithm with questions addressing prior blood loss, duration of anemia, associated features and comorbidities, and use of proton pump inhibitors, aspirin, and nonsteroidal anti-inflammatory drugs [15].…”

Section: Clinical Presentation and Features Of Anemiamentioning

confidence: 99%

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Anemia as a Problem: GP Approach

Milovanović

Dragašević

A³

et al. 2021

Dig Dis

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Background: Anemia is a presentation of an underlying disease or deficiency. As stated by the WHO, anemia is defined as hemoglobin (Hb) levels <12.0 g/dL in women and <13.0 g/dL in men. This review of clinical practice aimed to determine the diagnostic approach to anemia in primary care patients. Summary: Nutritional deficiencies, medications, chronic inflammatory conditions, malignancy, renal dysfunction, and bone marrow and inherent disorders contribute to anemia development. Anemia is classified and diagnosed by the values of hematological parameters, underlying pathological mechanism, and patient history. The diagnostic approach of anemia in primary care settings is focused on history, physical examination, laboratory findings including complete blood cell count, reticulocyte count, and peripheral smear examination, fecal occult blood test, and ultrasound findings. Key Messages: Anemia is the most common hematological disorder that represents a major health burden worldwide. Hb levels alter with gender, ethnicity, and physiological status. Anemia is often multifactorial. The evaluation of a patient with anemia in primary care includes clinical history, physical examination, and laboratory findings with fecal occult blood test and abdominal ultrasound. The wide variations in general practice in European countries are based on different health care systems but also knowledge of GPs that reflect educational and research policy.

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Laboratory Assessment of Anemia

Cited by 26 publications

References 38 publications

Personalized Indicator Thrombocytosis Shows Connection to Staging and Indicates Shorter Survival in Colorectal Cancer Patients with or without Type 2 Diabetes

Personalized Indicator Thrombocytosis Shows Connection to Staging and Indicates Shorter Survival in Colorectal Cancer Patients with or without Type 2 Diabetes

Weaning differentially affects the maturation of piglet peripheral blood and jejunal Peyer’s patches

Anemia as a Problem: GP Approach

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